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ETV3 ETS variant 3 [ Homo sapiens (human) ]

Gene ID: 2117, updated on 8-May-2016
Official Symbol
ETV3provided by HGNC
Official Full Name
ETS variant 3provided by HGNC
Primary source
HGNC:HGNC:3492
See related
Ensembl:ENSG00000117036 HPRD:01282; MIM:164873; Vega:OTTHUMG00000034298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PE1; METS; PE-1; bA110J1.4
Orthologs
Location:
1q21-q23
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (157121191..157138591, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157094459..157108383, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene keratin 8 pseudogene 45 Neighboring gene ETS variant 3 like Neighboring gene cytochrome c, somatic pseudogene 52 Neighboring gene uncharacterized LOC105371456 Neighboring gene uncharacterized LOC105371455 Neighboring gene SLAM family member 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of ets variant 3 (ETV3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ79173

Gene Ontology Provided by GOA

Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription repressor complex IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
ETS translocation variant 3
Names
ETS domain transcriptional repressor PE1
ets variant gene 3, ETS family transcriptional repressor
mitogenic Ets transcriptional suppressor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145312.1NP_001138784.1  ETS translocation variant 3 isoform 1

    See identical proteins and their annotated locations for NP_001138784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and predicted protein isoform (1).
    Source sequence(s)
    AK316274
    Consensus CDS
    CCDS44250.1
    UniProtKB/Swiss-Prot
    P41162
    Related
    ENSP00000357175, OTTHUMP00000032197, ENST00000368192, OTTHUMT00000082843
    Conserved Domains (1) summary
    pfam00178
    Location:34118
    Ets; Ets-domain
  2. NM_005240.1NP_005231.1  ETS translocation variant 3 isoform 2

    See identical proteins and their annotated locations for NP_005231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents a shorter transcript, compared to transcript variant 1. The predicted protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC022868
    Consensus CDS
    CCDS1164.1
    UniProtKB/Swiss-Prot
    P41162
    Related
    ENSP00000327316, OTTHUMP00000032196, ENST00000326786, OTTHUMT00000082842
    Conserved Domains (1) summary
    pfam00178
    Location:34118
    Ets; Ets-domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    157121191..157138591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711210.2XP_006711273.1  

    See identical proteins and their annotated locations for XP_006711273.1

    UniProtKB/Swiss-Prot
    P41162
    Conserved Domains (1) summary
    pfam00178
    Location:34118
    Ets; Ets-domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    158490846..158504773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)