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Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box [ Mus musculus (house mouse) ]

Gene ID: 21416, updated on 21-Oct-2014
Official Symbol
Tcf7l2provided by MGI
Official Full Name
transcription factor 7 like 2, T cell specific, HMG boxprovided by MGI
Primary source
MGI:MGI:1202879
See related
Ensembl:ENSMUSG00000024985; Vega:OTTMUSG00000020410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcf4; TCF4B; TCF4E; Tcf-4; mTcf-4B; mTcf-4E
Annotation information
Note: Tcf4 (GeneID: 21413) and Tcf7l2 (GeneID: 21416) loci share the Tcf4 symbol/alias in common. Tcf4 is a widely used alternative name for T-cell-specific transcription factor 4 (Tcf7l2) conflicting with the official symbol for transcription factor 4 (Tcf4). [26 Jun 2008]
See Tcf7l2 in Epigenomics, MapViewer
Location:
19 D2; 19 51.59 cM
Exon count:
29
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 19 NC_000085.6 (55741810..55933659)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930552P12 gene Neighboring gene uncharacterized LOC102634055 Neighboring gene uncharacterized LOC102634217 Neighboring gene uncharacterized LOC102634291

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
RNA polymerase II repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IGI
Inferred from Genetic Interaction
more info
 
gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
nuclear hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
blood vessel development ISO
Inferred from Sequence Orthology
more info
 
bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
catenin import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 
embryonic digestive tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic genitalia morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic hindgut morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
face morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 
glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 
insulin metabolic process IMP
Inferred from Mutant Phenotype
more info
 
maintenance of DNA repeat elements ISO
Inferred from Sequence Orthology
more info
 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 
myoblast fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
myoblast fate commitment ISO
Inferred from Sequence Orthology
more info
 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neural tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
regulation of hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 
regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
secretory granule localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin development IGI
Inferred from Genetic Interaction
more info
PubMed 
somatic stem cell maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
somatic stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
beta-catenin-TCF7L2 complex ISO
Inferred from Sequence Orthology
more info
 
catenin-TCF7L2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription factor 7-like 2
Names
transcription factor 7-like 2
mTCF-4
T-cell factor 4
HMG box transcription factor 4
T-cell-specific transcription factor 4
transcription factor 7-like 2, T-cell specific, HMG-box

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142918.1NP_001136390.1  transcription factor 7-like 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC118695, AC137148, AC157916, AJ223070, AW823541
    Consensus CDS
    CCDS50471.1
    UniProtKB/TrEMBL
    E9QQ91
    UniProtKB/Swiss-Prot
    Q924A0
    Related
    ENSMUSP00000107283, OTTMUSP00000022196, ENSMUST00000111656, OTTMUST00000048432
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. NM_001142919.1NP_001136391.1  transcription factor 7-like 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks a 17 aa segment near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AC118695, AC157916, AK038720, AW823541
    UniProtKB/TrEMBL
    Q8CAI6
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. NM_001142920.1NP_001136392.1  transcription factor 7-like 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate in-frame exon in the 5' coding region, uses two alternate in-frame splice sites in the central coding region, and lacks 4 exons in the 3' coding region, compared to variant 1. The resulting isoform (4) has multiple internal differences and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC118695, AC137148, AC157916, AK035059, AW823541
    Consensus CDS
    CCDS50469.1
    UniProtKB/TrEMBL
    E9Q990
    UniProtKB/TrEMBL
    Q8BS68
    Conserved Domains (2) summary
    cd01388
    Location:354421
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. NM_001142921.1NP_001136393.1  transcription factor 7-like 2 isoform 5

    See proteins identical to NP_001136393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the central coding region and lacks 3 exons in the 3' coding region, compared to variant 1. The resulting isoform (5) includes an additional 5 aa segment and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC118695, AC137148, AC157916, AW823541
    Consensus CDS
    CCDS50470.1
    UniProtKB/Swiss-Prot
    Q924A0
    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. NM_001142922.1NP_001136394.1  transcription factor 7-like 2 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting isoform (6) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC118695, AC137148, AC157916, AW823541
    Consensus CDS
    CCDS50472.1
    UniProtKB/TrEMBL
    E9QQ90
    Related
    ENSMUSP00000107284, ENSMUST00000111657
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. NM_001142923.1NP_001136395.1  transcription factor 7-like 2 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks 3 exons in the 3' coding region, compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC118695, AC137148, AC157916, AW823541
    Consensus CDS
    CCDS50473.1
    UniProtKB/TrEMBL
    D3YWT3
    Related
    ENSMUSP00000042950, OTTMUSP00000022202, ENSMUST00000041717, OTTMUST00000048438
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. NM_001142924.1NP_001136396.1  transcription factor 7-like 2 isoform 8

    See proteins identical to NP_001136396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (8) has a substantially shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC118695, AK048536, AW823541, CA750374
    Consensus CDS
    CCDS50474.1
    UniProtKB/Swiss-Prot
    Q924A0
    Related
    ENSMUSP00000107273, OTTMUSP00000022197, ENSMUST00000111646, OTTMUST00000048433
    Conserved Domains (3) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam03153
    Location:6149
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  8. NM_009333.3NP_033359.2  transcription factor 7-like 2 isoform 3

    See proteins identical to NP_033359.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons in the 3' coding region, compared to variant 1. The resulting isoform (3) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC118695, AC157916, AW823541, BC052022
    Consensus CDS
    CCDS29911.1
    UniProtKB/TrEMBL
    Q80WT9
    Related
    ENSMUSP00000050081, ENSMUST00000061496
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000085.6 

    Range
    55741810..55933659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526874.1XP_006526937.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. XM_006526861.1XP_006526924.1  

    Conserved Domains (2) summary
    cd01388
    Location:354421
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. XM_006526863.1XP_006526926.1  

    Conserved Domains (2) summary
    cd01388
    Location:349416
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. XM_006526859.1XP_006526922.1  

    Conserved Domains (2) summary
    cd01388
    Location:383450
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1284
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. XM_006526866.1XP_006526929.1  

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. XM_006526868.1XP_006526931.1  

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. XM_006526869.1XP_006526932.1  

    Related
    ENSMUSP00000107291, ENSMUST00000111662
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  8. XM_006526870.1XP_006526933.1  

    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  9. XM_006526876.1XP_006526939.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  10. XM_006526873.1XP_006526936.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  11. XM_006526875.1XP_006526938.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  12. XM_006526877.1XP_006526940.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  13. XM_006526879.1XP_006526942.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  14. XM_006526878.1XP_006526941.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  15. XM_006526888.1XP_006526951.1  

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  16. XM_006526890.1XP_006526953.1  

    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  17. XM_006526880.1XP_006526943.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  18. XM_006526886.1XP_006526949.1  

    Conserved Domains (2) summary
    cd01388
    Location:358425
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  19. XM_006526889.1XP_006526952.1  

    Conserved Domains (2) summary
    cd01388
    Location:349416
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  20. XM_006526883.1XP_006526946.1  

    Conserved Domains (2) summary
    cd01388
    Location:377444
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1283
    CTNNB1_binding; N-terminal CTNNB1 binding
  21. XM_006526898.1XP_006526961.1  

    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  22. XM_006526871.1XP_006526934.1  

    See proteins identical to XP_006526934.1

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  23. XM_006526872.1XP_006526935.1  

    See proteins identical to XP_006526935.1

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  24. XM_006526867.1XP_006526930.1  

    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    CTNNB1_binding; N-terminal CTNNB1 binding
  25. XM_006526855.1XP_006526918.1  

    Conserved Domains (2) summary
    cd01388
    Location:402469
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  26. XM_006526885.1XP_006526948.1  

    Conserved Domains (3) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam03153
    Location:176332
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  27. XM_006526887.1XP_006526950.1  

    Conserved Domains (3) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam03153
    Location:176332
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  28. XM_006526853.1XP_006526916.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  29. XM_006526857.1XP_006526920.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  30. XM_006526858.1XP_006526921.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  31. XM_006526854.1XP_006526917.1  

    Conserved Domains (2) summary
    cd01388
    Location:405472
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1306
    CTNNB1_binding; N-terminal CTNNB1 binding
  32. XM_006526856.1XP_006526919.1  

    Conserved Domains (2) summary
    cd01388
    Location:401468
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    CTNNB1_binding; N-terminal CTNNB1 binding
  33. XM_006526860.1XP_006526923.1  

    Conserved Domains (2) summary
    cd01388
    Location:358425
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  34. XM_006526864.1XP_006526927.1  

    Conserved Domains (2) summary
    cd01388
    Location:358425
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  35. XM_006526862.1XP_006526925.1  

    Conserved Domains (2) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  36. XM_006526865.1XP_006526928.1  

    Conserved Domains (2) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    CTNNB1_binding; N-terminal CTNNB1 binding
  37. XM_006526899.1XP_006526962.1  

    Conserved Domains (2) summary
    cd01388
    Location:253320
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:75154
    CTNNB1_binding; N-terminal CTNNB1 binding
  38. XM_006526893.1XP_006526956.1  

    Conserved Domains (2) summary
    cd01388
    Location:176243
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:277
    CTNNB1_binding; N-terminal CTNNB1 binding
  39. XM_006526892.1XP_006526955.1  

    Conserved Domains (2) summary
    cd01388
    Location:184251
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:785
    CTNNB1_binding; N-terminal CTNNB1 binding
  40. XM_006526895.1XP_006526958.1  

    See proteins identical to XP_006526958.1

    Conserved Domains (2) summary
    cd01388
    Location:175242
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  41. XM_006526897.1XP_006526960.1  

    Conserved Domains (2) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  42. XM_006526894.1XP_006526957.1  

    See proteins identical to XP_006526957.1

    Conserved Domains (2) summary
    cd01388
    Location:175242
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  43. XM_006526901.1XP_006526964.1  

    See proteins identical to XP_006526964.1

    Conserved Domains (1) summary
    cd01388
    Location:69136
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  44. XM_006526891.1XP_006526954.1  

    Conserved Domains (2) summary
    cd01388
    Location:187254
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1088
    CTNNB1_binding; N-terminal CTNNB1 binding
  45. XM_006526881.1XP_006526944.1  

    Conserved Domains (2) summary
    cd01388
    Location:228295
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:55129
    CTNNB1_binding; N-terminal CTNNB1 binding
  46. XM_006526882.1XP_006526945.1  

    Conserved Domains (2) summary
    cd01388
    Location:223290
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:55129
    CTNNB1_binding; N-terminal CTNNB1 binding
  47. XM_006526884.1XP_006526947.1  

    Conserved Domains (2) summary
    cd01388
    Location:219286
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:55129
    CTNNB1_binding; N-terminal CTNNB1 binding
  48. XM_006526900.1XP_006526963.1  

    See proteins identical to XP_006526963.1

    Conserved Domains (1) summary
    cd01388
    Location:69136
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  49. XM_006526896.1XP_006526959.1  

    See proteins identical to XP_006526959.1

    Conserved Domains (2) summary
    cd01388
    Location:175242
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding

RNA

  1. XR_386454.1 RNA Sequence

  2. XR_386455.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000041.1 

    Range
    57933629..58125906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)