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Tcl1 T cell lymphoma breakpoint 1 [ Mus musculus (house mouse) ]

Gene ID: 21432, updated on 8-May-2016
Official Symbol
Tcl1provided by MGI
Official Full Name
T cell lymphoma breakpoint 1provided by MGI
Primary source
MGI:MGI:1097166
See related
Ensembl:ENSMUSG00000041359 Vega:OTTMUSG00000042098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcl1a
Orthologs
Location:
12 E; 12 55.28 cM
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (105216753..105222737, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (106454963..106460947, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene T cell leukemia/lymphoma 1B, 3 Neighboring gene T cell leukemia/lymphoma 1B, 4 Neighboring gene Tcl1 upstream neural differentiation associated RNA Neighboring gene predicted gene 2721

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
T-cell leukemia/lymphoma protein 1A
Names
T-cell lymphoma breakpoint 1
TCL-1
oncogene TCL-1
oncogene TCL1
protein p14 TCL1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289468.1NP_001276397.1  T-cell leukemia/lymphoma protein 1A isoform 2

    See identical proteins and their annotated locations for NP_001276397.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a longer and distinct C-terminus.
    Source sequence(s)
    AK149361, DV653827, DV660020
    Consensus CDS
    CCDS70418.1
    UniProtKB/TrEMBL
    Q3UES7
    Related
    ENSMUSP00000098632, OTTMUSP00000061588, ENSMUST00000101071, OTTMUST00000110420
    Conserved Domains (1) summary
    pfam01840
    Location:1102
    TCL1_MTCP1; TCL1/MTCP1 family
  2. NM_001309484.1NP_001296413.1  T-cell leukemia/lymphoma protein 1A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon and contains an alternate internal exon, resulting in the use of an alternate start codon, compared to variant 2. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    CJ087217, DV646075, DV649899, DV653827, DV660020
  3. NM_001309485.1NP_001296414.1  T-cell leukemia/lymphoma protein 1A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in its 3' coding region and contains an alternate internal exon, resulting in a frameshift and an early stop codon, compared to variant 2. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    CA558861, DV646075, DV653827, DV655843, DV660020
    UniProtKB/TrEMBL
    H3BJP6
    Conserved Domains (1) summary
    pfam01840
    Location:180
    TCL1_MTCP1; TCL1/MTCP1 family
  4. NM_009337.3NP_033363.1  T-cell leukemia/lymphoma protein 1A isoform 1

    See identical proteins and their annotated locations for NP_033363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK163387, BC052336, DV653827
    Consensus CDS
    CCDS36549.1
    UniProtKB/Swiss-Prot
    P56280
    Related
    ENSMUSP00000036066, OTTMUSP00000061587, ENSMUST00000041316, OTTMUST00000110419
    Conserved Domains (1) summary
    pfam01840
    Location:1111
    TCL1_MTCP1; TCL1/MTCP1 family

RNA

  1. NR_110339.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CJ087554, DV648028, DV653827, DV660020, DV663230

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    105216753..105222737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000034.1 Alternate Mm_Celera

    Range
    106449260..106455244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)