Format

Send to:

Choose Destination

Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [ Mus musculus (house mouse) ]

Gene ID: 21846, updated on 8-May-2016
Official Symbol
Tie1provided by MGI
Official Full Name
tyrosine kinase with immunoglobulin-like and EGF-like domains 1provided by MGI
Primary source
MGI:MGI:99906
See related
Ensembl:ENSMUSG00000033191 Vega:OTTMUSG00000008793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIE; tie-1; D430008P04Rik
Orthologs
Location:
4 D2.1; 4 54.67 cM
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (118471191..118489849, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (118143796..118162454, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 Neighboring gene cell division cycle 20 Neighboring gene myeloproliferative leukemia virus oncogene Neighboring gene predicted gene 12859 Neighboring gene ribosomal protein S5 pseudogene Neighboring gene predicted gene, 40236

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
plasma membrane fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
integral component of membrane ISM
Inferred from Sequence Model
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tyrosine-protein kinase receptor Tie-1
Names
tyrosine kinase receptor 1
NP_035717.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011587.2NP_035717.2  tyrosine-protein kinase receptor Tie-1 precursor

    See identical proteins and their annotated locations for NP_035717.2

    Status: VALIDATED

    Source sequence(s)
    AK052192, AK052413, BB841681, CR518034
    Consensus CDS
    CCDS18553.1
    UniProtKB/Swiss-Prot
    Q06806
    Related
    ENSMUSP00000037129, OTTMUSP00000009169, ENSMUST00000047421, OTTMUST00000019990
    Conserved Domains (8) summary
    smart00219
    Location:8351103
    TyrKc; Tyrosine kinase, catalytic domain
    smart00409
    Location:367441
    IG; Immunoglobulin
    smart00410
    Location:131210
    IG_like; Immunoglobulin like
    cd00054
    Location:312343
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:225263
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:640732
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:137192
    ig; Immunoglobulin domain
    cd05089
    Location:8321128
    PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    118471191..118489849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    117196542..117215172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)