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Tns1 tensin 1 [ Mus musculus (house mouse) ]

Gene ID: 21961, updated on 8-May-2016
Official Symbol
Tns1provided by MGI
Official Full Name
tensin 1provided by MGI
Primary source
MGI:MGI:104552
See related
Ensembl:ENSMUSG00000055322 Vega:OTTMUSG00000047279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tns; AI648117; 1110018I21Rik; 1200014E20Rik; E030018G17Rik; E030037J05Rik
Location:
1 C3; 1 38.17 cM
Exon count:
54
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (73910231..74124535, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (73956805..74171021, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6030407O03 gene Neighboring gene predicted gene 29183 Neighboring gene microRNA 6351 Neighboring gene predicted gene, 39664 Neighboring gene predicted gene, 31637 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene chemokine (C-X-C motif) receptor 2

  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding TAS
Traceable Author Statement
more info
PubMed 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell-substrate junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell-substrate junction IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289895.1NP_001276824.1  tensin 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC116419, AI315947, AK004758, AK053112, AK137923, AW611438, BC052740, CF171717, CF540284, CJ125619, CJ241954, CN697610
    Consensus CDS
    CCDS48288.2
    UniProtKB/TrEMBL
    A0A087WQS0, Q7TSV1, Q8C6V6, Q9DBT6
    Related
    ENSMUSP00000140317, OTTMUSP00000067201, ENSMUST00000191104, OTTMUST00000122614
    Conserved Domains (5) summary
    cd09927
    Location:15911706
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:248363
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:350476
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:75108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:17281861
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  2. NM_027884.3NP_082160.3  tensin 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC116419, AC117757
    Consensus CDS
    CCDS78614.1
    UniProtKB/TrEMBL
    E9Q0S6
    Related
    ENSMUSP00000127715, ENSMUST00000169786
    Conserved Domains (5) summary
    cd09927
    Location:16121727
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:248363
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:350476
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:75108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:17491882
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    73910231..74124535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495871.2XP_006495934.1  

    Conserved Domains (5) summary
    cd09927
    Location:16421757
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:248363
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:350476
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:75108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:17791912
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  2. XM_006495867.2XP_006495930.2  

    Conserved Domains (5) summary
    cd09927
    Location:16461761
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:252367
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:354480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:17831916
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  3. XM_006495878.2XP_006495941.1  

    See identical proteins and their annotated locations for XP_006495941.1

    Conserved Domains (4) summary
    cd09927
    Location:14921607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:98213
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:200326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16291762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  4. XM_006495870.2XP_006495933.1  

    Conserved Domains (5) summary
    cd09927
    Location:16491764
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:306421
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:408534
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:133166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:17861919
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  5. XM_006495868.2XP_006495931.1  

    Conserved Domains (5) summary
    cd09927
    Location:16571772
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:306421
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:408534
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:133166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:17941927
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  6. XM_006495876.2XP_006495939.1  

    Conserved Domains (5) summary
    cd09927
    Location:15291644
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:306421
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:408534
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:133166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:16661799
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  7. XM_006495869.2XP_006495932.1  

    Conserved Domains (5) summary
    cd09927
    Location:16511766
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:306421
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:408534
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:133166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:17881921
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  8. XM_006495866.2XP_006495929.1  

    Conserved Domains (6) summary
    pfam03157
    Location:6641273
    Glutenin_hmw; High molecular weight glutenin subunit
    cd09927
    Location:16791794
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:306421
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:408534
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:133166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:18161949
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  9. XM_006495864.2XP_006495927.1  

    Conserved Domains (6) summary
    pfam03157
    Location:6641217
    Glutenin_hmw; High molecular weight glutenin subunit
    cd09927
    Location:16921807
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:306421
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:408534
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:133166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:18291962
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  10. XM_006495865.2XP_006495928.1  

    Conserved Domains (6) summary
    pfam03157
    Location:6641217
    Glutenin_hmw; High molecular weight glutenin subunit
    cd09927
    Location:16871802
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:306421
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:408534
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:133166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:18241957
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  11. XM_006495863.2XP_006495926.1  

    Conserved Domains (5) summary
    cd09927
    Location:17001815
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:306421
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:408534
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:133166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:18371970
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  12. XM_006495872.1XP_006495935.1  

    Conserved Domains (5) summary
    cd09927
    Location:16011716
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:207322
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:309435
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:3467
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:17381871
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  13. XM_006495875.2XP_006495938.1  

    Conserved Domains (4) summary
    cd09927
    Location:15531668
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:159274
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:261387
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16901823
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  14. XM_011238476.1XP_011236778.1  

    See identical proteins and their annotated locations for XP_011236778.1

    Conserved Domains (4) summary
    cd09927
    Location:14921607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:98213
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:200326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16291762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  15. XM_006495874.2XP_006495937.1  

    Conserved Domains (4) summary
    cd09927
    Location:15681683
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:174289
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:276402
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:17051838
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  16. XM_006495877.2XP_006495940.1  

    See identical proteins and their annotated locations for XP_006495940.1

    Conserved Domains (4) summary
    cd09927
    Location:14921607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:98213
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:200326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16291762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  17. XM_006495880.2XP_006495943.1  

    See identical proteins and their annotated locations for XP_006495943.1

    Conserved Domains (4) summary
    cd09927
    Location:14921607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:98213
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:200326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16291762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  18. XM_006495873.2XP_006495936.2  

    Conserved Domains (4) summary
    cd09927
    Location:15521667
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:158273
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:260386
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16891822
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  19. XM_011238477.1XP_011236779.1  

    See identical proteins and their annotated locations for XP_011236779.1

    Conserved Domains (4) summary
    cd09927
    Location:14921607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:98213
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:200326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16291762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  20. XM_006495879.1XP_006495942.1  

    See identical proteins and their annotated locations for XP_006495942.1

    Conserved Domains (4) summary
    cd09927
    Location:14921607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:98213
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:200326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16291762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  21. XM_006495881.2XP_006495944.1  

    See identical proteins and their annotated locations for XP_006495944.1

    Conserved Domains (4) summary
    cd09927
    Location:14921607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:98213
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:200326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16291762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  22. XM_006495882.2XP_006495945.1  

    See identical proteins and their annotated locations for XP_006495945.1

    Related
    ENSMUSP00000140094, OTTMUSP00000067257, ENSMUST00000185702, OTTMUST00000122841
    Conserved Domains (4) summary
    cd09927
    Location:14921607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:98213
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:200326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd01213
    Location:16291762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  23. XM_006495883.1XP_006495946.1  

    Conserved Domains (2) summary
    cd09927
    Location:10131128
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    cd01213
    Location:11501283
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
  24. XM_006495884.2XP_006495947.1  

    Conserved Domains (3) summary
    smart00404
    Location:306421
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:408534
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:133166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    74471979..74685730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177169.2: Suppressed sequence

    Description
    NM_177169.2: This RefSeq was permanently suppressed because it contains the wrong CDS.