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Disp2 dispatched RND transporter family member 2 [ Mus musculus (house mouse) ]

Gene ID: 214240, updated on 11-Apr-2024

Summary

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Official Symbol
Disp2provided by MGI
Official Full Name
dispatched RND transporter family member 2provided by MGI
Primary source
MGI:MGI:2388733
See related
Ensembl:ENSMUSG00000040035 AllianceGenome:MGI:2388733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DispB; mKIAA1742; B230210L08Rik
Summary
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. [provided by RefSeq, Sep 2015]
Expression
Biased expression in cerebellum adult (RPKM 51.6), cortex adult (RPKM 28.9) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Disp2 in Genome Data Viewer
Location:
2 E5; 2 59.46 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118610183..118625656)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118779702..118795175)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118588340-118588523 Neighboring gene coiled-coil domain containing 9B Neighboring gene STARR-positive B cell enhancer mm9_chr2:118590344-118590645 Neighboring gene predicted gene, 54146 Neighboring gene proline/histidine/glycine-rich 1 Neighboring gene predicted gene, 38629 Neighboring gene kinetochore-localized astrin/SPAG5 binding Neighboring gene predicted gene, 39913

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Ma Y, et al. Cell, 2002 Oct 4. PMID 12372301
  2. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. Anderson KR, et al. BMC Dev Biol, 2009 Dec 10. PMID 20003319, Free PMC Article
  3. βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function. Arnes L, et al. Genes Dev, 2016 Mar 1. PMID 26944677, Free PMC Article
  4. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dispatched plays a role in hedgehog body patterning, as demonstrated in transgenic mice
    Title: Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
protein dispatched homolog 2
Names
dispatched B
dispatched RND tramsporter family member 2
dispatched homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_170593.3 → NP_733481.1  protein dispatched homolog 2

    See identical proteins and their annotated locations for NP_733481.1

    Status: REVIEWED

    Source sequence(s)
    AL772255
    Consensus CDS
    CCDS16584.1
    UniProtKB/Swiss-Prot
    Q148A2, Q80T98, Q8CBA3, Q8CIP5
    Related
    ENSMUSP00000037136.3, ENSMUST00000037547.9
    Conserved Domains (1) summary
    cl21543
    Location:448 → 598
    MMPL; MMPL family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118610183..118625656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499107.2 → XP_006499170.1  protein dispatched homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006499170.1

    UniProtKB/Swiss-Prot
    Q148A2, Q80T98, Q8CBA3, Q8CIP5
    Conserved Domains (1) summary
    cl21543
    Location:448 → 598
    MMPL; MMPL family

  2. XM_030249308.1 → XP_030105168.1  protein dispatched homolog 2 isoform X2

    Conserved Domains (1) summary
    cl21543
    Location:22 → 172
    MMPL; MMPL family

  3. XM_030249309.1 → XP_030105169.1  protein dispatched homolog 2 isoform X2

    Conserved Domains (1) summary
    cl21543
    Location:22 → 172
    MMPL; MMPL family

  4. XM_017316979.3 → XP_017172468.1  protein dispatched homolog 2 isoform X2

    Conserved Domains (1) summary
    cl21543
    Location:22 → 172
    MMPL; MMPL family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CIP5.1 GenPept UniProtKB/Swiss-Prot:Q8CIP5

Gene LinkOut

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