Format

Send to:

Choose Destination

Mylk3 myosin light chain kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 213435, updated on 8-May-2016
Official Symbol
Mylk3provided by MGI
Official Full Name
myosin light chain kinase 3provided by MGI
Primary source
MGI:MGI:2443063
See related
Ensembl:ENSMUSG00000031698 Vega:OTTMUSG00000031870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MLCK; D830007F02Rik
Orthologs
Location:
8; 8 C3
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (85324304..85386340, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (87848828..87889223, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene VPS35 retromer complex component Neighboring gene origin recognition complex, subunit 6 Neighboring gene RIKEN cDNA 4921524J17 gene Neighboring gene glutamic pyruvate transaminase (alanine aminotransferase) 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

Markers

Homology

Clone Names

  • MGC169607

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
myosin light chain kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
myosin light chain kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cardiac myofibril assembly ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sarcomere organization ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of vascular permeability involved in acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
sarcomere organization IDA
Inferred from Direct Assay
more info
PubMed 
sarcomere organization ISO
Inferred from Sequence Orthology
more info
 
sarcomerogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
myosin light chain kinase 3
Names
cardiac MLCK
cardiac-MLCK
cardiac-MyBP-C-associated Ca/CaM kinase
cardiac-specific myosin light chain kinase
putative myosin light chain kinase 3
NP_001284541.1
NP_780650.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297612.1NP_001284541.1  myosin light chain kinase 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK146683, AK165216, BB843262
    Consensus CDS
    CCDS80910.1
    UniProtKB/Swiss-Prot
    Q3UIZ8
    UniProtKB/TrEMBL
    D3Z630
    Related
    ENSMUSP00000113389, OTTMUSP00000042110, ENSMUST00000122452, OTTMUST00000079021
    Conserved Domains (2) summary
    smart00220
    Location:361613
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:353613
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
  2. NM_175441.5NP_780650.2  myosin light chain kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_780650.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC134854
    Consensus CDS
    CCDS40422.1
    UniProtKB/Swiss-Prot
    Q3UIZ8
    Related
    ENSMUSP00000034133, OTTMUSP00000042108, ENSMUST00000034133, OTTMUST00000079019
    Conserved Domains (2) summary
    smart00220
    Location:494746
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:486746
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    85324304..85386340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530825.2XP_006530888.1  

    Conserved Domains (2) summary
    smart00220
    Location:334586
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:326586
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
  2. XM_011248347.1XP_011246649.1  

    Conserved Domains (2) summary
    smart00220
    Location:344596
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:336596
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
  3. XM_006530826.2XP_006530889.1  

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    89618765..89675102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. NW_001072099.1 Alternate Mm_Celera

    Range
    1515..17899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)