Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Tcf7l2provided by MGI
Official Full Name: transcription factor 7 like 2, T cell specific, HMG boxprovided by MGI
Primary source: MGI:1202879
See related: Ensembl:ENSMUSG00000024985; Vega:OTTMUSG00000020410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcf4; TCF4B; TCF4E; Tcf-4; mTcf-4B; mTcf-4E
Annotation information: Note: Tcf4 (GeneID: 21413) and Tcf7l2 (GeneID: 21416) loci share the Tcf4 symbol/alias in common. Tcf4 is a widely used alternative name for T-cell-specific transcription factor 4 (Tcf7l2) conflicting with the official symbol for transcription factor 4 (Tcf4). [26 Jun 2008]

Genomic context

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Location :: 19 D2; 19 51.59 cM

Sequence :: Chromosome: 19; NC_000085.6 (55741810..55933655)

See Tcf7l2 in Epigenomics, MapViewer

Chromosome 19 - NC_000085.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that TCF7L2 and Wnt signaling control gut and brain proglucagon expression and glucose homeostasis; positive cross-talk between Wnt and glucagon-like peptide 1/cAMP signaling appears to regulate brain metabolism.
Title: The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis.
robust TCF7L2 expression was found in the tectal and tegmental structures of the superior and inferior colliculi as well as transient expression in neuroepithelium of the cerebral and hippocampal cortices of E16 and E18.5[review]
Title: Review of the neuroanatomic landscape implicated in glucose sensing and regulation of nutrient signaling: immunophenotypic localization of diabetes gene Tcf7l2 in the developing murine brain.
Selective deletion of Tcf7l2 in the pancreas alters glucose homeostasis in mice carrying TCF7L2 risk alleles, indicating the direct role of this factor in controlling beta cell function.
Title: Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.
A mouse genetics approach shows that removal of TCF4 from beta cells does not affect their function, whereas manipulating TCF4 levels in the liver has major effects on metabolism. In Tcf7l2 double negatice mice, the immediate postnatal surge in liver metabolism does not occur. Consequently, pups die due to hypoglycemia.
Title: Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Data suggest that TCF7L2 and Wnt signaling are negative regulators of gluconeogenesis in hepatocytes; TCF7L2 is among the downstream effectors of insulin in hepatocytes; insulin or feeding stimulates hepatic TCF7L2 expression.
Title: The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis.
these data suggest a crucial role of TCF7L2 in hepatic glucose metabolism; reduced hepatic expression of nuclear isoforms of this factor might be a critical instigator of hyperglycemia in type 2 diabetes
Title: TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver.
During myelin formation, Tcf7l2/beta-catenin is regulated temporally, spatially, and also at levels of expression.
Title: Tcf7l2 is tightly controlled during myelin formation.
The results suggest that decreased expression of Tcf7l2 confers reduction of diabetic susceptibility in mice via regulation on the metabolism of glucose and lipid.
Title: Reduction in Tcf7l2 expression decreases diabetic susceptibility in mice.
Tcf7l2 alters behavior in mice. Importantly, these differences are observed prior to the onset of detectable glucose metabolism abnormalities
Title: Modulation ofTcf7l2 expression alters behavior in mice.
Tcf7l2 plays a role in regulating glucose tolerance, suggesting that overexpression of this gene is associated with increased risk of T2D.
Title: Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.

Submit: New GeneRIF Correction See all (30)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (5) 1 citation
Targeted (knock-out) (2) 1 citation
Targeted (other) (3) 1 citation
Targeted (knock-in) (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:204009	BioGRID:198512	Ctnnb1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression
BioGRID:204009	BioGRID:241423	Hdac1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:204009	BioGRID:200260	Hdac2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:204009	BioGRID:200354	Hnf4a	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Acute myeloid leukemia, organism-specific biosystem (from KEGG)
Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Acute myeloid leukemia, conserved biosystem (from KEGG)
Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Adherens junction, organism-specific biosystem (from KEGG)
Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Adherens junction, conserved biosystem (from KEGG)
Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
Basal cell carcinoma, organism-specific biosystem (from KEGG)
Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
Basal cell carcinoma, conserved biosystem (from KEGG)
Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
Colorectal cancer, organism-specific biosystem (from KEGG)
Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Colorectal cancer, conserved biosystem (from KEGG)
Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Endometrial cancer, organism-specific biosystem (from KEGG)
Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
Endometrial cancer, conserved biosystem (from KEGG)
Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
Hippo signaling pathway, organism-specific biosystem (from KEGG)
Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Hippo signaling pathway, conserved biosystem (from KEGG)
Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem (from REACTOME)
Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Melanogenesis, organism-specific biosystem (from KEGG)
Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
Melanogenesis, conserved biosystem (from KEGG)
Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem (from REACTOME)
Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Thyroid cancer, organism-specific biosystem (from KEGG)
Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
Thyroid cancer, conserved biosystem (from KEGG)
Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

24.MMHAP64FRH9.seq (e-PCR)
- UniSTS:123653

Tcf7l2 (e-PCR), detects polymorphism
- UniSTS:239190

Tcf7l2 (e-PCR), detects polymorphism
- UniSTS:239191

NoName (e-PCR)
- UniSTS:237978

RH142640 (e-PCR)
- UniSTS:231887

Tcf7l2 (e-PCR), detects polymorphism
- UniSTS:507888

Homology

Homologs of the Tcf7l2 gene: The Tcf7l2 gene is conserved in human, Rhesus monkey, rat, chicken, zebrafish, fruit fly, and mosquito.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
RNA polymerase II core promoter proximal region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II repressing transcription factor binding	ISO Inferred from Sequence Orthology more info
armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
beta-catenin binding	ISO Inferred from Sequence Orthology more info
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
gamma-catenin binding	ISO Inferred from Sequence Orthology more info
nuclear hormone receptor binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
transcription factor binding	ISO Inferred from Sequence Orthology more info
transcription regulatory region DNA binding	IBA Inferred from Biological aspect of Ancestor more info
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info
transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
Wnt receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
blood vessel development	ISO Inferred from Sequence Orthology more info
bone mineralization	IGI Inferred from Genetic Interaction more info	PubMed
canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
catenin import into nucleus	IDA Inferred from Direct Assay more info	PubMed
cell cycle arrest	ISO Inferred from Sequence Orthology more info
cell proliferation	ISO Inferred from Sequence Orthology more info
embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
embryonic genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
embryonic hindgut morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
face morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
fat cell differentiation	ISO Inferred from Sequence Orthology more info
glucose homeostasis	ISO Inferred from Sequence Orthology more info
maintenance of DNA repeat elements	ISO Inferred from Sequence Orthology more info
myoblast fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
myoblast fate commitment	ISO Inferred from Sequence Orthology more info
negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of canonical Wnt receptor signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
negative regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
neural tube development	IGI Inferred from Genetic Interaction more info	PubMed
odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
pituitary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
positive regulation of protein kinase B signaling cascade	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of hormone metabolic process	ISO Inferred from Sequence Orthology more info
regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info
regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
secretory granule localization	IMP Inferred from Mutant Phenotype more info	PubMed
skin development	IGI Inferred from Genetic Interaction more info	PubMed
somatic stem cell maintenance	IGI Inferred from Genetic Interaction more info	PubMed
somatic stem cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
beta-catenin-TCF7L2 complex	ISO Inferred from Sequence Orthology more info
catenin-TCF7L2 complex	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
nuclear chromatin	ISO Inferred from Sequence Orthology more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
protein-DNA complex	ISO Inferred from Sequence Orthology more info
transcription factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor 7-like 2

Names: transcription factor 7-like 2; mTCF-4; T-cell factor 4; HMG box transcription factor 4; T-cell-specific transcription factor 4; transcription factor 7-like 2, T-cell specific, HMG-box

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142918.1 → NP_001136390.1 transcription factor 7-like 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC118695, AC137148, AC157916, AJ223070, AW823541

Consensus CDS

CCDS50471.1

UniProtKB/TrEMBL

E9QQ91

UniProtKB/Swiss-Prot

Q924A0

Related

ENSMUSP00000107283, OTTMUSP00000022196, ENSMUST00000111656, OTTMUST00000048432

Conserved Domains (2) summary

cd01388
Location:330 – 397
Blast Score: 276

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 236
Blast Score: 440

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142919.1 → NP_001136391.1 transcription factor 7-like 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks a 17 aa segment near the C-terminus, compared to isoform 1.

Source sequence(s)

AC118695, AC157916, AK038720, AW823541

UniProtKB/TrEMBL

Q8CAI6

Conserved Domains (2) summary

cd01388
Location:330 – 397
Blast Score: 274

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 236
Blast Score: 441

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142920.1 → NP_001136392.1 transcription factor 7-like 2 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) includes an alternate in-frame exon in the 5' coding region, uses two alternate in-frame splice sites in the central coding region, and lacks 4 exons in the 3' coding region, compared to variant 1. The resulting isoform (4) has multiple internal differences and a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC118695, AC137148, AC157916, AK035059, AW823541

Consensus CDS

CCDS50469.1

UniProtKB/TrEMBL

E9Q990

UniProtKB/TrEMBL

Q8BS68

Conserved Domains (2) summary

cd01388
Location:354 – 421
Blast Score: 271

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 125
Blast Score: 298

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142921.1 → NP_001136393.1 transcription factor 7-like 2 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site in the central coding region and lacks 3 exons in the 3' coding region, compared to variant 1. The resulting isoform (5) includes an additional 5 aa segment and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC118695, AC137148, AC157916, AW823541

Consensus CDS

CCDS50470.1

UniProtKB/Swiss-Prot

Q924A0

Conserved Domains (2) summary

cd01388
Location:335 – 402
Blast Score: 273

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 236
Blast Score: 438

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142922.1 → NP_001136394.1 transcription factor 7-like 2 isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting isoform (6) has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC118695, AC137148, AC157916, AW823541

Consensus CDS

CCDS50472.1

UniProtKB/TrEMBL

E9QQ90

Related

ENSMUSP00000107284, ENSMUST00000111657

Conserved Domains (2) summary

cd01388
Location:330 – 397
Blast Score: 277

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 236
Blast Score: 441

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142923.1 → NP_001136395.1 transcription factor 7-like 2 isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks 3 exons in the 3' coding region, compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC118695, AC137148, AC157916, AW823541

Consensus CDS

CCDS50473.1

UniProtKB/TrEMBL

D3YWT3

Related

ENSMUSP00000042950, OTTMUSP00000022202, ENSMUST00000041717, OTTMUST00000048438

Conserved Domains (2) summary

cd01388
Location:330 – 397
Blast Score: 272

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 236
Blast Score: 439

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142924.1 → NP_001136396.1 transcription factor 7-like 2 isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (8) uses an alternate 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (8) has a substantially shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC118695, AK048536, AW823541, CA750374

Consensus CDS

CCDS50474.1

UniProtKB/Swiss-Prot

Q924A0

Related

ENSMUSP00000107273, OTTMUSP00000022197, ENSMUST00000111646, OTTMUST00000048433

Conserved Domains (2) summary

cd01388
Location:170 – 237
Blast Score: 278

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:2 – 76
Blast Score: 189

CTNNB1_binding; N-terminal CTNNB1 binding
NM_009333.3 → NP_033359.2 transcription factor 7-like 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two exons in the 3' coding region, compared to variant 1. The resulting isoform (3) has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC118695, AC157916, AW823541, BC052022

Consensus CDS

CCDS29911.1

UniProtKB/TrEMBL

Q80WT9

Related

ENSMUSP00000050081, ENSMUST00000061496

Conserved Domains (2) summary

cd01388
Location:330 – 397
Blast Score: 274

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 236
Blast Score: 438

CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000085.6 Reference GRCm38.p1 C57BL/6J

Range

55741810..55933655

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000041.1 Alternate Mm_Celera

Range

57933629..58125906

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GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01144574.1 (45250..46121)	None
genomic	AAHY01144575.1	None
genomic	AAHY01144576.1	None
genomic	AAHY01144577.1	None
genomic	AAHY01144578.1	None
genomic	AAHY01144579.1	None
genomic	AAHY01144580.1	None
genomic	AAHY01144581.1	None
genomic	AAHY01144582.1	None
genomic	AAHY01144583.1	None
genomic	AAHY01144584.1	None
genomic	AC118695.10 (178113..180304)	None
genomic	AC137148.14 (3928..112213)	None
genomic	AC157916.2 (116472..117859)	None
genomic	AF363722.1	None	C57BL/6J
genomic	CH466585.1	EDL01739.1	mixed
		EDL01740.1	mixed
		EDL01741.1	mixed
		EDL01742.1	mixed
		EDL01743.1	mixed
		EDL01744.1	mixed
mRNA	AF107298.1	AAD16967.1	ICR
mRNA	AF107299.1	AAD16968.1	ICR
mRNA	AF363724.1	AAK77488.1	CD-1
mRNA	AF363725.1	AAK77489.1	CD-1
mRNA	AF363726.1	AAK77490.1	CD-1
mRNA	AJ223070.1	CAA11071.1	C57BL/6
mRNA	AK018098.1	None	C57BL/6J
mRNA	AK035059.1	BAC28929.1	C57BL/6J
mRNA	AK038720.1	BAC30109.1	C57BL/6J
mRNA	AK048536.1	BAC33366.1	C57BL/6J
mRNA	AK052583.1	None	C57BL/6J
mRNA	AK084488.1	BAC39196.1	C57BL/6J
mRNA	AK132465.1	BAE21182.1	C57BL/6J
mRNA	AK163011.1	None	C57BL/6J
mRNA	AW823541.1	None
mRNA	AY072035.1	AAL58534.1
mRNA	BC009807.1	None	FVB/N
mRNA	BC011397.1	None	FVB/N
mRNA	BC052022.1	AAH52022.1	C57BL/6
mRNA	CA750374.1	None	C57BL/6