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Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [ Mus musculus (house mouse) ]

Gene ID: 213990, updated on 28-May-2016
Official Symbol
Agap3provided by MGI
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3provided by MGI
Primary source
MGI:MGI:2183446
See related
Ensembl:ENSMUSG00000023353 Vega:OTTMUSG00000053658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crag; Crag.; AGAP-3; Centg3; MRIP-1; cnt-g3; AV028425
Orthologs
Location:
5; 5 A3
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (24452177..24502047)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (23957995..24007865)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene Fas-activated serine/threonine kinase Neighboring gene transmembrane and ubiquitin-like domain containing 1 Neighboring gene gastrulation brain homeobox 1 Neighboring gene ankyrin repeat and SOCS box-containing 10

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC37541

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
polyubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
PML body organization ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to UV ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body ISO
Inferred from Sequence Orthology
more info
PubMed 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
Names
CRAM-associated GTPase
MR1-interacting protein
centaurin, gamma 3
centaurin-gamma-3
spidin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256431.1NP_001243360.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC120353
    Conserved Domains (2) summary
    cd04103
    Location:127284
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    pfam00071
    Location:128284
    Ras; Ras family
  2. NM_139153.2NP_631892.2  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_631892.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC120353, AK079516, AV241066, BM943676, BM943884, CJ052480, CJ053222
    Consensus CDS
    CCDS19122.1
    UniProtKB/TrEMBL
    F8VQE9, Q8BV81
    Related
    ENSMUSP00000024123, OTTMUSP00000071009, ENSMUST00000024123, OTTMUST00000133661
    Conserved Domains (6) summary
    cd04103
    Location:127284
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd00204
    Location:788877
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:400644
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00071
    Location:128284
    Ras; Ras family
    pfam01412
    Location:663776
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:788878
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    24452177..24502047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535676.2XP_006535739.1  

    UniProtKB/TrEMBL
    A0A0G2JDW1
    Related
    ENSMUSP00000142529, OTTMUSP00000071010, ENSMUST00000199856, OTTMUST00000133663
    Conserved Domains (2) summary
    cd04103
    Location:310467
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    pfam00071
    Location:311467
    Ras; Ras family
  2. XM_006535673.2XP_006535736.1  

    Conserved Domains (6) summary
    cd04103
    Location:310467
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd00204
    Location:9711060
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:583827
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00071
    Location:311467
    Ras; Ras family
    pfam01412
    Location:846959
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:9711061
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_006535674.2XP_006535737.1  

    Conserved Domains (6) summary
    cd04103
    Location:310467
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd00204
    Location:9251014
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:583781
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00071
    Location:311467
    Ras; Ras family
    pfam01412
    Location:800913
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:9251015
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_006535675.2XP_006535738.1  

    Conserved Domains (6) summary
    cd04103
    Location:310467
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd00204
    Location:868957
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:583724
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00071
    Location:311467
    Ras; Ras family
    pfam01412
    Location:743856
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:868958
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_006535677.2XP_006535740.1  

    Conserved Domains (4) summary
    cd00204
    Location:443532
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:55299
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam01412
    Location:318431
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:443533
    Ank_2; Ankyrin repeats (3 copies)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    21394522..21452021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)