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Xist inactive X specific transcripts [ Mus musculus (house mouse) ]

Gene ID: 213742, updated on 29-May-2016
Official Symbol
Xistprovided by MGI
Official Full Name
inactive X specific transcriptsprovided by MGI
Primary source
MGI:MGI:98974
See related
Ensembl:ENSMUSG00000086503
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI314753; A430022B11
Summary
X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome. It is essential for the initiation and spread of X-inactivation. It silences hundreds of genes by recruiting and tethering repressive chromatin-modifying complexes to the inactive X chromosome. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
Orthologs
Location:
X D; X 46.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (103460373..103483233, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (100655712..100678572, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene cysteine-rich hydrophobic domain 1 Neighboring gene testis specific X-linked gene Neighboring gene X (inactive)-specific transcript, opposite strand Neighboring gene ribosomal protein S12, pseudogene 1 Neighboring gene 40S ribosomal protein S19-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
X chromosome IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_001463.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL669964
    Related
    ENSMUST00000127786
  2. NR_001570.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced in the 3' end and is shorter compared to variant 1.
    Source sequence(s)
    AL669964

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    103460373..103483233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    90362213..90385056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)