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Tgfb1 transforming growth factor, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 21803, updated on 3-May-2015
Official Symbol
Tgfb1provided by MGI
Official Full Name
transforming growth factor, beta 1provided by MGI
Primary source
MGI:MGI:98725
See related
Ensembl:ENSMUSG00000002603; Vega:OTTMUSG00000036027
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tgfb; Tgfb-1; TGFbeta1; TGF-beta1
Orthologs
See Tgfb1 in MapViewer
Location:
7 A3; 7 13.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (25687002..25704996)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26472021..26490015)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 91 Neighboring gene B9 protein domain 2 Neighboring gene coiled-coil domain containing 97 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, organism-specific biosystem (from WikiPathways)
    Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
    Cell cycle signaling pathway, organism-specific biosystem
    Cell cycle signaling pathway
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
    Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
  • Chronic myeloid leukemia, conserved biosystem (from KEGG)
    Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokines and Inflammatory Response (BioCarta), organism-specific biosystem (from WikiPathways)
    Cytokines and Inflammatory Response (BioCarta), organism-specific biosystemSee BioCarta version: http://www.biocarta.com/pathfiles/h_inflamPathway.asp
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dopminergic Neurogenesis, organism-specific biosystem (from WikiPathways)
    Dopminergic Neurogenesis, organism-specific biosystemhttp://www.michaeljfox.org/research_MJFFfundingPortfolio_searchableAwardedGrants_3.cfm?ID=141
  • Downregulation of TGF-beta receptor signaling, organism-specific biosystem (from REACTOME)
    Downregulation of TGF-beta receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • ECM proteoglycans, organism-specific biosystem (from REACTOME)
    ECM proteoglycans, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Elastic fibre formation, organism-specific biosystem (from REACTOME)
    Elastic fibre formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
    Endochondral Ossification, organism-specific biosystem
    Endochondral Ossification
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
    Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
    Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Leishmaniasis, organism-specific biosystem (from KEGG)
    Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Leishmaniasis, conserved biosystem (from KEGG)
    Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
  • Molecules associated with elastic fibres, organism-specific biosystem (from REACTOME)
    Molecules associated with elastic fibres, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Mus musculus biological processes, organism-specific biosystem (from REACTOME)
    Mus musculus biological processes, organism-specific biosystemCertain mouse pathways have been fully manually curated in Reactome in order to support the manual inference of well-conserved but less well-studied human pathways. These pathways include Circadian...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
    Non-integrin membrane-ECM interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Pancreatic cancer, organism-specific biosystem (from KEGG)
    Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pancreatic cancer, conserved biosystem (from KEGG)
    Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
    PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Renal cell carcinoma, organism-specific biosystem (from KEGG)
    Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
  • Renal cell carcinoma, conserved biosystem (from KEGG)
    Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
    Signaling by TGF-beta Receptor Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • Syndecan interactions, organism-specific biosystem (from REACTOME)
    Syndecan interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem
    TGF-beta Receptor Signaling Pathway
  • TGF-beta receptor signaling activates SMADs, organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling activates SMADs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF-beta signaling, organism-specific biosystem (from KEGG)
    TGF-beta signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • TGF-beta signaling, conserved biosystem (from KEGG)
    TGF-beta signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes, organism-specific biosystemThe differentiation of mouse NIH3T3-L1 pre-adipocytes into adipocytes is the standard model system for adipogenesis.
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
antigen binding ISO
Inferred from Sequence Orthology
more info
 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
glycoprotein binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding TAS
Traceable Author Statement
more info
PubMed 
type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
type III transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment TAS
Traceable Author Statement
more info
PubMed 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
SMAD protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
SMAD protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
T-helper 17 cell lineage commitment TAS
Traceable Author Statement
more info
PubMed 
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IDA
Inferred from Direct Assay
more info
PubMed 
branch elongation involved in mammary gland duct branching IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell activation IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
cell growth IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
common-partner SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
defense response to fungus, incompatible interaction ISO
Inferred from Sequence Orthology
more info
 
endoderm development IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
evasion or tolerance of host defenses by virus ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix assembly IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
germ cell migration IDA
Inferred from Direct Assay
more info
PubMed 
growth IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland branching involved in thelarche IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland development IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle checkpoint ISO
Inferred from Sequence Orthology
more info
 
mononuclear cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of a branching structure ISO
Inferred from Sequence Orthology
more info
 
myelination ISO
Inferred from Sequence Orthology
more info
 
myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
negative regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
organ regeneration ISO
Inferred from Sequence Orthology
more info
 
pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphate-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of SMAD protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of isotype switching to IgA isotypes ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of odontogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of actin cytoskeleton reorganization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of branching involved in mammary gland duct morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-23 production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulatory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
response to progesterone ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
tolerance induction to self antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
blood microparticle ISO
Inferred from Sequence Orthology
more info
 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microvillus ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
transforming growth factor beta-1
Names
transforming growth factor beta-1
TGF-beta 1
TGF-beta-1
regulatory protein
transforming growth factor-beta 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011577.1NP_035707.1  transforming growth factor beta-1 precursor

    See identical proteins and their annotated locations for NP_035707.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ009862
    Consensus CDS
    CCDS20993.1
    UniProtKB/Swiss-Prot
    P04202
    UniProtKB/TrEMBL
    Q3UNK5
    Related
    ENSMUSP00000002678, OTTMUSP00000051111, ENSMUST00000002678, OTTMUST00000092468
    Conserved Domains (2) summary
    pfam00019
    Location:290390
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:28261
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    25687002..25704996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    20295914..20313908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)