FAP fibroblast activation protein, alpha [Homo sapiens (human)] - Gene

Summary

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Official Symbol: FAPprovided by HGNC
Official Full Name: fibroblast activation protein, alphaprovided by HGNC
Primary source: HGNC:3590
See related: Ensembl:ENSG00000078098; HPRD:02674; MIM:600403; Vega:OTTHUMG00000153890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAPA; DPPIV
Summary: The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 2q23

Sequence :: Chromosome: 2; NC_000002.11 (163027200..163100045, complement)

See FAP in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

High intratumoral expression of fibroblast activation protein is associated with colorectal cancer.
Title: High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis.
REVIEW: key modulator of the microenvironment in multiple pathologies
Title: Fibroblast activation protein-α: a key modulator of the microenvironment in multiple pathologies.
Study validates the proteolytic activity of FAP as a target for the activation of a systemically delivered cytotoxic prodrug.
Title: Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug.
FAP is an important regulator of the microenvironment in tumor formation
Title: Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells.
analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha
Title: Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein α.
Higher plasma seprase was associated with better survival in all non-metastatic cancers combined.
Title: Plasma seprase and DPP4 levels as markers of disease and prognosis in cancer.
Strong FAPalpha and TGF-beta1 expressions were detected in myocardial cytoplasm in both acute and recurrent myocardial infarction groups.
Title: [Expression of FAPalpha and TGF-beta1 in sudden deaths due to acute myocardial ischemia].
FAP may play an important role in the occurrence and development of HBV related hepatocellular carcinoma.
Title: [Expression of fibroblast activation protein in HBV related hepatocellular carcinoma].
Studies indicate that the identification of fibroblast activation protein alpha (FAP) as a target selectively expressed on carcinoma-associated fibroblasts led to intensive efforts to exploit this novel cellular target for clinical benefit.
Title: Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy.
Data show that fibroblast activation protein is highly expressed in carcinoma cells and fibroblasts in PDAC tissues, and its expression is associated with desmoplasia and worse prognosis.
Title: Expression of fibroblast activation protein in human pancreatic adenocarcinoma and its clinicopathological significance.

Submit: New GeneRIF Correction See all (46)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
Q12884	P27487	DPP4	HPRD	PubMed
Q12884	Q12884	FAP	HPRD	PubMed
Q12884	Q03405	PLAUR	HPRD	PubMed
BioGRID:108485	BioGRID:115385	HUWE1	BioGRID	PubMed	Co-fractionation
BioGRID:108485	BioGRID:111345	PLAUR	BioGRID	PubMed	FRET
BioGRID:108485	BioGRID:119029	SH3KBP1	BioGRID	PubMed	Co-fractionation
BioGRID:108485	BioGRID:116982	SIRT3	BioGRID	PubMed	Positive Genetic

General gene information

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Markers

SHGC-12594 (e-PCR)
- UniSTS:1065

SHGC-132096 (e-PCR)
- UniSTS:170643

Fap (e-PCR), detects polymorphism
- UniSTS:143070

Genotypes

See FAP SNP Geneview Report
See FAP SNP Genotype Report
See FAP SNP Variation Viewer Report

Homology

Homologs of the FAP gene: The FAP gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
dipeptidyl-peptidase activity	NAS Non-traceable Author Statement more info	PubMed
endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
metalloendopeptidase activity	TAS Traceable Author Statement more info	PubMed
peptidase activity	IDA Inferred from Direct Assay more info	PubMed
protease binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	NAS Non-traceable Author Statement more info	PubMed
protein homodimerization activity	NAS Non-traceable Author Statement more info	PubMed
serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to serine-type peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
serine-type peptidase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of extracellular matrix disassembly	IDA Inferred from Direct Assay more info	PubMed
proteolysis	IEA Inferred from Electronic Annotation more info
regulation of fibrinolysis	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	NAS Non-traceable Author Statement more info	PubMed
invadopodium membrane	IEA Inferred from Electronic Annotation more info
lamellipodium	IDA Inferred from Direct Assay more info	PubMed
lamellipodium membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: seprase

Names: seprase; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027991.1 RefSeqGene

Range

5001..77846

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004460.2 → NP_004451.2 seprase

Status: REVIEWED

Source sequence(s)

U09278

Consensus CDS

CCDS33311.1

UniProtKB/Swiss-Prot

Q12884

Related

ENSP00000188790, OTTHUMP00000204566, ENST00000188790, OTTHUMT00000332852

Conserved Domains (3) summary

COG1506
Location:504 – 757
Blast Score: 386

DAP2; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]

pfam00326
Location:553 – 759
Blast Score: 524

Peptidase_S9; Prolyl oligopeptidase family

pfam00930
Location:106 – 473
Blast Score: 970

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p10 Primary Assembly

Range

163027200..163100045, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

154909562..154982406, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018913.1 Alternate CHM1_1.0

Range

162423993..162496839, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01004891.1 (117105..189949)	None
genomic	AC007750.3	AAY24205.1
genomic	AMYH01011214.1 (638415..711261)	None
genomic	CH471058.2	EAX11353.1
		EAX11354.1
mRNA	AK055327.1	None
mRNA	AK297118.1	BAG59624.1
mRNA	AK309260.1	None
mRNA	AK310293.1	None
mRNA	AK315448.1	BAG37836.1
mRNA	AL832166.1	None
mRNA	BC026250.1	AAH26250.1
mRNA	U09278.1	AAB49652.1
mRNA	U76833.1	AAC51668.1
other-genetic	DQ891423.2	ABM82349.1
other-genetic	DQ894597.2	ABM85523.1