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Pth2r parathyroid hormone 2 receptor [ Mus musculus (house mouse) ]

Gene ID: 213527, updated on 11-Apr-2024

Summary

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Official Symbol
Pth2rprovided by MGI
Official Full Name
parathyroid hormone 2 receptorprovided by MGI
Primary source
MGI:MGI:2180917
See related
Ensembl:ENSMUSG00000025946 AllianceGenome:MGI:2180917
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pthr2
Summary
Predicted to enable G protein-coupled peptide receptor activity; parathyroid hormone receptor activity; and peptide hormone binding activity. Involved in positive regulation of cold-induced thermogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human PTH2R (parathyroid hormone 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
1 C3; 1 33.05 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65317921..65428784)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65280282..65389625)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65224921-65225030 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65225772-65225881 Neighboring gene STARR-positive B cell enhancer ABC_E5765 Neighboring gene isocitrate dehydrogenase 1 (NADP+), soluble Neighboring gene phosphoinositide kinase, FYVE type zinc finger containing Neighboring gene STARR-positive B cell enhancer ABC_E5766 Neighboring gene STARR-seq mESC enhancer starr_01177 Neighboring gene STARR-seq mESC enhancer starr_01178 Neighboring gene STARR-seq mESC enhancer starr_01179 Neighboring gene predicted gene 28926 Neighboring gene predicted gene 28923

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The parathyroid hormone 2 receptor participates in physiological and behavioral alterations of mother mice. Gellén B, et al. Physiol Behav, 2017 Nov 1. PMID 28890271
  2. Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala. Tsuda MC, et al. J Neurosci, 2015 Sep 2. PMID 26338326, Free PMC Article
  3. Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor. Panda DK, et al. Am J Physiol Endocrinol Metab, 2012 Dec 15. PMID 23092913, Free PMC Article
  4. Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release. Atchison DK, et al. Am J Physiol Renal Physiol, 2012 Oct 15. PMID 22896038, Free PMC Article
  5. Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development. Coutellier L, et al. J Neuroendocrinol, 2011 Jul. PMID 21535248, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that The parathyroid hormone 2 receptor participates in physiological and behavioral alterations of mother mice.
    Title: The parathyroid hormone 2 receptor participates in physiological and behavioral alterations of mother mice.
  2. Data indicate that the nociceptive phenotype of TIP39-knockout {KO) mice was similar to the PTH2R-KO.
    Title: Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues.
  3. Data suggest a role for Pth2r signaling in postnatal growth plate development and subsequent bone mass acquisition.
    Title: Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor.
  4. Involvement of the TIP39/PTH2-R system in the pathways involved in the successful development of the pups.
    Title: Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development.
  5. We propose that TIP39 is an endogenous ligand of the PTH2R and that they form a neuromodulator system, which is optimally positioned to regulate limbic, endocrine, and auditory brain functions.
    Title: Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables parathyroid hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables parathyroid hormone receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
parathyroid hormone 2 receptor
Names
PTH2 receptor
parathyroid hormone receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139270.2 → NP_644676.1  parathyroid hormone 2 receptor precursor

    See identical proteins and their annotated locations for NP_644676.1

    Status: PROVISIONAL

    Source sequence(s)
    AK045576
    Consensus CDS
    CCDS15017.1
    UniProtKB/Swiss-Prot
    Q91V95
    Related
    ENSMUSP00000027083.7, ENSMUST00000027083.7
    Conserved Domains (2) summary
    pfam00002
    Location:139 → 406
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:63 → 125
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    65317921..65428784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238473.2 → XP_011236775.1  parathyroid hormone 2 receptor isoform X1

    Conserved Domains (3) summary
    cd14964
    Location:136 → 161
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02793
    Location:58 → 120
    HRM; Hormone receptor domain
    cl28897
    Location:134 → 422
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_011238474.4 → XP_011236776.1  parathyroid hormone 2 receptor isoform X2

    See identical proteins and their annotated locations for XP_011236776.1

    Conserved Domains (3) summary
    cd14964
    Location:100 → 125
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02793
    Location:22 → 84
    HRM; Hormone receptor domain
    cl28897
    Location:98 → 386
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_017319688.2 → XP_017175177.1  parathyroid hormone 2 receptor isoform X5

    Conserved Domains (3) summary
    cd14964
    Location:141 → 166
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02793
    Location:63 → 125
    HRM; Hormone receptor domain
    cl28897
    Location:139 → 324
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_006495842.2 → XP_006495905.1  parathyroid hormone 2 receptor isoform X2

    See identical proteins and their annotated locations for XP_006495905.1

    Conserved Domains (3) summary
    cd14964
    Location:100 → 125
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02793
    Location:22 → 84
    HRM; Hormone receptor domain
    cl28897
    Location:98 → 386
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_017319687.1 → XP_017175176.1  parathyroid hormone 2 receptor isoform X3

    Conserved Domains (3) summary
    cd14964
    Location:86 → 111
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02793
    Location:8 → 70
    HRM; Hormone receptor domain
    cl28897
    Location:84 → 372
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. XM_006495843.4 → XP_006495906.1  parathyroid hormone 2 receptor isoform X4

    Conserved Domains (3) summary
    cd14964
    Location:61 → 86
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02793
    Location:1 → 45
    HRM; Hormone receptor domain
    cl28897
    Location:59 → 347
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91V95.1 GenPept UniProtKB/Swiss-Prot:Q91V95

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