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    EWSR1 Ewing sarcoma breakpoint region 1 [ Homo sapiens (human) ]

    Gene ID: 2130, updated on 14-May-2013
    Official Symbol
    EWSR1provided by HGNC
    Official Full Name
    Ewing sarcoma breakpoint region 1provided by HGNC
    Primary source
    HGNC:3508
    Locus tag
    AC002059.7
    See related
    Ensembl:ENSG00000182944; HPRD:00592; MIM:133450; Vega:OTTHUMG00000151107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EWS; bK984G1.4
    Summary
    This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
    Location :
    22q12.2
    Sequence :
    Chromosome: 22; NC_000022.10 (29663998..29696515)
    See EWSR1 in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene EMI domain containing 1 Neighboring gene rhomboid domain containing 3 Neighboring gene growth arrest-specific 2 like 1 Neighboring gene RAS-like, family 10, member A

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Rev, p19 rev HIV-1 Rev interacting protein, Ewing sarcoma breakpoint region 1 (EWSR1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with EWSR1 is increased by RRE PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    Q01844 O96019 ACTL6A    HPRD  PubMed  
    Q01844 P01019 AGT    HPRD  PubMed  
    Q01844 P54259 ATN1    HPRD  PubMed  
    Q01844 P54252 ATXN3    HPRD  PubMed  
    Q01844 Q92934 BAD    HPRD  PubMed  
    Q01844 Q99728 BARD1    HPRD  PubMed  
    Q01844 O60238 BNIP3L    HPRD  PubMed  
    Q01844 Q06187 BTK    HPRD  PubMed  
    Q01844 Q8N655 C10orf12    HPRD  PubMed  
    Q01844 Q9NQ32 C11orf16    HPRD  PubMed  
    Q01844 Chromosome 19 open reading frame 57 C19orf57    HPRD  PubMed  
    Q01844 Calmodulin 1 CALM1    HPRD  PubMed  
    Q01844 Q96M83 CCDC7    HPRD  PubMed  
    Q01844 Q7Z6B0 CCDC91    HPRD  PubMed  
    Q01844 Q8N6Q3 CD177    HPRD  PubMed  
    Q01844 P06731 CEACAM5    HPRD  PubMed  
    Q01844 P11597 CETP    HPRD  PubMed  
    Q01844 Q9UEE9 CFDP1    HPRD  PubMed  
    Q01844 Q6PJW8 CNST    HPRD  PubMed  
    Q01844 Q16630 CPSF6    HPRD  PubMed  
    Q01844 Pre-mRNA cleavage factor I, 59 kDa subunit CPSF7    HPRD  PubMed  
    Q01844 Q92793 CREBBP    HPRD  PubMed  
    Q01844 CUE domain containing 2 CUEDC2    HPRD  PubMed  
    Q01844 P78310 CXADR    HPRD  PubMed  
    Q01844 O00273 DFFA    HPRD  PubMed  
    Q01844 DMRTB1 DMRTB1    HPRD  PubMed  
    Q01844 HCG3 gene DNAJB3    HPRD  PubMed  
    Q01844 Q96FJ2 DYNLL2    HPRD  PubMed  
    Q01844 Q14576 ELAVL3    HPRD  PubMed  
    Q01844 P26378 ELAVL4    HPRD  PubMed  
    Q01844 Q9C0D9 EPT1    HPRD  PubMed  
    Q01844 P28715 ERCC5    HPRD  PubMed  
    Q01844 Q01844 EWSR1    HPRD  PubMed  
    Q01844 Q96AQ9 FAM131C    HPRD  PubMed  
    Q01844 P49327 FASN    HPRD  PubMed  
    Q01844 Q01543 FLI1    HPRD  PubMed  
    Q01844 P46926 GNPDA1    HPRD  PubMed  
    Q01844 GC-rich promoter binding protein 1-like 1 GPBP1L1    HPRD  PubMed  
    Q01844 O60381 HBP1    HPRD  PubMed  
    Q01844 Q15011 HERPUD1    HPRD  PubMed  
    Q01844 P17096 HMGA1    HPRD  PubMed  
    Q01844 P54652 HSPA2    HPRD  PubMed  
    Q01844 Q16558 KCNMB1    HPRD  PubMed  
    Q01844 P23276 KEL    HPRD  PubMed  
    Q01844 Sam68 like mammalian protein 1 KHDRBS2    HPRD  PubMed  
    Q01844 Q13601 KRR1    HPRD  PubMed  
    Q01844 Chromosome 19 open reading frame 50 KXD1    HPRD  PubMed  
    Q01844 Q8N6C8 LILRA3    HPRD  PubMed  
    Q01844 P43364 MAGEA11    HPRD  PubMed  
    Q01844 Q8NDC0 MAPK1IP1L    HPRD  PubMed  
    Q01844 P42679 MATK    HPRD  PubMed  
    Q01844 Q99750 MDFI    HPRD  PubMed  
    Q01844 MNS1 MNS1    HPRD  PubMed  
    Q01844 Q9Y676 MRPS18B    HPRD  PubMed  
    Q01844 O60682 MSC    HPRD  PubMed  
    Q01844 P56278 MTCP1    HPRD  PubMed  
    Q01844 Q96QG7 MTMR9    HPRD  PubMed  
    Q01844 Q03426 MVK    HPRD  PubMed  
    Q01844 P60660 MYL6    HPRD  PubMed  
    Q01844 O00160 MYO1F    HPRD  PubMed  
    Q01844 Q9NPC6 MYOZ2    HPRD  PubMed  
    Q01844 Q9H094 NBPF3    HPRD  PubMed  
    Q01844 Q92597 NDRG1    HPRD  PubMed  
    Q01844 O75438 NDUFB1    HPRD  PubMed  
    Q01844 P49821 NDUFV1    HPRD  PubMed  
    Q01844 KIAA0980 protein NINL    HPRD  PubMed  
    Q01844 Q9NVX2 NLE1    HPRD  PubMed  
    Q01844 P16860 NPPB    HPRD  PubMed  
    Q01844 NSUN4 NSUN4    HPRD  PubMed  
    Q01844 Q96CW9 NTNG2    HPRD  PubMed  
    Q01844 Q15365 PCBP1    HPRD  PubMed  
    Q01844 O00330 PDHX    HPRD  PubMed  
    Q01844 O95336 PGLS    HPRD  PubMed  
    Q01844 O15162 PLSCR1    HPRD  PubMed  
    Q01844 P62487 POLR2G    HPRD  PubMed  
    Q01844 Q01851 POU4F1    HPRD  PubMed  
    Q01844 Q01860 POU5F1    HPRD  PubMed  
    Q01844 P17252 PRKCA    HPRD  PubMed  
    Q01844 Phosphoribosyl transferase domain containing 1 PRTFDC1    HPRD  PubMed  
    Q01844 Q8WUY3 PRUNE2    HPRD  PubMed  
    Q01844 Q14289 PTK2B    HPRD  PubMed  
    Q01844 Q96AX2 RAB37    HPRD  PubMed  
    Q01844 P54725 RAD23A    HPRD  PubMed  
    Q01844 RALY RNA binding protein-like RALYL    HPRD  PubMed  
    Q01844 RAS like family 11, member B RASL11B    HPRD  PubMed  
    Q01844 Q93062 RBPMS    HPRD  PubMed  
    Q01844 Homeo box protein PEPP subfamily 2 RHOXF2    HPRD  PubMed  
    Q01844 Q96G75 RMND5B    HPRD  PubMed  
    Q01844 Q96D59 RNF183    HPRD  PubMed  
    Q01844 P62899 RPL31    HPRD  PubMed  
    Q01844 P62244 RPS15A    HPRD  PubMed  
    Q01844 Q9Y467 SALL2    HPRD  PubMed  
    Q01844 Q8N6R1 SERP2    HPRD  PubMed  
    Q01844 Q15637 SF1    HPRD  PubMed  
    Q01844 P43005 SLC1A1    HPRD  PubMed  
    Q01844 Q15797 SMAD1    HPRD  PubMed  
    Q01844 Q13485 SMAD4    HPRD  PubMed  
    Q01844 P09234 SNRPC    HPRD  PubMed  
    Q01844 P81877 SSBP2    HPRD  PubMed  
    Q01844 Q9H5I1 SUV39H2    HPRD  PubMed  
    Q01844 P21675 TAF1    HPRD  PubMed  
    Q01844 O14604 TMSB4Y    HPRD  PubMed  
    Q01844 Q68CL5 TPGS2    HPRD  PubMed  
    Q01844 O94972 TRIM37    HPRD  PubMed  
    Q01844 Q9NQA5 TRPV5    HPRD  PubMed  
    Q01844 O60637 TSPAN3    HPRD  PubMed  
    Q01844 O00295 TULP2    HPRD  PubMed  
    Q01844 Q93009 USP7    HPRD  PubMed  
    Q01844 Q15906 VPS72    HPRD  PubMed  
    Q01844 Q9Y2I8 WDR37    HPRD  PubMed  
    Q01844 Q9H0M0 WWP1    HPRD  PubMed  
    Q01844 O00308 WWP2    HPRD  PubMed  
    Q01844 P61981 YWHAG    HPRD  PubMed  
    Q01844 Q9H869 YY1AP1    HPRD  PubMed  
    Q01844 Q9NYG2 ZDHHC3    HPRD  PubMed  
    Q01844 P49910 ZNF165    HPRD  PubMed  
    Q01844 EIF2AK4     HPRD  PubMed  
    Q01844 Hypothetical protein MGC34821     HPRD  PubMed  
    BioGRID:108431 BioGRID:106601 ACTL6A    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:106690 AGT    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:106889 ARHGDIA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:108156 ATN1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110433 ATXN3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:107048 BAD    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:108431 BioGRID:114118 BLZF1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:107133 BNIP3L    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:107160 BTK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108431 BioGRID:117579 C10orf12    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:121181 C11orf16    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:122590 C19orf57    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:107252 CALM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108431 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:128674 CCDC7    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:120584 CCDC91    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:121389 CD177    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:115690 CD2BP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:119715 CDK12    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:107478 CEACAM5    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:107479 CEBPA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:107498 CETP    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:115697 CFDP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:115778 CHERP    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:127882 CNST    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:116238 CPSF6    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:122957 CPSF7    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:107777 CREBBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108431 BioGRID:122475 CUEDC2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:113743 CUL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:107905 CXADR    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:119920 DCUN1D1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:108040 DFFA    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108025 DHX9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108431 BioGRID:122012 DMRTB1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:135928 DNAJB3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:126680 DYNLL2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:122847 E2F8    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:116450 ECD    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:108431 BioGRID:108310 ELAVL3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108311 ELAVL4    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108317 ELK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108431 BioGRID:108347 EP300    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108348 EPAS1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:124549 EPT1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108385 ERCC5    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108446 EZH2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:131523 FAM131C    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108488 FASN    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:108797 FUS    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:114890 FXR2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:117429 GEMIN5    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:115325 GNPDA1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:117479 GORASP2    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:121896 GPBP1L1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:109187 GSK3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:109286 HAS1    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:115719 HAX1    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:117927 HBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:109316 HDAC2    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:114368 HDAC3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:115060 HERPUD1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113937 HIST1H2BN    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:112480 HLTF    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:109402 HMGA1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:115736 HMGN4    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:116281 HNRNPUL1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:109538 HSPA2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:109824 ILK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:109869 IRF3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:109884 ITGA5    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:109899 ITGB5    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:109954 KCND3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108431 BioGRID:109980 KCNMB1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:109993 KEL    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:128436 KHDRBS2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:115114 KIAA0101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:116284 KRR1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:122501 KXD1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:116216 LILRA3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110284 MAGEA11    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:125030 MAPK1IP1L    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110315 MATK    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:119788 MBD3    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:118161 MCAT    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:110353 MDFI    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:120610 MNS1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:122459 MRP63    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:118797 MRPS18B    BioGRID  PubMed Co-fractionation; Two-hybrid 
    BioGRID:108431 BioGRID:122360 MRPS9    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:114669 MSC    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:117286 MTCH1    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:110618 MTCP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:122455 MTMR9    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110683 MVK    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110721 MYL6    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110638 MYO1F    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:119726 MYOZ2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:123958 NBPF3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:115669 NDRG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:110778 NDUFA5    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:110787 NDUFB1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110802 NDUFV1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:116630 NINL    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:119980 NLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110904 NONO    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110939 NPPB    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:132288 NSUN4    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:124157 NTNG2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:111126 PCBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:111139 PCM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:113737 PDHX    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:117328 PGLS    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:111373 PLSCR1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:111426 POLR2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108431 BioGRID:116301 POLR3A    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:111453 POU4F1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108431 BioGRID:113646 PRRC2A    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:121276 PRTFDC1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:127687 PRUNE2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:108480 PTK2B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108431 BioGRID:116502 PUF60    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:130604 RAB37    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108431 BioGRID:111823 RAD23A    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:126498 RALYL    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:122444 RASL11B    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:116220 RBPMS    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:111923 RFX3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:124119 RHOXF2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:122287 RMND5B    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:127922 RNF168    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:126500 RNF183    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:112079 RPL31    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:112124 RPS15A    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:112204 SALL2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:118881 SAP30BP    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:116609 SCMH1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:132508 SERP2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113368 SF1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108431 BioGRID:115554 SF3B4    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:125107 SFXN1    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:112396 SLC1A1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:129508 SLC22A24    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110264 SMAD4    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:115574 SMNDC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:112515 SNRPC    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108431 BioGRID:112328 SRSF5    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:117164 SSBP2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:112695 SUPT4H1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:122838 SUV39H2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:117059 SUZ12    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:115597 TCIRG1    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:123514 TDRD3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108431 BioGRID:123966 TMEM126A    BioGRID  PubMed Co-fractionation 
    BioGRID:108431 BioGRID:114543 TMSB4Y    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110863 TONSL    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108431 BioGRID:117438 TPGS2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113039 TRAF3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110678 TRIM37    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:124491 TRIM5    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:121137 TRPV5    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113102 TSG101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:115406 TSPAN3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113139 TULP2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:113622 USP7    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:112804 VPS72    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:116363 WBP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108431 BioGRID:116551 WDR37    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113306 WHSC1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:108431 BioGRID:116243 WWP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:116244 WWP2    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:110959 YBX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108431 BioGRID:120540 YY1AP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:116556 ZBTB1    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:119455 ZDHHC3    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:113511 ZNF165    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108431 BioGRID:113524 ZNF184    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:127849 ZNF383    BioGRID  PubMed Two-hybrid 
    BioGRID:108431 BioGRID:1205542 rev    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    RNA-binding protein EWS
    Names
    RNA-binding protein EWS
    Ewings sarcoma EWS-Fli1 (type 1) oncogene

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023240.1 RefSeqGene

      Range
      5001..37518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001163285.1NP_001156757.1  RNA-binding protein EWS isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK225102, AW205707, BC004817, DA013931, DB443651
      Consensus CDS
      CCDS54513.1
      UniProtKB/Swiss-Prot
      Q01844
      Related
      ENSP00000385726, OTTHUMP00000199147, ENST00000406548, OTTHUMT00000321346
      Conserved Domains (3) summary
      COG0724
      Location:357449
      Blast Score: 127
      COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
      cd00590
      Location:362443
      Blast Score: 180
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam00641
      Location:518547
      Blast Score: 124
      zf-RanBP; Zn-finger in Ran binding protein and others
    2. NM_001163286.1NP_001156758.1  RNA-binding protein EWS isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AK056681, AW205707, DA013931, DA051447, DB443651
      Consensus CDS
      CCDS54514.1
      UniProtKB/Swiss-Prot
      Q01844
      Conserved Domains (3) summary
      COG0724
      Location:302394
      Blast Score: 131
      COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
      cd00590
      Location:307388
      Blast Score: 175
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam00641
      Location:463492
      Blast Score: 121
      zf-RanBP; Zn-finger in Ran binding protein and others
    3. NM_001163287.1NP_001156759.1  RNA-binding protein EWS isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, and differs in the 3' UTR and in the presence and absence of exons in the 3' coding region, compared to variant 1. The resulting isoform (5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC000527, DA013931, DB443651
      Consensus CDS
      CCDS54512.1
      UniProtKB/Swiss-Prot
      Q01844
      Related
      ENSP00000327456, OTTHUMP00000199148, ENST00000333395, OTTHUMT00000321348
    4. NM_005243.3NP_005234.1  RNA-binding protein EWS isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AW205707, BC004817, DA013931, DB443651
      Consensus CDS
      CCDS13851.1
      UniProtKB/Swiss-Prot
      Q01844
      Related
      ENSP00000381031, OTTHUMP00000199146, ENST00000397938, OTTHUMT00000321345
      Conserved Domains (3) summary
      COG0724
      Location:358450
      Blast Score: 127
      COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
      cd00590
      Location:363444
      Blast Score: 180
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam00641
      Location:519548
      Blast Score: 124
      zf-RanBP; Zn-finger in Ran binding protein and others
    5. NM_013986.3NP_053733.2  RNA-binding protein EWS isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK056309, AW205707, DA013931, DB443651
      Consensus CDS
      CCDS13852.2
      UniProtKB/Swiss-Prot
      Q01844
      Related
      ENSP00000400142, OTTHUMP00000217043, ENST00000414183, OTTHUMT00000358290
      Conserved Domains (3) summary
      COG0724
      Location:363455
      Blast Score: 131
      COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
      cd00590
      Location:368449
      Blast Score: 182
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam00641
      Location:524553
      Blast Score: 125
      zf-RanBP; Zn-finger in Ran binding protein and others

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p10 Primary Assembly

      Range
      29663998..29696515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      12628341..12660759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018933.1 Alternate CHM1_1.0

      Range
      13585771..13618281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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