Tgfbr2 transforming growth factor, beta receptor II [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Tgfbr2provided by MGI
Official Full Name: transforming growth factor, beta receptor IIprovided by MGI
Primary source: MGI:98729
See related: Ensembl:ENSMUSG00000032440
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DNIIR; RIIDN; TBR-II; AU042018; TbetaRII; TbetaR-II; 1110020H15Rik

Genomic context

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Location :: 9 F3; 9 68.39 cM

Sequence :: Chromosome: 9; NC_000075.6 (116087695..116175363, complement)

See Tgfbr2 in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study identified two distinct pathways that regulate adult beta-cell proliferation.
Title: TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation.
Loss of Tgfbr2 in hypertrophic chondrocytes using Col10a1-Cre mice resulted in delays in both the hypertrophic conversion of proliferating chondrocytes and terminal chondrocyte differentiation
Title: Conditional deletion of Tgfbr2 in hypertrophic chondrocytes delays terminal chondrocyte differentiation.
IRF6 and SMAD4 synergistically regulate the fate of the medial edge epithelium(MEE), and TGFbeta-mediated Irf6 activity is responsible for MEE degeneration during palatal fusion in mice.
Title: Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice.
c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.
Title: c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.
Deficiency of the TGF-beta type II receptor protected proximal tubule epithelial cells from apoptosis.
Title: Deleting the TGF-β receptor attenuates acute proximal tubule injury.
TGFbetaR2 signaling in dendritic cells is critical to control autoimmunity through both regulatory T (Treg) cell-dependent and -independent mechanisms.
Title: Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.
TGFbeta signalling is essential in vascular endothelial cells for maintaining vascular integrity at the angiogenic front as it migrates into developing neural tissues in early postnatal life.
Title: Endothelial expression of TGFβ type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system.
Results establish a novel role for TGFbeta signaling in expression of genes for alternatively activated macrophages. Lack of TbetaRII signaling may reduce the anti-inflammatory M2 phenotype of macrophages because of reduced expression of these products.
Title: TGFβ signaling plays a critical role in promoting alternative macrophage activation.
Treatment of PyMT/Tgfbr2(KO) mice with anti-IL-17 Ab decreased carcinoma growth and metastatic burden.
Title: TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms.
We conclude that Tgfbr2 in myeloid cells has a negative role in the regulation of anti-tumorigenic functions of these cells
Title: Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties.

Submit: New GeneRIF Correction See all (86)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (4) 1 citation
Targeted (knock-out) (4) 1 citation
Targeted (Reporter) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_033397.2	NP_035707.1	Tgfb1	BIND	PubMed	TGF-beta-1 interacts with Tgfbr2. This interaction was modelled on a demonstrated interaction between TGF-beta-1 from human and Tgfbr2 from mouse.
	NP_034835.1	Lgals3	BIND	PubMed	T-beta-RII interacts with Gal-3.
	NP_032782.1	Ocln	BIND	PubMed	T-beta-RII interacts with OCLN. An unspecified isoform of T-beta-RII interacts with OCLN.
	NP_035629.1	Strap	BIND	PubMed	STRAP interacts with an unspecified isoform of T-beta-R-II. This interaction was modeled on a demonstrated interaction between mouse STRAP and T-beta-R-II from an unspecified species.
	NP_035707.1	Tgfb1	BIND	PubMed	TGF-beta1 interacts with T-beta-RII. This interaction was was modeled on a demonstrated interaction between TGF-beta1 from an unspecified species and T-beta-RII from mouse.
	NP_033396.1	Tgfbr1	BIND	PubMed	T-beta-R1 interacts with an unspecified isoform of T-beta-R2.
BioGRID:204164	BioGRID:204163	Tgfbr1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:204164	BioGRID:204165	Tgfbr3	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Adherens junction, organism-specific biosystem (from KEGG)
Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Adherens junction, conserved biosystem (from KEGG)
Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
Chronic myeloid leukemia, conserved biosystem (from KEGG)
Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
Colorectal cancer, organism-specific biosystem (from KEGG)
Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Colorectal cancer, conserved biosystem (from KEGG)
Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Downregulation of TGF-beta receptor signaling, organism-specific biosystem (from REACTOME)
Downregulation of TGF-beta receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Hippo signaling pathway, organism-specific biosystem (from KEGG)
Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Hippo signaling pathway, conserved biosystem (from KEGG)
Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Pancreatic cancer, organism-specific biosystem (from KEGG)
Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pancreatic cancer, conserved biosystem (from KEGG)
Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
Signaling by TGF-beta Receptor Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem
TGF-beta Receptor Signaling Pathway
TGF-beta receptor signaling activates SMADs, organism-specific biosystem (from REACTOME)
TGF-beta receptor signaling activates SMADs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystem (from REACTOME)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TGF-beta signaling pathway, conserved biosystem (from KEGG)
TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

Tgfbr2 (e-PCR), detects polymorphism
- UniSTS:265759

Tgfbr2 (e-PCR), detects polymorphism
- UniSTS:496701

Tgfbr2 (e-PCR), detects polymorphism
- UniSTS:526948

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AU042018 (e-PCR)
- UniSTS:159931

NoName (e-PCR)
- UniSTS:224191

NoName (e-PCR)
- UniSTS:236275

Homology

Homologs of the Tgfbr2 gene: The Tgfbr2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
SMAD binding	IDA Inferred from Direct Assay more info	PubMed
SMAD binding	ISO Inferred from Sequence Orthology more info
glycosaminoglycan binding	ISO Inferred from Sequence Orthology more info
kinase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info
receptor signaling protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
transforming growth factor beta binding	IPI Inferred from Physical Interaction more info	PubMed
transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
transforming growth factor beta receptor activity, type II	ISO Inferred from Sequence Orthology more info
transforming growth factor beta-activated receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
transforming growth factor beta-activated receptor activity	ISO Inferred from Sequence Orthology more info
transmembrane receptor protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
type III transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
brain development	IMP Inferred from Mutant Phenotype more info	PubMed
bronchus development	IMP Inferred from Mutant Phenotype more info	PubMed
bronchus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
cell differentiation	IEA Inferred from Electronic Annotation more info
common-partner SMAD protein phosphorylation	ISO Inferred from Sequence Orthology more info
embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
heart development	IMP Inferred from Mutant Phenotype more info	PubMed
in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
lens fiber cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
lung development	IMP Inferred from Mutant Phenotype more info	PubMed
lung lobe morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
mammary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
myeloid dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
organ morphogenesis	ISO Inferred from Sequence Orthology more info
palate development	IMP Inferred from Mutant Phenotype more info	PubMed
pathway-restricted SMAD protein phosphorylation	ISO Inferred from Sequence Orthology more info
patterning of blood vessels	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of B cell tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of NK T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of T cell tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of tolerance induction to self antigen	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of growth	IEA Inferred from Electronic Annotation more info
response to cholesterol	IDA Inferred from Direct Assay more info	PubMed
response to cholesterol	ISO Inferred from Sequence Orthology more info
response to drug	ISO Inferred from Sequence Orthology more info
signal transduction by phosphorylation	IEA Inferred from Electronic Annotation more info
smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
trachea formation	IMP Inferred from Mutant Phenotype more info	PubMed
trachea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
transmembrane receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
caveola	ISO Inferred from Sequence Orthology more info	PubMed
cell surface	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
external side of plasma membrane	ISO Inferred from Sequence Orthology more info
integral to membrane	ISO Inferred from Sequence Orthology more info
integral to plasma membrane	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
membrane raft	ISO Inferred from Sequence Orthology more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info
receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TGF-beta receptor type-2

Names: TGF-beta receptor type-2; TGFR-2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta type II receptor; transforming growth factor-beta receptor type II

NP_033397.3

EC 2.7.11.30

NP_083851.3

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009371.3 → NP_033397.3 TGF-beta receptor type-2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK046561, AK053793, CO039384

Consensus CDS

CCDS23601.1

UniProtKB/TrEMBL

Q543C0

UniProtKB/Swiss-Prot

Q62312

UniProtKB/TrEMBL

Q8BQS9

Related

ENSMUSP00000062333, ENSMUST00000061101

Conserved Domains (4) summary

pfam08917
Location:72 – 176
Blast Score: 483

ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

cd00180
Location:275 – 482
Blast Score: 365

PKc; Catalytic domain of Protein Kinases

pfam00069
Location:269 – 569
Blast Score: 462

Pkinase; Protein kinase domain

cl09925
Location:400 – 569
Blast Score: 100

PKc_like; Protein Kinases, catalytic domain
NM_029575.3 → NP_083851.3 TGF-beta receptor type-2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK046561, AK053793, AK148167, CO039384

Consensus CDS

CCDS23602.1

UniProtKB/TrEMBL

Q3UG22

UniProtKB/TrEMBL

Q543C0

UniProtKB/TrEMBL

Q8BQS9

Related

ENSMUSP00000035014, ENSMUST00000035014

Conserved Domains (4) summary

pfam08917
Location:47 – 151
Blast Score: 483

ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

cd00180
Location:250 – 457
Blast Score: 366

PKc; Catalytic domain of Protein Kinases

pfam00069
Location:244 – 544
Blast Score: 463

Pkinase; Protein kinase domain

cl09925
Location:375 – 544
Blast Score: 100

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38.p1 C57BL/6J

Range

116087695..116175363, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

116548860..116637499, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01082123.1	None
genomic	AAHY01082124.1	None
genomic	AAHY01082125.1	None
genomic	AAHY01082126.1	None
genomic	AAHY01082127.1	None
genomic	AAHY01082128.1	None
genomic	AAHY01082129.1	None
genomic	AAHY01082130.1	None
genomic	AAHY01082131.1 (1670..13406)	None
genomic	AC131777.2 (15447..103029)	None
genomic	AF118264.1	AAF27281.1	129/Ola
genomic	CH466587.2	EDL09274.1	mixed
		EDL09275.1	mixed
mRNA	AF406755.1	AAK98605.1	BALB/cAnPtD
mRNA	AK003861.1	None	C57BL/6J
mRNA	AK043619.1	BAC31597.1	C57BL/6J
mRNA	AK046561.1	BAC32788.1	C57BL/6J
mRNA	AK053793.1	BAC35526.1	C57BL/6J
mRNA	AK090393.1	None	C57BL/6J
mRNA	AK148167.1	BAE28387.1	C57BL/6J
mRNA	AK159327.1	BAE34993.1	C57BL/6J
mRNA	BC016262.1	AAH16262.1	FVB/N
mRNA	BC052629.1	None
mRNA	CO039384.1	None	C57BL/6J
mRNA	S69114.1	AAB30100.2	Swiss Webster