U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spata13 spermatogenesis associated 13 [ Mus musculus (house mouse) ]

Gene ID: 219140, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Spata13provided by MGI
Official Full Name
spermatogenesis associated 13provided by MGI
Primary source
MGI:MGI:104838
See related
Ensembl:ENSMUSG00000021990 AllianceGenome:MGI:104838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
asef2; ESTM11; mFLJ00298
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Predicted to be located in several cellular components, including filopodium; lamellipodium; and ruffle membrane. Is expressed in brain; thymus primordium; and vertebral cartilage condensation. Orthologous to human SPATA13 (spermatogenesis associated 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.9), adrenal adult (RPKM 5.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14 D1; 14 31.77 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (60722617..61002005)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60485168..60764556)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene APC membrane recruitment 2 Neighboring gene peptidylprolyl isomerase A pseudogene 14_696.1 Neighboring gene STARR-positive B cell enhancer ABC_E11785 Neighboring gene VISTA enhancer mm1122 Neighboring gene STARR-positive B cell enhancer ABC_E11571 Neighboring gene predicted gene, 41166 Neighboring gene STARR-seq mESC enhancer starr_36860 Neighboring gene predicted gene, 41165 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61328022-61328292 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61351140-61351293 Neighboring gene STARR-seq mESC enhancer starr_36862 Neighboring gene STARR-positive B cell enhancer mm9_chr14:61357423-61357724 Neighboring gene STARR-seq mESC enhancer starr_36864 Neighboring gene predicted gene, 34997 Neighboring gene C1q and tumor necrosis factor related protein 9 Neighboring gene mitochondrial intermediate peptidase, opposite strand

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity. Bourbia N, et al. Mamm Genome, 2019 Apr. PMID 31020388, Free PMC Article
  2. The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. Kawasaki Y, et al. EMBO Rep, 2009 Dec. PMID 19893577, Free PMC Article
  3. Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. Chaboub LS, et al. J Neurosci, 2016 Nov 23. PMID 27881777, Free PMC Article
  4. Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Yoshizawa M, et al. Gene Expr Patterns, 2003 Jun. PMID 12799088
  5. A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex. Najas S, et al. Development, 2020 Jul 13. PMID 32541003

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spata13 modulates social hierarchy in both male and female mice in addition to affecting voluntary activity in females.
    Title: The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity.
  2. Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. [Asef2, mouse]
    Title: The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ00298

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
spermatogenesis-associated protein 13
Names
APC-stimulated guanine nucleotide exchange factor 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033272.3 → NP_001028444.1  spermatogenesis-associated protein 13 isoform 1

    See identical proteins and their annotated locations for NP_001028444.1

    Status: VALIDATED

    Source sequence(s)
    AC114000, AC151835
    Consensus CDS
    CCDS49516.1
    UniProtKB/TrEMBL
    B9EHV2, E9Q3I3
    Related
    ENSMUSP00000022566.8, ENSMUST00000022566.14
    Conserved Domains (4) summary
    cd11973
    Location:726 → 797
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:836 → 1015
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:200 → 446
    PHA03247; large tegument protein UL36; Provisional
    cd01224
    Location:1020 → 1158
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  2. NM_001310594.2 → NP_001297523.1  spermatogenesis-associated protein 13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114000, AC151835
    Consensus CDS
    CCDS79328.1
    UniProtKB/Swiss-Prot
    Q3TZ09, Q5DU57
    UniProtKB/TrEMBL
    B7ZNJ6, E0CYU0
    Related
    ENSMUSP00000123888.2, ENSMUST00000162945.2
    Conserved Domains (4) summary
    cd11973
    Location:56 → 127
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    cd01224
    Location:350 → 488
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:378 → 477
    PH; PH domain
    pfam00621
    Location:166 → 345
    RhoGEF; RhoGEF domain

  3. NM_001404949.1 → NP_001391878.1  spermatogenesis-associated protein 13 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114000, AC151835, AC164429

  4. NM_001404950.1 → NP_001391879.1  spermatogenesis-associated protein 13 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114000, AC151835

  5. NM_001404951.1 → NP_001391880.1  spermatogenesis-associated protein 13 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114000, AC151835

  6. NM_001404952.1 → NP_001391881.1  spermatogenesis-associated protein 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114000, AC151835

  7. NM_001404953.1 → NP_001391882.1  spermatogenesis-associated protein 13 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC114000, AC151835

  8. NM_001404954.1 → NP_001391883.1  spermatogenesis-associated protein 13 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC114000, AC151835

  9. NM_001404964.1 → NP_001391893.1  spermatogenesis-associated protein 13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114000, AC151835
    UniProtKB/TrEMBL
    E9Q3I3
    Related
    ENSMUSP00000123928.2, ENSMUST00000160973.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    60722617..61002005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247763.1 → XP_030103623.1  spermatogenesis-associated protein 13 isoform X3

    UniProtKB/TrEMBL
    B9EHV2, E9Q3I3
    Conserved Domains (4) summary
    cd11973
    Location:726 → 797
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:836 → 1015
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:200 → 446
    PHA03247; large tegument protein UL36; Provisional
    cd01224
    Location:1020 → 1158
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  2. XM_017315974.3 → XP_017171463.1  spermatogenesis-associated protein 13 isoform X8

    Conserved Domains (1) summary
    PHA03247
    Location:251 → 497
    PHA03247; large tegument protein UL36; Provisional

  3. XM_036158561.1 → XP_036014454.1  spermatogenesis-associated protein 13 isoform X1

    UniProtKB/TrEMBL
    B9EHV2
    Conserved Domains (4) summary
    cd11973
    Location:777 → 848
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:887 → 1066
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:251 → 497
    PHA03247; large tegument protein UL36; Provisional
    cd01224
    Location:1071 → 1209
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  4. XM_036158562.1 → XP_036014455.1  spermatogenesis-associated protein 13 isoform X2

    UniProtKB/TrEMBL
    B9EHV2
    Conserved Domains (4) summary
    cd11973
    Location:767 → 838
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:877 → 1056
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:251 → 500
    PHA03247; large tegument protein UL36; Provisional
    cd01224
    Location:1061 → 1199
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  5. XM_036158565.1 → XP_036014458.1  spermatogenesis-associated protein 13 isoform X5

    UniProtKB/TrEMBL
    B9EHV2
    Conserved Domains (4) summary
    cd11973
    Location:655 → 726
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:765 → 944
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:251 → 603
    PHA03247; large tegument protein UL36; Provisional
    cd01224
    Location:949 → 1087
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  6. XM_011245026.3 → XP_011243328.1  spermatogenesis-associated protein 13 isoform X3

    See identical proteins and their annotated locations for XP_011243328.1

    UniProtKB/TrEMBL
    B9EHV2, E9Q3I3
    Conserved Domains (4) summary
    cd11973
    Location:726 → 797
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:836 → 1015
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:200 → 446
    PHA03247; large tegument protein UL36; Provisional
    cd01224
    Location:1020 → 1158
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  7. XM_030247762.1 → XP_030103622.1  spermatogenesis-associated protein 13 isoform X3

    UniProtKB/TrEMBL
    B9EHV2, E9Q3I3
    Conserved Domains (4) summary
    cd11973
    Location:726 → 797
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:836 → 1015
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:200 → 446
    PHA03247; large tegument protein UL36; Provisional
    cd01224
    Location:1020 → 1158
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  8. XM_030247764.1 → XP_030103624.1  spermatogenesis-associated protein 13 isoform X3

    UniProtKB/TrEMBL
    B9EHV2, E9Q3I3
    Conserved Domains (4) summary
    cd11973
    Location:726 → 797
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:836 → 1015
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:200 → 446
    PHA03247; large tegument protein UL36; Provisional
    cd01224
    Location:1020 → 1158
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  9. XM_006518870.3 → XP_006518933.1  spermatogenesis-associated protein 13 isoform X7

    UniProtKB/Swiss-Prot
    Q3TZ09, Q5DU57
    Conserved Domains (3) summary
    cd11973
    Location:231 → 302
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:341 → 520
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:525 → 663
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DU57.2 GenPept UniProtKB/Swiss-Prot:Q5DU57

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous