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Hk3 hexokinase 3 [ Mus musculus (house mouse) ]

Gene ID: 212032, updated on 8-May-2016
Official Symbol
Hk3provided by MGI
Official Full Name
hexokinase 3provided by MGI
Primary source
MGI:MGI:2670962
See related
Ensembl:ENSMUSG00000025877 Vega:OTTMUSG00000032679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HK III; HK-III
Orthologs
Location:
13; 13 B1
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (55005985..55021472, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55107347..55122695, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930526F13 gene Neighboring gene predicted gene, 31313 Neighboring gene unc-5 netrin receptor A Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene zinc finger protein 346

Markers

Homology

Clone Names

  • MGC143940

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
glucose binding IEA
Inferred from Electronic Annotation
more info
 
hexokinase activity ISO
Inferred from Sequence Orthology
more info
 
hormone binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
cellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrogen peroxide-mediated programmed cell death ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
hexokinase-3
Names
hexokinase type III
NP_001028417.1
NP_001193319.1
NP_001193320.1
NP_001193321.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033245.4NP_001028417.1  hexokinase-3 isoform 1

    See identical proteins and their annotated locations for NP_001028417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC154610, AK171580, BI133441
    Consensus CDS
    CCDS26538.1
    UniProtKB/Swiss-Prot
    Q3TRM8
    Related
    ENSMUSP00000051215, OTTMUSP00000043473, ENSMUST00000052949, OTTMUST00000081308
    Conserved Domains (3) summary
    cd00012
    Location:537707
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    PTZ00107
    Location:482913
    PTZ00107; hexokinase; Provisional
    pfam03727
    Location:676913
    Hexokinase_2; Hexokinase
  2. NM_001206390.1NP_001193319.1  hexokinase-3 isoform 1

    See identical proteins and their annotated locations for NP_001193319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS26538.1
    UniProtKB/Swiss-Prot
    Q3TRM8
    Related
    ENSMUSP00000123233, OTTMUSP00000043475, ENSMUST00000126234, OTTMUST00000081310
    Conserved Domains (3) summary
    cd00012
    Location:537707
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    PTZ00107
    Location:482913
    PTZ00107; hexokinase; Provisional
    pfam03727
    Location:676913
    Hexokinase_2; Hexokinase
  3. NM_001206391.1NP_001193320.1  hexokinase-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS56884.1
    UniProtKB/TrEMBL
    E9Q8S8
    Related
    ENSMUSP00000116717, OTTMUSP00000043476, ENSMUST00000123097, OTTMUST00000081311
    Conserved Domains (3) summary
    cd00012
    Location:492662
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    PTZ00107
    Location:429868
    PTZ00107; hexokinase; Provisional
    pfam03727
    Location:631868
    Hexokinase_2; Hexokinase
  4. NM_001206392.1NP_001193321.1  hexokinase-3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS56883.1
    UniProtKB/TrEMBL
    E9Q3Z4
    Related
    ENSMUSP00000115227, OTTMUSP00000043474, ENSMUST00000153665, OTTMUST00000081309
    Conserved Domains (3) summary
    cd00012
    Location:482652
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    PTZ00107
    Location:427858
    PTZ00107; hexokinase; Provisional
    pfam03727
    Location:621858
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    55005985..55021472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517193.2XP_006517256.1  

    Conserved Domains (3) summary
    cd00012
    Location:506676
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    PTZ00107
    Location:451882
    PTZ00107; hexokinase; Provisional
    pfam03727
    Location:645882
    Hexokinase_2; Hexokinase

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    56066913..56082309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)