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Tnnt2 troponin T2, cardiac [ Mus musculus (house mouse) ]

Gene ID: 21956, updated on 28-May-2016
Official Symbol
Tnnt2provided by MGI
Official Full Name
troponin T2, cardiacprovided by MGI
Primary source
MGI:MGI:104597
See related
Ensembl:ENSMUSG00000026414 Vega:OTTMUSG00000049830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tnt; cTnT
Orthologs
Location:
1 E4; 1 59.32 cM
Exon count:
19
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (135836316..135852268)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (137732963..137748838)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene troponin I, skeletal, slow 1 Neighboring gene ladinin Neighboring gene plakophilin 1 Neighboring gene immunoglobulin-like and fibronectin type III domain containing 1 Neighboring gene transmembrane protein 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
    Striated Muscle Contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
    Striated Muscle Contraction, organism-specific biosystem
    Striated Muscle Contraction

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ATPase activity ISO
Inferred from Sequence Orthology
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding, bridging ISO
Inferred from Sequence Orthology
more info
 
structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
tropomyosin binding ISO
Inferred from Sequence Orthology
more info
 
troponin C binding ISO
Inferred from Sequence Orthology
more info
 
troponin I binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin crosslink formation ISO
Inferred from Sequence Orthology
more info
 
atrial cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
muscle contraction ISO
Inferred from Sequence Orthology
more info
 
muscle filament sliding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of muscle filament sliding speed ISO
Inferred from Sequence Orthology
more info
 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
myofibril IDA
Inferred from Direct Assay
more info
PubMed 
myofibril ISO
Inferred from Sequence Orthology
more info
 
sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
striated muscle thin filament ISO
Inferred from Sequence Orthology
more info
 
troponin complex IDA
Inferred from Direct Assay
more info
PubMed 
troponin complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
troponin T, cardiac muscle
Names
cardiac TnT
cardiac muscle troponin T
tnTc

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130174.2NP_001123646.1  troponin T, cardiac muscle isoform a

    See identical proteins and their annotated locations for NP_001123646.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AC162441, AK146945
    Consensus CDS
    CCDS48375.1
    UniProtKB/TrEMBL
    Q6P3Z7
    Related
    ENSMUSP00000140941, OTTMUSP00000068588, ENSMUST00000188028, OTTMUST00000126900
    Conserved Domains (1) summary
    pfam00992
    Location:110237
    Troponin; Troponin
  2. NM_001130175.2NP_001123647.4  troponin T, cardiac muscle isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (g) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC162441
    Conserved Domains (1) summary
    pfam00992
    Location:138265
    Troponin; Troponin
  3. NM_001130176.1NP_001123648.1  troponin T, cardiac muscle isoform b

    See identical proteins and their annotated locations for NP_001123648.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate exon in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region, and includes an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC162441, BC063753, L47553
    Consensus CDS
    CCDS48377.1
    UniProtKB/Swiss-Prot
    P50752
    UniProtKB/TrEMBL
    Q54AB6, Q6P3Z7
    Related
    ENSMUSP00000107717, OTTMUSP00000068593, ENSMUST00000112087, OTTMUST00000126907
    Conserved Domains (1) summary
    pfam00992
    Location:106236
    Troponin; Troponin
  4. NM_001130177.2NP_001123649.1  troponin T, cardiac muscle isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC162441, AK163786, AK168393
    UniProtKB/TrEMBL
    Q3TH80, Q3TQ90
    Conserved Domains (1) summary
    pfam00992
    Location:106233
    Troponin; Troponin
  5. NM_001130178.2NP_001123650.1  troponin T, cardiac muscle isoform d

    See identical proteins and their annotated locations for NP_001123650.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, and includes an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC162441, AK169061, BQ554639
    Consensus CDS
    CCDS48376.1
    UniProtKB/Swiss-Prot
    P50752
    Related
    ENSMUSP00000139669, OTTMUSP00000068590, ENSMUST00000189732, OTTMUST00000126904
    Conserved Domains (1) summary
    pfam00992
    Location:100230
    Troponin; Troponin
  6. NM_001130179.2NP_001123651.4  troponin T, cardiac muscle isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1. The encoded isoform (h) is longer than isoform a.
    Source sequence(s)
    AC162441, L47599
    UniProtKB/Swiss-Prot
    P50752
    Conserved Domains (1) summary
    pfam00992
    Location:128258
    Troponin; Troponin
  7. NM_001130180.2NP_001123652.1  troponin T, cardiac muscle isoform e

    See identical proteins and their annotated locations for NP_001123652.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate in-frame exons in the 5' coding region, and includes an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC162441, L47552
    Consensus CDS
    CCDS48378.1
    UniProtKB/Swiss-Prot
    P50752
    Related
    ENSMUSP00000139919, OTTMUSP00000068591, ENSMUST00000189355, OTTMUST00000126905
    Conserved Domains (1) summary
    pfam00992
    Location:96226
    Troponin; Troponin
  8. NM_001130181.2NP_001123653.4  troponin T, cardiac muscle isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has multiple differences in the coding region, compared to variant 1. The encoded isoform (i) is longer than isoform 1.
    Source sequence(s)
    AC162441, L47551
    UniProtKB/Swiss-Prot
    P50752
    Conserved Domains (1) summary
    pfam00992
    Location:124254
    Troponin; Troponin
  9. NM_011619.3NP_035749.1  troponin T, cardiac muscle isoform f

    See identical proteins and their annotated locations for NP_035749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. The resulting isoform (f) is shorter than isoform a.
    Source sequence(s)
    AC162441, L47600
    UniProtKB/Swiss-Prot
    P50752
    Conserved Domains (1) summary
    pfam00992
    Location:96223
    Troponin; Troponin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    135836316..135852268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529383.2XP_006529446.2  

    Conserved Domains (1) summary
    pfam00992
    Location:138268
    Troponin; Troponin
  2. XM_006529384.2XP_006529447.2  

    Conserved Domains (1) summary
    pfam00992
    Location:137267
    Troponin; Troponin
  3. XM_006529386.2XP_006529449.2  

    Conserved Domains (1) summary
    pfam00992
    Location:137264
    Troponin; Troponin
  4. XM_006529387.2XP_006529450.2  

    Conserved Domains (1) summary
    pfam00992
    Location:133263
    Troponin; Troponin
  5. XM_006529389.2XP_006529452.2  

    Conserved Domains (1) summary
    pfam00992
    Location:123253
    Troponin; Troponin
  6. XM_006529392.2XP_006529455.1  

    See identical proteins and their annotated locations for XP_006529455.1

    Conserved Domains (1) summary
    pfam00992
    Location:110240
    Troponin; Troponin
  7. XM_006529394.2XP_006529457.1  

    See identical proteins and their annotated locations for XP_006529457.1

    UniProtKB/Swiss-Prot
    P50752
    UniProtKB/TrEMBL
    Q54AB6
    Conserved Domains (1) summary
    pfam00992
    Location:106236
    Troponin; Troponin
  8. XM_006529385.2XP_006529448.2  

    Conserved Domains (1) summary
    pfam00992
    Location:134264
    Troponin; Troponin
  9. XM_006529388.2XP_006529451.2  

    Conserved Domains (1) summary
    pfam00992
    Location:134261
    Troponin; Troponin
  10. XM_006529390.2XP_006529453.2  

    Conserved Domains (1) summary
    pfam00992
    Location:124251
    Troponin; Troponin
  11. XM_006529395.2XP_006529458.1  

    See identical proteins and their annotated locations for XP_006529458.1

    UniProtKB/Swiss-Prot
    P50752
    Conserved Domains (1) summary
    pfam00992
    Location:96226
    Troponin; Troponin
  12. XM_006529391.2XP_006529454.1  

    See identical proteins and their annotated locations for XP_006529454.1

    Conserved Domains (1) summary
    pfam00992
    Location:110240
    Troponin; Troponin
  13. XM_006529393.2XP_006529456.1  

    See identical proteins and their annotated locations for XP_006529456.1

    UniProtKB/Swiss-Prot
    P50752
    UniProtKB/TrEMBL
    Q54AB6
    Conserved Domains (1) summary
    pfam00992
    Location:106236
    Troponin; Troponin

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    138471140..138487075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)