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Tgfbr3 transforming growth factor, beta receptor III [ Mus musculus (house mouse) ]

Gene ID: 21814, updated on 8-May-2016
Official Symbol
Tgfbr3provided by MGI
Official Full Name
transforming growth factor, beta receptor IIIprovided by MGI
Primary source
MGI:MGI:104637
See related
Ensembl:ENSMUSG00000029287 Vega:OTTMUSG00000028168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TBRIII; AU015626; AW215636; 1110036H20Rik
Orthologs
Location:
5; 5 E5
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (107106570..107289595, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (107535589..107718614, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33474 Neighboring gene predicted gene, 42146 Neighboring gene predicted gene, 33692 Neighboring gene bromodomain, testis-specific Neighboring gene predicted gene 17202 Neighboring gene epoxide hydrolase 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SMAD binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
activin binding ISO
Inferred from Sequence Orthology
more info
 
coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta binding IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor activity, type III ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
blastocyst development IDA
Inferred from Direct Assay
more info
PubMed 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell growth ISO
Inferred from Sequence Orthology
more info
 
collagen metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
coronary vasculature development TAS
Traceable Author Statement
more info
PubMed 
coronary vasculature morphogenesis TAS
Traceable Author Statement
more info
PubMed 
definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development TAS
Traceable Author Statement
more info
PubMed 
epicardial cell to mesenchymal cell transition TAS
Traceable Author Statement
more info
PubMed 
epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cellular component movement ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pathway-restricted SMAD protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of blood vessel size TAS
Traceable Author Statement
more info
PubMed 
regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
response to follicle-stimulating hormone ISO
Inferred from Sequence Orthology
more info
 
response to luteinizing hormone ISO
Inferred from Sequence Orthology
more info
 
response to prostaglandin E ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor complex assembly ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
PubMed 
ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
visceral serous pericardium development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
inhibin-betaglycan-ActRII complex ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
transforming growth factor beta receptor type 3
Names
TGF-beta receptor type 3
TGF-beta receptor type III
TGFR-3
betaglycan

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011578.3NP_035708.2  transforming growth factor beta receptor type 3 precursor

    See identical proteins and their annotated locations for NP_035708.2

    Status: VALIDATED

    Source sequence(s)
    AF039601, AK166082, BC070428
    Consensus CDS
    CCDS19499.1
    UniProtKB/Swiss-Prot
    O88393
    UniProtKB/TrEMBL
    A0A0R4J097, Q3TM82
    Related
    ENSMUSP00000031224, OTTMUSP00000035486, ENSMUST00000031224, OTTMUST00000069768
    Conserved Domains (1) summary
    smart00241
    Location:454723
    ZP; Zona pellucida (ZP) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    107106570..107289595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    104218970..104402013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)