Tgfb1i1 transforming growth factor beta 1 induced transcript 1 [Mus musculus] - Gene

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Summary

Official Symbol: Tgfb1i1provided by MGI
Official Full Name: transforming growth factor beta 1 induced transcript 1provided by MGI
Primary source: MGI:102784
See related: Ensembl:ENSMUSG00000030782; Vega:OTTMUSG00000036582
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hic5; ARA55; TSC-5; hic-5

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Genomic context

Location :: 7; 7 F1-F3

Sequence :: Chromosome: 7; NC_000073.6 (128246871..128253712)

See Tgfb1i1 in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein.
Title: Transforming growth factor-β1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein.
DNA-binding domain acetylation in the TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation
Title: Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation.
Findings indicate that Hic-5 may serve as a key regulator in mechanosensitive vascular remodeling.
Title: Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling.
Hic-5/ARA55 expression in response to castration-enabled epithelial regression through the repression of c-myc gene at the chromatin level.
Title: Epithelial Hic-5/ARA55 expression contributes to prostate tumorigenesis and castrate responsiveness.
These data suggest that the reduced expression of Hic-5 and concomitant reduced CTGF promoter activity may contribute to the anti-angiogenic effects of histone deacetylase inhibitors.
Title: Hic-5 as a regulator of endothelial cell morphology and connective tissue growth factor gene expression.
These findings demonstrate a novel role for hic-5 in the regulation of actin cytoskeleton and fetal gene expression.
Title: Hic-5 is required for fetal gene expression and cytoskeletal organization of neonatal cardiac myocytes.
Data demonstrate that anchorage dependence is determined by anchorage-dependent nuclear retention of cyclin D1, which is regulated by the focal adhesion protein, Hic-5, whose CRM1-dependent nuclear export counteracts that of cyclin D1.
Title: Competitive nuclear export of cyclin D1 and Hic-5 regulates anchorage dependence of cell growth and survival.
These results suggest that Hic-5 modulates cellular responses to pathological stimuli in the vessel wall.
Title: Hic-5, an adaptor protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo.
demonstrate differential roles for individual Hic-5 isoforms during myogenesis and support the hypothesis that Hic-5 mediates these effects via integrin signaling.
Title: Differential roles of HIC-5 isoforms in the regulation of cell death and myotube formation during myogenesis.
Repressive interference of LEF/TCF family members with HIC-5-mediated activation of glucocorticoid-driven transcription.
Title: HIC-5 is a novel repressor of lymphoid enhancer factor/T-cell factor-driven transcription.

Submit: New GeneRIF Correction See all (17)

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:204158	BioGRID:229822	Git1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:204158	BioGRID:111719	PTK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:204158	BioGRID:112422	SLC6A3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:204158	BioGRID:205124	Tlx3	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
I-SMAD binding	ISO Inferred from Sequence Orthology more info
Roundabout binding	ISO Inferred from Sequence Orthology more info
androgen receptor binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transcription coactivator activity	ISO Inferred from Sequence Orthology more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
epithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
response to heat	ISO Inferred from Sequence Orthology more info
ubiquitin-dependent SMAD protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
focal adhesion	IDA Inferred from Direct Assay more info	PubMed
intracellular	ISO Inferred from Sequence Orthology more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: transforming growth factor beta-1-induced transcript 1 protein

Names: transforming growth factor beta-1-induced transcript 1 protein; TGF beta-stimulated clone 5; hydrogen peroxide-inducible clone 5 protein; androgen receptor-associated protein of 55 kDa

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009365.2 → NP_033391.1 transforming growth factor beta-1-induced transcript 1 protein

Status: PROVISIONAL

Source sequence(s)

BC056362

Consensus CDS

CCDS21893.1

UniProtKB/Swiss-Prot

Q62219

Related

ENSMUSP00000068529, OTTMUSP00000052125, ENSMUST00000070656, OTTMUST00000093808

Conserved Domains (2) summary

cd09412
Location:388 – 439
Blast Score: 234

LIM4_Leupaxin; The fourth LIM domain of Leupaxin

cl02475
Location:329 – 381
Blast Score: 261

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers.

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38 C57BL/6J

Range

128246871..128253712

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

128082355..128089196

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC124566.5 (35393..42234)	None
genomic	AF083064.1	AAD51090.1
genomic	CH466531.1	EDL17638.1	mixed
		EDL17639.1	mixed
		EDL17640.1	mixed
mRNA	AK003170.1	None	C57BL/6J
mRNA	AK041233.1	None	C57BL/6J
mRNA	AK085042.1	None	C57BL/6J
mRNA	AK087114.1	None	C57BL/6J
mRNA	AK156423.1	BAE33707.1	NOD
mRNA	AK158409.1	BAE34493.1	C57BL/6J
mRNA	BC002049.1	AAH02049.1
mRNA	BC056362.1	AAH56362.1	C57BL/6
mRNA	DQ143891.1	AAZ82195.1	BALB/c
mRNA	DQ143892.1	AAZ82196.1	BALB/c
mRNA	DQ143893.1	AAZ82197.1	BALB/c
mRNA	DQ143894.1	AAZ82198.1	BALB/c
mRNA	DQ143895.1	AAZ82199.1	BALB/c
mRNA	DQ143896.1	AAZ82200.1	BALB/c
mRNA	DQ143897.1	AAZ82201.1	BALB/c
mRNA	DQ143898.1	AAZ82202.1	BALB/c
mRNA	DQ143899.1	AAZ82203.1	BALB/c
mRNA	DQ143900.1	AAZ82204.1	BALB/c
mRNA	L22482.1	AAA62226.1