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Kmt2a lysine (K)-specific methyltransferase 2A [ Mus musculus (house mouse) ]

Gene ID: 214162, updated on 26-Jul-2015
Official Symbol
Kmt2aprovided by MGI
Official Full Name
lysine (K)-specific methyltransferase 2Aprovided by MGI
Primary source
MGI:MGI:96995
See related
Ensembl:ENSMUSG00000002028; Vega:OTTMUSG00000021055
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HRX; Mll; All1; Mll1; ALL-1; Cxxc7; HTRX1; mKIAA4050; 6430520K01
Orthologs
See Kmt2a in Epigenomics, MapViewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
37
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (44803355..44881359, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (44611438..44689357, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 25 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene predicted gene, 30816 Neighboring gene predicted gene, 39326 Neighboring gene predicted gene, 30883 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4050

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase activity (H3-K4 specific) ISO
Inferred from Sequence Orthology
more info
 
histone-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
unmethylated CpG binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K4 dimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K4 methylation ISO
Inferred from Sequence Orthology
more info
 
histone H3-K4 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K4 trimethylation ISO
Inferred from Sequence Orthology
more info
 
histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
 
methylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine monomethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone H3-K4 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transporter activity ISO
Inferred from Sequence Orthology
more info
 
protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of histone H3-K14 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of histone H3-K27 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of histone H3-K4 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of histone H3-K9 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
histone-lysine N-methyltransferase 2A
Names
histone-lysine N-methyltransferase MLL
lysine N-methyltransferase 2A
myeloid/lymphoid or mixed-lineage leukemia 1
myeloid/lymphoid or mixed-lineage leukemia protein 1
trithorax Drosophila
zinc finger protein HRX
NP_001074518.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081049.1NP_001074518.1  histone-lysine N-methyltransferase 2A

    Status: PROVISIONAL

    Source sequence(s)
    AC061963, AC142113
    Consensus CDS
    CCDS40603.1
    UniProtKB/Swiss-Prot
    P55200
    Related
    ENSMUSP00000002095, ENSMUST00000002095
    Conserved Domains (11) summary
    cd05493
    Location:16461776
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:36633746
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:38253945
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:39473963
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:38113963
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:11441191
    zf-CXXC; CXXC zinc finger domain
    pfam05964
    Location:20222072
    FYRN; F/Y-rich N-terminus
    cd15588
    Location:14321478
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:14801529
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:15671623
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:18701982
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    44803355..44881359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242443.1XP_011240745.1  

    Conserved Domains (11) summary
    cd05493
    Location:16481778
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:36653748
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:38273947
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:39493965
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:38133965
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:11441191
    zf-CXXC; CXXC zinc finger domain
    pfam05964
    Location:20242074
    FYRN; F/Y-rich N-terminus
    cd15588
    Location:14321478
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:14801528
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:15661625
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:18721984
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
  2. XM_006510128.1XP_006510191.1  

    Conserved Domains (11) summary
    cd05493
    Location:16461776
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:36633746
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:38253945
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:39473963
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:38113963
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:11441191
    zf-CXXC; CXXC zinc finger domain
    pfam05964
    Location:20222072
    FYRN; F/Y-rich N-terminus
    cd15588
    Location:14321478
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:14801529
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:15671623
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:18701982
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
  3. XM_011242442.1XP_011240744.1  

    Conserved Domains (11) summary
    cd05493
    Location:16491779
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:36653748
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:38273947
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:39493965
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:38133965
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:11441191
    zf-CXXC; CXXC zinc finger domain
    pfam05964
    Location:20242074
    FYRN; F/Y-rich N-terminus
    cd15588
    Location:14321478
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:14801529
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:15671626
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:18721984
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
  4. XM_011242441.1XP_011240743.1  

    Conserved Domains (11) summary
    cd05493
    Location:16491779
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:36663749
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:38283948
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:39503966
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:38143966
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:11441191
    zf-CXXC; CXXC zinc finger domain
    pfam05964
    Location:20252075
    FYRN; F/Y-rich N-terminus
    cd15588
    Location:14321478
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:14801529
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:15671626
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:18731985
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
  5. XM_011242444.1XP_011240746.1  

    Conserved Domains (8) summary
    cd05493
    Location:16491779
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:36663749
    FYRC; FY-rich domain, C-terminal region
    pfam02008
    Location:11441191
    zf-CXXC; CXXC zinc finger domain
    pfam05964
    Location:20252075
    FYRN; F/Y-rich N-terminus
    cd15588
    Location:14321478
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:14801529
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:15671626
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:18731985
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    42068287..42146334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)