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Dtymk deoxythymidylate kinase [ Mus musculus (house mouse) ]

Gene ID: 21915, updated on 21-May-2016
Official Symbol
Dtymkprovided by MGI
Official Full Name
deoxythymidylate kinaseprovided by MGI
Primary source
MGI:MGI:108396
See related
Ensembl:ENSMUSG00000026281 Vega:OTTMUSG00000022163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmk; CDC8; TMPK; TYPK; mtmk; AU044245; D10Ertd203e
Orthologs
Location:
1 D; 1 47.34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (93792576..93801934, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (95689153..95698511, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene THAP domain containing 4 Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene inhibitor of growth family, member 5 Neighboring gene D-2-hydroxyglutarate dehydrogenase

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside phosphate kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
thymidylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
thymidylate kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
uridylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
dTDP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
dTDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
dTTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
dTTP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
dUDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
thymidylate kinase
Names
dTMP kinase
NP_001099137.1
NP_075625.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105667.1NP_001099137.1  thymidylate kinase isoform 1

    See identical proteins and their annotated locations for NP_001099137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AI462533, BY098372, C78743, CB182101
    Consensus CDS
    CCDS48329.1
    UniProtKB/Swiss-Prot
    P97930
    Related
    ENSMUSP00000027503, OTTMUSP00000024976, ENSMUST00000027503, OTTMUST00000052626
    Conserved Domains (2) summary
    cd01672
    Location:8194
    TMPK; Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step ...
    pfam02223
    Location:11191
    Thymidylate_kin; Thymidylate kinase
  2. NM_023136.2NP_075625.1  thymidylate kinase isoform 2

    See identical proteins and their annotated locations for NP_075625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site and lacks much of the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA014471, BY098372, CF983443
    Consensus CDS
    CCDS35672.1
    UniProtKB/TrEMBL
    Q6GRA7
    Related
    ENSMUSP00000108511, OTTMUSP00000024977, ENSMUST00000112890, OTTMUST00000052627
    Conserved Domains (1) summary
    cl21455
    Location:578
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    93792576..93801934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    96736573..96746015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)