OR5R1 olfactory receptor, family 5, subfamily R, member 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: OR5R1provided by HGNC
Official Full Name: olfactory receptor, family 5, subfamily R, member 1provided by HGNC
Primary source: HGNC:14841
See related: Ensembl:ENSG00000174942; HPRD:15049; Vega:OTTHUMG00000154219
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OR5R1P; OR11-185
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 11q12.1

Sequence :: Chromosome: 11; NC_000011.9 (56184734..56185708, complement)

See OR5R1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Pathways from BioSystems

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GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
Olfactory Signaling Pathway, organism-specific biosystem (from REACTOME)
Olfactory Signaling Pathway, organism-specific biosystemMammalian Olfactory Receptor (OR) genes were discoved in rats by Linda Buck and Richard Axel, who predicted that odorants would be detected by a large family of G protein-coupled receptors (GPCRs) th...
Olfactory transduction, organism-specific biosystem (from KEGG)
Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
Olfactory transduction, conserved biosystem (from KEGG)
Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

General gene information

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Homology

Homologs of the OR5R1 gene: The OR5R1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
G-protein coupled receptor activity	IEA Inferred from Electronic Annotation more info
olfactory receptor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: olfactory receptor 5R1

Names: olfactory receptor 5R1; olfactory receptor OR11-185; olfactory receptor, family 5, subfamily R, member 1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004744.1 → NP_001004744.1 olfactory receptor 5R1

Status: PROVISIONAL

Source sequence(s)

AB065504

Consensus CDS

CCDS31530.1

UniProtKB/Swiss-Prot

Q8NH85

Related

ENSP00000308595, OTTHUMP00000205328, ENST00000312253, OTTHUMT00000334444

Conserved Domains (2) summary

pfam00001
Location:54 – 290
Blast Score: 281

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13853
Location:139 – 283
Blast Score: 404

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

56184734..56185708, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

52521645..52522619, complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

56104843..56105817, complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB065504.1	BAC05752.1
genomic	ABBA01021463.1 (220014..220988)	None
genomic	AMYH01003648.1 (253905..254879)	None
genomic	AP002512.4 (58437..59408)	None
genomic	BK004514.1	DAA04912.1
genomic	CH471076.1	EAW73713.1
genomic	CS248564.1	CAJ56868.1