Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 [Mus musculus] - Gene

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Summary

Official Symbol: Serpina10provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10provided by MGI
Primary source: MGI:2667725
See related: Ensembl:ENSMUSG00000061947; Vega:OTTMUSG00000026297
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PZI; ZPI; MGC25863

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Genomic context

Location :: 12 E; 12

Sequence :: Chromosome: 12; NC_000078.6 (103616675..103631405, complement)

See Serpina10 in Epigenomics, MapViewer

Chromosome 12 - NC_000078.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

activation of the ATF6 pathway of the UPR limits ATZ-dependent cell toxicity by selectively promoting ER-associated degradation of ATZ
Title: Activating transcription factor 6 limits intracellular accumulation of mutant α(1)-antitrypsin Z and mitochondrial damage in hepatoma cells.
PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype.
Title: Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation

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Function	Evidence Code	Pubs
peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: protein Z-dependent protease inhibitor

Names: protein Z-dependent protease inhibitor; serpin A10; PZ-dependent protease inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144834.3 → NP_659083.2 protein Z-dependent protease inhibitor precursor

Status: PROVISIONAL

Source sequence(s)

AC125360

Consensus CDS

CCDS26134.1

UniProtKB/Swiss-Prot

Q8R121

Related

ENSMUSP00000048357, OTTMUSP00000032368, ENSMUST00000044231, OTTMUST00000065055

Conserved Domains (2) summary

PHA02660
Location:86 – 445
Blast Score: 197

PHA02660; serpin-like protein; Provisional

cl00137
Location:78 – 442
Blast Score: 1432

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000078.6 Reference GRCm38 C57BL/6J

Range

103616675..103631405, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000034.1 Alternate Mm_Celera

Range

104832950..104847686, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC125360.4 (116825..131556)	None
genomic	CH466549.2	EDL18822.1	mixed
		EDL18823.1	mixed
mRNA	AK050552.1	None	C57BL/6J
mRNA	AY324633.1	AAP87100.1	BALB/c
mRNA	BC018416.1	AAH18416.1	FVB/N
mRNA	BC025821.1	AAH25821.1	FVB/N