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Dtymk deoxythymidylate kinase [ Mus musculus (house mouse) ]

Gene ID: 21915, updated on 11-Apr-2024

Summary

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Official Symbol
Dtymkprovided by MGI
Official Full Name
deoxythymidylate kinaseprovided by MGI
Primary source
MGI:MGI:108396
See related
Ensembl:ENSMUSG00000026281 AllianceGenome:MGI:108396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmk; CDC8; TMPK; TYPK; mtmk; D10Ertd203e
Summary
Enables thymidylate kinase activity. Acts upstream of or within cellular response to growth factor stimulus and dTDP biosynthetic process. Predicted to be located in mitochondrial intermembrane space and mitochondrial matrix. Predicted to be active in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; midbrain; and respiratory system. Orthologous to human DTYMK (deoxythymidylate kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 57.9), liver E14 (RPKM 48.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 D; 1 47.34 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93720298..93730246, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93792576..93802068, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene THAP domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_01735 Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95698432-95698719 Neighboring gene STARR-positive B cell enhancer ABC_E4338 Neighboring gene predicted gene, 22089 Neighboring gene inhibitor of growth family, member 5 Neighboring gene STARR-positive B cell enhancer ABC_E7734 Neighboring gene D-2-hydroxyglutarate dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization of the murine thymidylate kinase gene. Liang P, et al. Cell Growth Differ, 1995 Oct. PMID 8845311
  2. Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. Moon S, et al. Cell Death Dis, 2018 Nov 2. PMID 30389914, Free PMC Article
  3. Gene expression profile of aging and its retardation by caloric restriction. Lee CK, et al. Science, 1999 Aug 27. PMID 10464095
  4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables thymidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thymidylate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thymidylate kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dTDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dTDP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dTDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dTTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dTTP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dUDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nucleoside monophosphate phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in thymidine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thymidylate kinase
Names
dTMP kinase
NP_001099137.1
NP_075625.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105667.1 → NP_001099137.1  thymidylate kinase isoform 1

    See identical proteins and their annotated locations for NP_001099137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AI462533, BY098372, C78743, CB182101
    Consensus CDS
    CCDS48329.1
    UniProtKB/Swiss-Prot
    P97930, Q8C2L0, Q8K2S2
    Related
    ENSMUSP00000027503.8, ENSMUST00000027503.14
    Conserved Domains (1) summary
    PLN02924
    Location:5 → 211
    PLN02924; thymidylate kinase

  2. NM_023136.2 → NP_075625.1  thymidylate kinase isoform 2

    See identical proteins and their annotated locations for NP_075625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site and lacks much of the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA014471, BY098372, CF983443
    Consensus CDS
    CCDS35672.1
    UniProtKB/TrEMBL
    Q6GRA7
    Related
    ENSMUSP00000108511.3, ENSMUST00000112890.3
    Conserved Domains (1) summary
    cl17190
    Location:5 → 78
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93720298..93730246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003954565.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97930.2 GenPept UniProtKB/Swiss-Prot:P97930

Gene LinkOut

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