Format

Send to:

Choose Destination

Tjp2 tight junction protein 2 [ Mus musculus (house mouse) ]

Gene ID: 21873, updated on 8-May-2016
Official Symbol
Tjp2provided by MGI
Official Full Name
tight junction protein 2provided by MGI
Primary source
MGI:MGI:1341872
See related
Ensembl:ENSMUSG00000024812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZO-2
Orthologs
Location:
19; 19 C1
Exon count:
27
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (24094502..24225128, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (24168992..24299444, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41823 Neighboring gene predicted gene, 41824 Neighboring gene frataxin Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
TNFSF11-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
 
intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoclast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane permeability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
gap junction ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tight junction protein ZO-2
Names
Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2)
zona occludens protein 2
zonula occludens protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198985.1NP_001185914.1  tight junction protein ZO-2 isoform 1

    See identical proteins and their annotated locations for NP_001185914.1

    Status: VALIDATED

    Description
    Transcript Variant: Thsi variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK028494, BM224980, BP767126, BQ176958, CB724174, CF736959, CN527767, CN529621
    Conserved Domains (3) summary
    cd12027
    Location:607669
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:705884
    GuKc; Guanylate kinase homologues
    cd00992
    Location:32117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_011597.4NP_035727.2  tight junction protein ZO-2 isoform 2

    See identical proteins and their annotated locations for NP_035727.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 5' terminal exon which results in the use of a downstream translation initiation site, compared to variant 1. Variant 2 encodes an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK028494, BM224980, BP767126, BQ176958, BY032291, CB724174, CF736959, CN527767, CN529621
    Consensus CDS
    CCDS37939.1
    UniProtKB/Swiss-Prot
    Q9Z0U1
    Related
    ENSMUSP00000097154, ENSMUST00000099558
    Conserved Domains (3) summary
    cd12027
    Location:584646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682861
    GuKc; Guanylate kinase homologues
    cd00992
    Location:994
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    24094502..24225128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526908.2XP_006526971.1  

    See identical proteins and their annotated locations for XP_006526971.1

    UniProtKB/Swiss-Prot
    Q9Z0U1
    Conserved Domains (3) summary
    cd12027
    Location:584646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682861
    GuKc; Guanylate kinase homologues
    cd00992
    Location:994
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_011247219.1XP_011245521.1  

    See identical proteins and their annotated locations for XP_011245521.1

    UniProtKB/Swiss-Prot
    Q9Z0U1
    Conserved Domains (3) summary
    cd12027
    Location:584646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682861
    GuKc; Guanylate kinase homologues
    cd00992
    Location:994
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_006526909.1XP_006526972.1  

    Conserved Domains (3) summary
    cd12027
    Location:611673
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:709888
    GuKc; Guanylate kinase homologues
    cd00992
    Location:36121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_006526905.1XP_006526968.1  

    Conserved Domains (3) summary
    cd12027
    Location:611673
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:709888
    GuKc; Guanylate kinase homologues
    cd00992
    Location:36121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_006526907.2XP_006526970.1  

    Conserved Domains (3) summary
    cd12027
    Location:625687
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:723902
    GuKc; Guanylate kinase homologues
    cd00992
    Location:50135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_006526904.2XP_006526967.1  

    Conserved Domains (3) summary
    cd12027
    Location:625687
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:723902
    GuKc; Guanylate kinase homologues
    cd00992
    Location:50135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    24858437..24990744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)