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Tle1 transducin-like enhancer of split 1 [ Mus musculus (house mouse) ]

Gene ID: 21885, updated on 21-May-2016
Official Symbol
Tle1provided by MGI
Official Full Name
transducin-like enhancer of split 1provided by MGI
Primary source
MGI:MGI:104636
See related
Ensembl:ENSMUSG00000008305 Vega:OTTMUSG00000000333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grg1; Grg-1; Tle4l; Estm14; C230057C06Rik
Orthologs
Location:
4; 4 C3
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (72109945..72200893, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (71778176..71861953, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102634852 Neighboring gene predicted gene 11231 Neighboring gene RIKEN cDNA C630043F03 gene Neighboring gene aldolase 1 A, retrogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA polymerase II transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transducin-like enhancer protein 1
Names
groucho-related protein 1
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285529.1NP_001272458.1  transducin-like enhancer protein 1 isoform b

    See identical proteins and their annotated locations for NP_001272458.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK044642, AL845340, BC057573, BM939470, BX640475
    UniProtKB/TrEMBL
    Q6PFG2
    Conserved Domains (3) summary
    COG2319
    Location:475767
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:482766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1134
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  2. NM_001285530.1NP_001272459.1  transducin-like enhancer protein 1 isoform c

    See identical proteins and their annotated locations for NP_001272459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (c, also known as Grg1-LDGP) is shorter than isoform a.
    Source sequence(s)
    AK044642, AK052961, AK082499, AL845340, BM939470, BX640475
    UniProtKB/Swiss-Prot
    Q62440
    Conserved Domains (3) summary
    COG2319
    Location:402694
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:409693
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1127
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  3. NM_001285531.1NP_001272460.1  transducin-like enhancer protein 1 isoform d

    See identical proteins and their annotated locations for NP_001272460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several exons in the central and 3' coding regions, but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AK044642, AK046402
    Consensus CDS
    CCDS71407.1
    UniProtKB/Swiss-Prot
    Q62440
    Related
    ENSMUSP00000102960, OTTMUSP00000000388, ENSMUST00000107337, OTTMUST00000000847
    Conserved Domains (1) summary
    pfam03920
    Location:1135
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  4. NM_001285532.1NP_001272461.1  transducin-like enhancer protein 1 isoform e

    See identical proteins and their annotated locations for NP_001272461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks several exons in the central and 3' coding regions, but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e, also known as Grg1-S) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AK044642, AK046402, AY155196
    UniProtKB/Swiss-Prot
    Q62440
    Conserved Domains (1) summary
    pfam03920
    Location:1134
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  5. NM_011599.5NP_035729.3  transducin-like enhancer protein 1 isoform a

    See identical proteins and their annotated locations for NP_035729.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as Grg1-L).
    Source sequence(s)
    AK044642, AK048515, AK082499, AL845340, BM939470, BX640475
    Consensus CDS
    CCDS18274.1
    UniProtKB/Swiss-Prot
    Q62440
    UniProtKB/TrEMBL
    Q5SQA2
    Related
    ENSMUSP00000072481, OTTMUSP00000000387, ENSMUST00000072695, OTTMUST00000000846
    Conserved Domains (3) summary
    COG2319
    Location:476768
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:483767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1135
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    72109945..72200893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537764.2XP_006537827.1  

    Conserved Domains (3) summary
    COG2319
    Location:430722
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:437721
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:189
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  2. XM_006537760.1XP_006537823.1  

    UniProtKB/TrEMBL
    Q5SQA4
    Related
    ENSMUSP00000099912, OTTMUSP00000000391, ENSMUST00000102848, OTTMUST00000000851
    Conserved Domains (3) summary
    COG2319
    Location:483775
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:490774
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  3. XM_006537759.1XP_006537822.1  

    See identical proteins and their annotated locations for XP_006537822.1

    Conserved Domains (3) summary
    COG2319
    Location:485777
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:492776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1145
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  4. XM_006537758.1XP_006537821.1  

    UniProtKB/TrEMBL
    Q5SQA3
    Related
    ENSMUSP00000030095, OTTMUSP00000000393, ENSMUST00000030095, OTTMUST00000000853
    Conserved Domains (3) summary
    COG2319
    Location:486778
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:493777
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1145
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  5. XM_011249986.1XP_011248288.1  

    Conserved Domains (3) summary
    COG2319
    Location:474766
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:481765
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1134
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  6. XM_006537761.1XP_006537824.1  

    See identical proteins and their annotated locations for XP_006537824.1

    Conserved Domains (3) summary
    COG2319
    Location:475767
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:482766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1135
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  7. XM_006537766.2XP_006537829.1  

    Conserved Domains (3) summary
    COG2319
    Location:356648
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:363647
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:179
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  8. XM_011249985.1XP_011248287.1  

    Conserved Domains (3) summary
    COG2319
    Location:364656
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:371655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:187
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  9. XM_011249983.1XP_011248285.1  

    Conserved Domains (3) summary
    COG2319
    Location:438730
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:445729
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:185
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  10. XM_011249984.1XP_011248286.1  

    Conserved Domains (3) summary
    COG2319
    Location:410702
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:417701
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1135
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  11. XM_011249982.1XP_011248284.1  

    Conserved Domains (3) summary
    COG2319
    Location:483775
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:490774
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  12. XM_011249981.1XP_011248283.1  

    Conserved Domains (3) summary
    COG2319
    Location:484776
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:491775
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  13. XM_011249979.1XP_011248281.1  

    Conserved Domains (3) summary
    COG2319
    Location:493785
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:500784
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  14. XM_011249980.1XP_011248282.1  

    Conserved Domains (3) summary
    COG2319
    Location:493785
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:500784
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1153
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  15. XM_011249978.1XP_011248280.1  

    Conserved Domains (3) summary
    COG2319
    Location:494786
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:501785
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1153
    TLE_N; Groucho/TLE N-terminal Q-rich domain

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    70696582..70787444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)