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Tert telomerase reverse transcriptase [ Mus musculus (house mouse) ]

Gene ID: 21752, updated on 28-May-2016
Official Symbol
Tertprovided by MGI
Official Full Name
telomerase reverse transcriptaseprovided by MGI
Primary source
MGI:MGI:1202709
See related
Ensembl:ENSMUSG00000021611
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TR; TP2; TRT; EST2; TCS1
Orthologs
Location:
13 C1; 13 40.12 cM
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (73626797..73649843)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (73764449..73786489)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Neighboring gene CLPTM1-like Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 18 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19, opposite strand

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC150124

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to RNA-directed RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
tRNA binding ISO
Inferred from Sequence Orthology
more info
 
telomerase RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
 
telomerase RNA reverse transcriptase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
telomerase RNA reverse transcriptase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to telomerase RNA reverse transcriptase activity ISO
Inferred from Sequence Orthology
more info
 
telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
telomerase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to telomerase activity ISO
Inferred from Sequence Orthology
more info
 
telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
DNA strand elongation ISO
Inferred from Sequence Orthology
more info
 
RNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
RNA-dependent DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to telomere ISO
Inferred from Sequence Orthology
more info
 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of production of siRNA involved in RNA interference ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hair cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transdifferentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
production of siRNA involved in RNA interference ISO
Inferred from Sequence Orthology
more info
 
regulation of histone demethylase activity (H3-K4 specific) TAS
Traceable Author Statement
more info
PubMed 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
replicative senescence ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
 
telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
transcription, RNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with PML body ISO
Inferred from Sequence Orthology
more info
 
RNA-directed RNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 
TERT-RMRP complex ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
telomerase catalytic core complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomerase catalytic core complex ISO
Inferred from Sequence Orthology
more info
 
telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
telomerase reverse transcriptase
Names
telomerase catalytic subunit
telomerase reverse transcriptase beta
NP_033380.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009354.1NP_033380.1  telomerase reverse transcriptase

    See identical proteins and their annotated locations for NP_033380.1

    Status: PROVISIONAL

    Source sequence(s)
    AF051911
    Consensus CDS
    CCDS26633.1
    UniProtKB/Swiss-Prot
    O70372
    Related
    ENSMUSP00000022104, ENSMUST00000022104
    Conserved Domains (2) summary
    smart00975
    Location:450584
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:815929
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    73626797..73649843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517210.2XP_006517273.1  

    Conserved Domains (2) summary
    smart00975
    Location:450584
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:815929
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
  2. XM_006517211.2XP_006517274.1  

    Conserved Domains (2) summary
    smart00975
    Location:450582
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:580693
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
  3. XM_006517212.2XP_006517275.1  

    Conserved Domains (2) summary
    smart00975
    Location:57191
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:422536
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
  4. XM_006517213.2XP_006517276.1  

    See identical proteins and their annotated locations for XP_006517276.1

    UniProtKB/TrEMBL
    A0JNY9
    Conserved Domains (2) summary
    cd01648
    Location:277391
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
    cl13446
    Location:146
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
  5. XM_006517214.2XP_006517277.1  

    Conserved Domains (1) summary
    cd01648
    Location:210324
    TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...

RNA

  1. XR_382432.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    75955877..75977918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)