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Tbx3 T-box 3 [ Mus musculus (house mouse) ]

Gene ID: 21386, updated on 26-Aug-2014
Official Symbol
Tbx3provided by MGI
Official Full Name
T-box 3provided by MGI
Primary source
MGI:98495
See related
Ensembl:ENSMUSG00000018604; Vega:OTTMUSG00000029655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D5Ertd189e
See Tbx3 in Epigenomics, MapViewer
Location:
5 F; 5 60.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 5 NC_000071.6 (119670162..119684724)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene expressed sequence AW549542 Neighboring gene T-box 3, opposite strand 1 Neighboring gene predicted gene 16063 Neighboring gene T-box 3, opposite strand 2 Neighboring gene predicted gene 5563 Neighboring gene T-box 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior axis specification, embryo ISO
Inferred from Sequence Orthology
more info
 
atrioventricular bundle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell aging IDA
Inferred from Direct Assay
more info
PubMed 
cell aging ISO
Inferred from Sequence Orthology
more info
 
cellular senescence ISO
Inferred from Sequence Orthology
more info
 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
female genitalia development ISO
Inferred from Sequence Orthology
more info
 
follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
limbic system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
 
male genitalia development ISO
Inferred from Sequence Orthology
more info
 
mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland development ISO
Inferred from Sequence Orthology
more info
 
mammary placode formation IDA
Inferred from Direct Assay
more info
PubMed 
mammary placode formation IGI
Inferred from Genetic Interaction
more info
PubMed 
mesoderm morphogenesis ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
organ morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
palate development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
sinoatrial node cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development ISO
Inferred from Sequence Orthology
more info
 
specification of organ position IDA
Inferred from Direct Assay
more info
PubMed 
stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
T-box transcription factor TBX3
Names
T-box transcription factor TBX3
T-box protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011535.3NP_035665.2  T-box transcription factor TBX3 isoform 1

    See proteins identical to NP_035665.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA543734, AK052453, AK145436, BB054411, BB694449, BB728182, CJ216213
    Consensus CDS
    CCDS19613.1
    UniProtKB/Swiss-Prot
    P70324
    UniProtKB/TrEMBL
    Q3ULL3
    Related
    ENSMUSP00000018748, OTTMUSP00000038109, ENSMUST00000018748, OTTMUST00000073569
    Conserved Domains (2) summary
    pfam12598
    Location:323411
    Blast Score: 287
    TBX; T-box transcription factor
    cd00182
    Location:102307
    Blast Score: 928
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  2. NM_198052.2NP_932169.1  T-box transcription factor TBX3 isoform 2

    See proteins identical to NP_932169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AA543734, BB054411, BB694449, BB728182, BC096551, CJ216213
    Consensus CDS
    CCDS19614.1
    UniProtKB/TrEMBL
    Q4VA43
    Related
    ENSMUSP00000112519, OTTMUSP00000038110, ENSMUST00000121021, OTTMUST00000073570
    Conserved Domains (2) summary
    pfam12598
    Location:303391
    Blast Score: 286
    TBX; T-box transcription factor
    cd00182
    Location:102287
    Blast Score: 959
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000071.6 

    Range
    119670162..119684724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530276.1XP_006530339.1  

    See proteins identical to XP_006530339.1

    UniProtKB/Swiss-Prot
    P70324
    Conserved Domains (2) summary
    pfam12598
    Location:323411
    Blast Score: 287
    TBX; T-box transcription factor
    cd00182
    Location:102307
    Blast Score: 928
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  2. XM_006530277.1XP_006530340.1  

    See proteins identical to XP_006530340.1

    UniProtKB/TrEMBL
    Q4VA43
    Related
    ENSMUSP00000078657, ENSMUST00000079719
    Conserved Domains (2) summary
    pfam12598
    Location:303391
    Blast Score: 286
    TBX; T-box transcription factor
    cd00182
    Location:102287
    Blast Score: 959
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

Alternate Mm_Celera

Genomic

  1. AC_000027.1 

    Range
    116764912..116778809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)