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Tcf4 transcription factor 4 [ Mus musculus (house mouse) ]

Gene ID: 21413, updated on 19-Sep-2014
Official Symbol
Tcf4provided by MGI
Official Full Name
transcription factor 4provided by MGI
Primary source
MGI:MGI:98506
See related
Ensembl:ENSMUSG00000053477; Vega:OTTMUSG00000021071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ME2; TFE; E2-2; E2.2; ITF2; SEF2; ITF-2; SEF-2; Tcf-4; ASP-I2; ITF-2b; SEF2-1; MITF-2A; MITF-2B; bHLHb19; 5730422P05Rik
Annotation information
Note: Tcf4 (GeneID: 21413) and Tcf7l2 (GeneID: 21416) loci share the Tcf4 symbol/alias in common. Tcf4 is a widely used alternative name for T-cell-specific transcription factor 4 (Tcf7l2) conflicting with the official symbol for transcription factor 4 (Tcf4). [26 Jun 2008]
See Tcf4 in Epigenomics, MapViewer
Location:
18 E2; 18
Exon count:
30
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 18 NC_000084.6 (69344492..69687967)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730085E03 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC102633669 Neighboring gene uncharacterized LOC102633751 Neighboring gene uncharacterized LOC102633834

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
TFIIB-class binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
TFIIB-class transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding RNA polymerase recruiting transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription factor 4
Names
transcription factor 4
MITF-2
SL3-3 enhancer factor 2
immunoglobulin transcription factor 2
immunoglobulin transcription factor-2
class A helix-loop-helix transcription factor ME2
Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083967.1NP_001077436.1  transcription factor 4 isoform b

    See proteins identical to NP_001077436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform b).
    Source sequence(s)
    AK039181, AK047926, AK081012, BC043050, BY770794, CB247941
    Consensus CDS
    CCDS50315.1
    UniProtKB/Swiss-Prot
    Q60722
    Conserved Domains (1) summary
    cd00083
    Location:561621
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. NM_013685.2NP_038713.1  transcription factor 4 isoform a

    See proteins identical to NP_038713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AK039181, AK047926, AK051958, BC043050, CB247941, U16322
    Consensus CDS
    CCDS29329.1
    UniProtKB/Swiss-Prot
    Q60722
    UniProtKB/TrEMBL
    Q8BPX7
    Related
    ENSMUSP00000110636, OTTMUSP00000023158, ENSMUST00000114985, OTTMUST00000049842
    Conserved Domains (1) summary
    cd00083
    Location:565625
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000084.6 

    Range
    69344492..69687967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525753.1XP_006525816.1  

    Conserved Domains (1) summary
    cd00083
    Location:541601
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. XM_006525747.1XP_006525810.1  

    See proteins identical to XP_006525810.1

    UniProtKB/Swiss-Prot
    Q60722
    Related
    ENSMUSP00000077577, ENSMUST00000078486
    Conserved Domains (1) summary
    cd00083
    Location:565625
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  3. XM_006525749.1XP_006525812.1  

    Conserved Domains (1) summary
    cd00083
    Location:564624
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  4. XM_006525752.1XP_006525815.1  

    Conserved Domains (1) summary
    cd00083
    Location:560620
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  5. XM_006525746.1XP_006525809.1  

    See proteins identical to XP_006525809.1

    UniProtKB/Swiss-Prot
    Q60722
    Conserved Domains (1) summary
    cd00083
    Location:565625
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  6. XM_006525750.1XP_006525813.1  

    See proteins identical to XP_006525813.1

    UniProtKB/Swiss-Prot
    Q60722
    Conserved Domains (1) summary
    cd00083
    Location:561621
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  7. XM_006525748.1XP_006525811.1  

    Conserved Domains (1) summary
    cd00083
    Location:564624
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  8. XM_006525751.1XP_006525814.1  

    Conserved Domains (1) summary
    cd00083
    Location:560620
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  9. XM_006525754.1XP_006525817.1  

    Conserved Domains (1) summary
    cd00083
    Location:489549
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  10. XM_006525765.1XP_006525828.1  

    See proteins identical to XP_006525828.1

    Conserved Domains (1) summary
    cd00083
    Location:436496
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  11. XM_006525759.1XP_006525822.1  

    See proteins identical to XP_006525822.1

    Conserved Domains (1) summary
    cd00083
    Location:436496
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  12. XM_006525755.1XP_006525818.1  

    Conserved Domains (1) summary
    cd00083
    Location:448508
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  13. XM_006525756.1XP_006525819.1  

    Conserved Domains (1) summary
    cd00083
    Location:447507
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  14. XM_006525758.1XP_006525821.1  

    See proteins identical to XP_006525821.1

    Conserved Domains (1) summary
    cd00083
    Location:436496
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  15. XM_006525757.1XP_006525820.1  

    See proteins identical to XP_006525820.1

    Conserved Domains (1) summary
    cd00083
    Location:436496
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  16. XM_006525766.1XP_006525829.1  

    Conserved Domains (1) summary
    cd00083
    Location:405465
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  17. XM_006525760.1XP_006525823.1  

    See proteins identical to XP_006525823.1

    UniProtKB/TrEMBL
    Q91XK1
    Conserved Domains (1) summary
    cd00083
    Location:406466
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  18. XM_006525762.1XP_006525825.1  

    See proteins identical to XP_006525825.1

    UniProtKB/Swiss-Prot
    Q60722
    UniProtKB/TrEMBL
    Q91YV0
    Conserved Domains (1) summary
    cd00083
    Location:402462
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  19. XM_006525764.1XP_006525827.1  

    Conserved Domains (1) summary
    cd00083
    Location:350410
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  20. XM_006525761.1XP_006525824.1  

    Conserved Domains (1) summary
    cd00083
    Location:406466
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  21. XM_006525763.1XP_006525826.1  

    Conserved Domains (1) summary
    cd00083
    Location:402462
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Alternate Mm_Celera

Genomic

  1. AC_000040.1 

    Range
    70630746..70974890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)