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    Plk5 polo-like kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 216166, updated on 5-Mar-2013
    Official Symbol
    Plk5provided by MGI
    Official Full Name
    polo-like kinase 5provided by MGI
    Primary source
    MGI:3026984
    See related
    Ensembl:ENSMUSG00000035486; Vega:OTTMUSG00000019121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330514A18Rik
    Location :
    10 C1; 10
    Sequence :
    Chromosome: 10; NC_000076.6 (80356459..80365489)
    See Plk5 in Epigenomics, MapViewer

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 6 Neighboring gene ADAMTS-like 5 Neighboring gene mex3 homolog D (C. elegans) Neighboring gene methyl-CpG binding domain protein 3

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    2. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. de Cárcer G, et al. Mol Cell Biol, 2011 Mar. PMID 21245385.
    3. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Pereira JD, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20798045.
    4. The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. Andrysik Z, et al. Nucleic Acids Res, 2010 May. PMID 20100802.
    5. Genome-wide atlas of gene expression in the adult mouse brain. Lein ES, et al. Nature, 2007 Jan 11. PMID 17151600.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Plk5 is mostly expressed in the brain of both mice and humans, and it modulates the formation of neuritic processes upon stimulation of the brain-derived neurotrophic factor (BDNF)/nerve growth factor (NGF)-Ras pathway in neurons.
      Title: Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.
    2. DNA and protein sequence analyses show that Plk5 shares more similarities with Plk2 and Plk3 than with Plk1 and Plk4.
      Title: The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus.
    Submit: New GeneRIF Correction

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC106082

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT kinase activity IDA
    Inferred from Direct Assay
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G2 DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    defense response to tumor cell IDA
    Inferred from Direct Assay
    more info
    		  
    defense response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		  
    transformed cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    transformed cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    inactive serine/threonine-protein kinase PLK5
    Names
    inactive serine/threonine-protein kinase PLK5
    PLK-5
    serine/threonine-protein kinase PLK5
    NP_898975.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183152.3 → NP_898975.2  inactive serine/threonine-protein kinase PLK5

      Status: VALIDATED

      Source sequence(s)
      AC152062, BB622163, BC086684, BE654673
      Consensus CDS
      CCDS35980.1
      UniProtKB/TrEMBL
      G3X967
      UniProtKB/Swiss-Prot
      Q4FZD7
      Related
      ENSMUSP00000044400, OTTMUSP00000020625, ENSMUST00000039836, OTTMUST00000045801
      Conserved Domains (3) summary
      pfam00659
      Location:424 – 487
      Blast Score: 202
      POLO_box; POLO box duplicated region
      smart00220
      Location:27 – 283
      Blast Score: 741
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09925
      Location:27 – 283
      Blast Score: 594
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p1 C57BL/6J

      Range
      80356459..80365489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      81371338..81380211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01086931.1 (2870..11743) None
    genomic AC152062.6 (77837..77846) None
    genomic CH466553.2 EDL31553.1 mixed
      EDL31554.1 mixed
      EDL31555.1 mixed
    mRNA AK031968.1 BAC27628.1 C57BL/6J
    mRNA BB622163.1 None C57BL/6J
    mRNA BC086684.1 AAH86684.1 C57BL/6
    mRNA BC099679.1 AAH99679.1
    mRNA BE654673.1 None C57BL/6J
    mRNA BG297060.1 None
    mRNA BU505736.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZD7.1 GenPept UniProtKB/Swiss-Prot:Q4FZD7

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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