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Trim28 tripartite motif-containing 28 [ Mus musculus (house mouse) ]

Gene ID: 21849, updated on 28-May-2016
Official Symbol
Trim28provided by MGI
Official Full Name
tripartite motif-containing 28provided by MGI
Primary source
MGI:MGI:109274
See related
Ensembl:ENSMUSG00000005566 Vega:OTTMUSG00000023882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAP-1; Tif1b; KRIP-1; MommeD9; AA408787; Tif1beta
Orthologs
Location:
7; 7 A2
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (13024152..13031032)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (13609501..13616381)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 (fatty acid transporter), member 5 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene predicted gene, 31649 Neighboring gene charged multivesicular body protein 2A Neighboring gene ubiquitin-conjugating enzyme E2M

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC102100

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
Krueppel-associated box domain binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
chromo shadow domain binding ISO
Inferred from Sequence Orthology
more info
 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA methylation involved in embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair ISO
Inferred from Sequence Orthology
more info
 
Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
convergent extension involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic placenta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
innate immune response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA demethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
positive regulation of methylation-dependent chromatin silencing ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription factor import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein oligomerization ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
regulation of genetic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
transcription intermediary factor 1-beta
Names
E3 SUMO-protein ligase TRIM28
KRAB-A-interacting protein
TIF1-beta
transcriptional intermediary factor 1, beta
tripartite motif protein 28
tripartite motif-containing protein 28

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011588.3NP_035718.2  transcription intermediary factor 1-beta

    See identical proteins and their annotated locations for NP_035718.2

    Status: VALIDATED

    Source sequence(s)
    BC089337
    Consensus CDS
    CCDS20823.1
    UniProtKB/Swiss-Prot
    Q62318
    UniProtKB/TrEMBL
    Q5EBP9
    Related
    ENSMUSP00000005705, OTTMUSP00000028258, ENSMUST00000005705, OTTMUST00000058340
    Conserved Domains (6) summary
    smart00502
    Location:253379
    BBC; B-Box C-terminal domain
    smart00336
    Location:149185
    BBOX; B-Box-type zinc finger
    cd00021
    Location:208246
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam14634
    Location:65123
    zf-RING_5; zinc-RING finger domain
    cl02556
    Location:696802
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    cd15623
    Location:627669
    PHD_TIF1beta; PHD finger found in transcription intermediary factor 1-beta (TIF1-beta)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    13024152..13031032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    10651338..10658223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)