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    Gls2 glutaminase 2 (liver, mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 216456, updated on 18-May-2013
    Official Symbol
    Gls2provided by MGI
    Official Full Name
    glutaminase 2 (liver, mitochondrial)provided by MGI
    Primary source
    MGI:2143539
    See related
    Ensembl:ENSMUSG00000044005; Vega:OTTMUSG00000033507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GA; GLS; Lga; AI195532; A330074B06Rik
    Location :
    10 D3; 10
    Sequence :
    Chromosome: 10; NC_000076.6 (128194635..128210004)
    See Gls2 in Epigenomics, MapViewer

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene RNA binding motif, single stranded interacting protein 2 Neighboring gene predicted gene 4556 Neighboring gene SPRY domain containing 4 Neighboring gene timeless circadian clock 1 Neighboring gene major intrinsic protein of eye lens fiber

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Mammalian glutaminase Gls2 gene encodes two functional alternative transcripts by a surrogate promoter usage mechanism. Martín-Rufián M, et al. PLoS One, 2012. PMID 22679499.
    2. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Le A, et al. Cell Metab, 2012 Jan 4. PMID 22225880.
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    5. Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Suzuki S, et al. Proc Natl Acad Sci U S A, 2010 Apr 20. PMID 20351271.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented.
      Title: Mammalian glutaminase Gls2 gene encodes two functional alternative transcripts by a surrogate promoter usage mechanism.
    2. Phosphate-activated glutaminase (GLS2) is a p53-inducible regulator of glutamine metabolism and reactive oxygen species
      Title: Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.
    Submit: New GeneRIF Correction

    Markers

    Genotypes

    Homology

    Clone Names

    • KIAA4146

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    glutaminase liver isoform, mitochondrial
    Names
    glutaminase liver isoform, mitochondrial
    L-glutaminase
    L-glutamine amidohydrolase
    liver mitochondrial glutaminase
    NP_001028436.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033264.3 → NP_001028436.2  glutaminase liver isoform, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC135859, AK220231
      Consensus CDS
      CCDS24263.1
      UniProtKB/Swiss-Prot
      Q571F8
      Related
      ENSMUSP00000047376, OTTMUSP00000045406, ENSMUST00000044776, OTTMUST00000084285
      Conserved Domains (3) summary
      cd00204
      Location:490 – 578
      Blast Score: 169
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:177 – 463
      Blast Score: 1227
      Glutaminase; Glutaminase
      pfam13637
      Location:520 – 572
      Blast Score: 133
      Ank_4; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p1 C57BL/6J

      Range
      128194635..128210004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      130589515..130604841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01090055.1 (4547..19873) None
    genomic AC135859.4 (97472..112841) None
    genomic CH466578.1 EDL24545.1 mixed
    mRNA AK039618.1 None C57BL/6J
    mRNA AK139128.1 None C57BL/6J
    mRNA AK165896.1 BAE38445.1
    mRNA AK168761.1 BAE40597.1 C57BL/6J
    mRNA AK220231.1 BAD90156.1
    mRNA BC141115.1 AAI41116.1
    mRNA EU770627.1 None BALB/c
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q571F8.2 GenPept UniProtKB/Swiss-Prot:Q571F8

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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