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FABP6 fatty acid binding protein 6 [ Homo sapiens (human) ]

Gene ID: 2172, updated on 12-May-2016
Official Symbol
FABP6provided by HGNC
Official Full Name
fatty acid binding protein 6provided by HGNC
Primary source
HGNC:HGNC:3561
See related
Ensembl:ENSG00000170231 HPRD:02689; MIM:600422; Vega:OTTHUMG00000130329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILBP; I-15P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB
Summary
This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
5q33.3-q34
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (160187367..160238722)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159614374..159665729)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene adrenoceptor alpha 1B Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 40 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene PWWP domain containing 2A Neighboring gene uncharacterized LOC105377690 Neighboring gene uncharacterized LOC105377691 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene cyclin J like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Bile acid and bile salt metabolism, organism-specific biosystem (from REACTOME)
    Bile acid and bile salt metabolism, organism-specific biosystemIn a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily. Newly synthesized bile salts are secreted into the bile and released into the small intestine where they emulsi...
  • Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystem (from REACTOME)
    Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystemTriacylglycerol is a major energy store in the body and its hydrolysis to yield fatty acids and glycerol is a tightly regulated part of energy metabolism. A central part in this regulation is played ...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Recycling of bile acids and salts, organism-specific biosystem (from REACTOME)
    Recycling of bile acids and salts, organism-specific biosystemOf the 20-40 grams of bile salts released daily by the liver, all but approximately 0.5 grams are reabsorbed from the intestine, returned to the liver, and re-used. This recycling involves a series o...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bile acid binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding TAS
Traceable Author Statement
more info
PubMed 
transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
bile acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
triglyceride catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
gastrotropin
Names
GT
fatty acid binding protein 6, ileal
ileal bile acid binding protein
ileal lipid-binding protein
illeal lipid-binding protein
intestinal 15 kDa protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029500.1 RefSeqGene

    Range
    5001..56356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040442.1NP_001035532.1  gastrotropin isoform 1

    See identical proteins and their annotated locations for NP_001035532.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AI208231, BC022489, X90908
    Consensus CDS
    CCDS43393.1
    UniProtKB/Swiss-Prot
    P51161
    Conserved Domains (1) summary
    pfam14651
    Location:52177
    Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family
  2. NM_001130958.1NP_001124430.1  gastrotropin isoform 1

    See identical proteins and their annotated locations for NP_001124430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional 5' exon, as compared to variant 1. Both variants 1 and 3 encode the same isoform 1.
    Source sequence(s)
    BC022489, DQ132786
    Consensus CDS
    CCDS43393.1
    UniProtKB/Swiss-Prot
    P51161
    Related
    ENSP00000377549, OTTHUMP00000160846, ENST00000393980, OTTHUMT00000252678
    Conserved Domains (1) summary
    pfam14651
    Location:52177
    Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family
  3. NM_001445.2NP_001436.1  gastrotropin isoform 2

    See identical proteins and their annotated locations for NP_001436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons and has an alternate 5' sequence, and the translation initiation starts from a downstream AUG codon, as compared to variant 1. The encoded protein (isoform 2) is dominant and shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    BC022489, X90908
    Consensus CDS
    CCDS4349.1
    UniProtKB/Swiss-Prot
    P51161
    Related
    ENSP00000385433, OTTHUMP00000198697, ENST00000402432, OTTHUMT00000320505
    Conserved Domains (1) summary
    pfam14651
    Location:3128
    Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    160187367..160238722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534463.1XP_011532765.1  

    Conserved Domains (1) summary
    pfam14651
    Location:24149
    Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family
  2. XM_006714830.2XP_006714893.1  

    See identical proteins and their annotated locations for XP_006714893.1

    UniProtKB/Swiss-Prot
    P51161
    Conserved Domains (1) summary
    pfam14651
    Location:3128
    Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    159047368..159098746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)