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Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 [ Mus musculus (house mouse) ]

Gene ID: 217944, updated on 28-May-2016
Official Symbol
Rapgef5provided by MGI
Official Full Name
Rap guanine nucleotide exchange factor (GEF) 5provided by MGI
Primary source
MGI:MGI:2444365
See related
Ensembl:ENSMUSG00000041992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GFR; Mrgef; C86120; mmr-gef; mKIAA0277; 4932413M22; D030051B22Rik
Orthologs
Location:
12; 12 F2
Exon count:
29
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (117516479..117759737)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (118754952..118995451)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39560 Neighboring gene predicted gene, 31482 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 pseudogene Neighboring gene cell division cycle associated 7 like Neighboring gene dynein, axonemal, heavy chain 11 Neighboring gene trans-acting transcription factor 4 Neighboring gene predicted gene, 39561

  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
Rap guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
rap guanine nucleotide exchange factor 5
Names
M-Ras-regulated Rap GEF
MR-GEF
Mras regulated guanine nucleotide exchange factor
guanine nucleotide exchange factor for Rap1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175930.5NP_787126.3  rap guanine nucleotide exchange factor 5

    See identical proteins and their annotated locations for NP_787126.3

    Status: VALIDATED

    Source sequence(s)
    AC139993, AC163286, AK029995
    Consensus CDS
    CCDS36577.1
    UniProtKB/Swiss-Prot
    Q8C0Q9
    Related
    ENSMUSP00000105313, ENSMUST00000109691
    Conserved Domains (3) summary
    cd06224
    Location:309432
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00155
    Location:574809
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd04437
    Location:33156
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    117516479..117759737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515781.2XP_006515844.1  

    Conserved Domains (3) summary
    cd06224
    Location:417540
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00155
    Location:682917
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd04437
    Location:141264
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

Alternate Mm_Celera

Genomic

  1. NW_001037246.1 Alternate Mm_Celera

    Range
    1513744..1761288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)