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Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 [ Mus musculus (house mouse) ]

Gene ID: 213498, updated on 8-May-2016
Official Symbol
Arhgef11provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 11provided by MGI
Primary source
MGI:MGI:2441869
See related
Ensembl:ENSMUSG00000041977 Vega:OTTMUSG00000031939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prg; RhoGEF; mKIAA0380; B930073M02; E130307F09; PDZ-RhoGEF
Orthologs
Location:
3; 3 F1
Exon count:
43
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (87617548..87738034)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (87422673..87541955)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ets variant 3 Neighboring gene ets variant 3-like Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene 6570 Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene neurotrophic tyrosine kinase, receptor, type 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • KIAA0380, MGC90827

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
rho guanine nucleotide exchange factor 11

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003912.1NP_001003912.1  rho guanine nucleotide exchange factor 11

    See identical proteins and their annotated locations for NP_001003912.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079565
    Consensus CDS
    CCDS38472.1
    UniProtKB/TrEMBL
    Q68FM7
    Related
    ENSMUSP00000039900, OTTMUSP00000042231, ENSMUST00000039476, OTTMUST00000079227
    Conserved Domains (5) summary
    cd08753
    Location:330474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61137
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:765951
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:46120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9691111
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    87617548..87738034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501264.2XP_006501327.1  

    Conserved Domains (5) summary
    cd08753
    Location:346490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:792978
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9961138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  2. XM_006501272.2XP_006501335.1  

    Conserved Domains (5) summary
    cd08753
    Location:346490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:792978
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9961138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  3. XM_006501267.2XP_006501330.1  

    Conserved Domains (5) summary
    cd08753
    Location:346490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:782968
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9861128
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  4. XM_006501265.2XP_006501328.1  

    Conserved Domains (5) summary
    cd08753
    Location:346490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:791977
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9951137
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  5. XM_006501268.2XP_006501331.1  

    Conserved Domains (5) summary
    cd08753
    Location:346490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:781967
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9851127
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  6. XM_006501273.2XP_006501336.1  

    Conserved Domains (5) summary
    cd08753
    Location:300444
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:746932
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9501092
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  7. XM_006501270.2XP_006501333.1  

    Conserved Domains (5) summary
    cd08753
    Location:306450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:752938
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9561098
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  8. XM_006501274.2XP_006501337.1  

    Conserved Domains (5) summary
    cd08753
    Location:306450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:742928
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9461088
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  9. XM_006501271.2XP_006501334.1  

    Conserved Domains (5) summary
    cd08753
    Location:306450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:751937
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9551097
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  10. XM_011240067.1XP_011238369.1  

    Conserved Domains (5) summary
    cd08753
    Location:306450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77153
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:741927
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9451087
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  11. XM_006501266.2XP_006501329.1  

    Conserved Domains (5) summary
    cd08753
    Location:341485
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:72148
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:787973
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:57131
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9911133
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  12. XM_006501269.2XP_006501332.1  

    Conserved Domains (5) summary
    cd08753
    Location:330474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61137
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:776962
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:46120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9801122
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
  13. XM_006501275.2XP_006501338.1  

    Related
    ENSMUSP00000118123, OTTMUSP00000042232, ENSMUST00000129113, OTTMUST00000079228
    Conserved Domains (5) summary
    cd08753
    Location:290434
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61137
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00160
    Location:736922
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:46120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9401082
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    87655238..87774229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)