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    ESR1 estrogen receptor 1 [ Homo sapiens ]

    Gene ID: 2099, updated on 24-May-2012

    Summary

    Official Symbol
    ESR1provided by HGNC
    Official Full Name
    estrogen receptor 1provided by HGNC
    Primary source
    HGNC:3467
    Locus tag
    RP1-130E4.1
    See related
    Ensembl:ENSG00000091831; HPRD:00589; MIM:133430; Vega:OTTHUMG00000016103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ER; ESR; Era; ESRA; NR3A1; DKFZp686N23123
    Summary
    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    6q25.1
    Sequence :
    Chromosome: 6; NC_000006.11 (152011631..152424409)
    See ESR1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene chromosome 6 open reading frame 211 Neighboring gene coiled-coil domain containing 170 Neighboring gene spectrin repeat containing, nuclear envelope 1 Neighboring gene uncharacterized LOC100505475 Neighboring gene Nanog homeobox pseudogene 11

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env 17beta-estradiol (17beta-E2) protects human neuroblastoma cells from cell death elicited by HIV-1 gp120; estrogen receptor antagonists antagonize 17beta-E2-mediated inhibition gp120-induced cell death PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000116.1 NP_006296.1 ANP32A    BIND  PubMed ER-alpha interacts with pp32. 
    NP_000116.1 NC_000017.9 AXIN2    BIND  PubMed ER-alpha interacts with the Axin2 promoter. 
    NP_000116.1 NP_005863.1 BCAS2    BIND  PubMed BCAS2 interacts with ER-alpha. This interaction was modeled on a demonstrated interaction between human BCAS2 and ER-alpha from an unspecified species. 
    NP_000116.1 NP_001478.1 BLOC1S1    BIND  PubMed ER interacts with MICoA 
    NP_000116.1 NC_000011.8 CCND1    BIND  PubMed ER-alpha interacts with cyclin D1 promoter. 
    NP_000116.1 NP_001269.3 CHUK    BIND  PubMed IKK-alpha interacts with ER-alpha. 
    NP_000116.1 NP_001895.1 CTNNB1    BIND  PubMed beta-catenin interacts with ER-alpha. 
    NP_000116.1 DDX17    BIND  PubMed ESR1 (ER-alpha) interacts with an unspecified isoform of DDX17 (p72). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and DDX17 from an unspecified species. 
    NP_000116.1 NP_004387.1 DDX5    BIND  PubMed ESR1 (ER-alpha) interacts with DDX5 (p68). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and DDX5 from an unspecified species. 
    NP_000116.1 NC_000008.9 EBAG9    BIND  PubMed ER-alpha interacts with EBAG9 promoter. 
    NP_000116.1 NP_003748.1 EIF3I    BIND  PubMed ER alpha interacts with TRIP1. This interaction was modeled on a demonstrated interaction between TRIP1 from an unspecified source and human ER alpha. 
    NP_000116.1 NP_001420.2 EP300    BIND  PubMed EP300 (p300) acetylates ESR1 (ER-alpha). This interaction was modeled on a demonstrated interaction between EP300 from an unspecified species and ESR1 from an unspecified species. 
    NP_000116.1 NP_001428.1 ESR2    BIND  PubMed ER alpha interacts with ER beta to form heterodimer. This interaction was modeled on a demonstrated interaction between human ER alpha and mouse ER beta. 
    NP_000116.1 NP_004955.2 HDAC1    BIND  PubMed ER-alpha interacts with HDAC1. 
    NP_000116.1 NP_002219.1 JUN    BIND  PubMed ER-alpha interacts with c-Jun. This interaction was modeled on a demonstrated interaction between human ER-alpha, and mouse c-Jun. 
    NP_000116.1 NP_002220.1 JUNB    BIND  PubMed ER-alpha interacts with JunB. This interaction was modeled on a demonstrated interaction between human ER-alpha and mouse JunB. 
    NP_000116.1 NP_005047.1 KDM5A    BIND  PubMed Rbp2 interacts with ER. 
    NP_000116.1 NP_004765.2 MED1    BIND  PubMed ESR1 (ER-alpha) interacts with PPARBP (TRAP220). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and PPARBP from an unspecified species. 
    NP_000116.1 NP_002425.1 MPG    BIND  PubMed ESR1 (ER-alpha) interacts with MPG. 
    NP_000116.1 NC_000008.9 MYC    BIND  PubMed ER-alpha interacts with c-myc promoter. 
    NP_000116.1 NP_003734.3 NCOA1    BIND  PubMed ER-alpha interacts with SRC-1 
    NP_000116.1 NP_006531.1 NCOA2    BIND  PubMed ER alpha interacts with TIF2. This interaction was modeled on a demonstrated interaction between TIF2 from an unspecified source and human ER alpha. 
    NP_000116.1 NP_006525.2 NCOA3    BIND  PubMed SRC-3 interacts with ER. This interaction was modelled on a demonstrated interaction between human SRC-3 and ER from an unspecified species. 
    NP_000116.1 NP_858045.1 NCOA3    BIND  PubMed TRAM-1 interacts with ER. 
    NP_000116.1 NP_006302.2 NCOR1    BIND  PubMed ESR1 (ER-alpha) interacts with NCOR1 (N-CoR). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and human NCOR1. 
    NP_000116.1 NP_006303.2 NCOR2    BIND  PubMed ESR1 (ER-alpha) interacts with NCOR2 (SMRT). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and NCOR2 from an unspecified species. 
    NP_000116.1 NP_003480.2 NRIP1    BIND  PubMed ESR1 (ER-alpha) interacts with NRIP1 (RIP140). This interaction was modelled on a demonstrated interaction between human ESR1 and mouse NRIP1. 
    NP_000116.1 AY525610.1 PGR    BIND  PubMed ER-alpha interacts with the PgRA promoter. 
    NP_000116.1 AY525610.1 PGR    BIND  PubMed ER-alpha interacts with the PgRB promoter. 
    NP_000116.1 NP_009204.1 PHB2    BIND  PubMed ER-alpha interacts with REA 
    NP_000116.1 NP_996845.1 PRMT2    BIND  PubMed PRMT2 interacts with ER-alpha. 
    NP_000116.1 NP_060577.2 RBM23    BIND  PubMed RBM23 (CAPER-beta) interacts with ESR1(ER-alpha) 
    NP_000116.1 NP_003143.2 STAT5A    BIND  PubMed ER-alpha interacts with STAT5a. 
    NP_000116.1 NC_000021.7 TFF1    BIND  PubMed ER-alpha interacts with the pS2 promoter. 
    NP_000116.1 NT_086913.1 TFF1    BIND  PubMed ER-alpha interacts with pS2. 
    NP_000116.1 NP_000537.2 TP53    BIND  PubMed P53 interacts with ER-alpha. 
    NP_000116.1 AAB63585.1 TRIM24    BIND  PubMed ESR1 (ER-alpha) interacts with TIF1. This interaction was modeled on a demonstrated interaction between human ESR1 and mouse TIF1. 
    NP_000116.1 NP_003487.1 TRRAP    BIND  PubMed ESR1 (ER-alpha) interacts with TRRAP. This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and TRRAP from an unspecified species. 
    NP_000116.1 AB038162.1     BIND  PubMed ER-alpha interacts with TFF1/pS2 ERE. 
    NP_000116.1 NC_000002.9     BIND  PubMed ER-alpha interacts with GREB1 ERE. 
    NP_000116.1 NC_000016.8     BIND  PubMed ER-alpha interacts with ABCA3 ERE. 
    NP_000116.1 NC_000021.7     BIND  PubMed ER-alpha interacts with NRIP1 ERE. 
    NP_000116.1 NP_002383.1     BIND  PubMed hdm2 interacts with ER-alpha. 
    NP_000116.1     BIND  PubMed ER-alpha interacts with estrogen. 
    NP_000116.2 NC_000022.8 AP1B1    BIND  PubMed ER interacts with AP1B1. 
    NP_000116.2 NC_000022.8 ASCC2    BIND  PubMed ER interacts with ASC1p100. 
    NP_000116.2 NC_000021.7 BAGE3    BIND  PubMed ER interacts with BAGE3. 
    NP_000116.2 NC_000022.8 CELSR1    BIND  PubMed ER interacts with CELSR1. 
    NP_000116.2 NC_000022.8 CSNK1E    BIND  PubMed ER interacts with CSNK1E. 
    NP_000116.2 NC_000022.8 CYB5R3    BIND  PubMed ER interacts with CYB5R3. 
    NP_000116.2 NC_000021.7 DSCAM    BIND  PubMed ER interacts with DSCAM-1 enhancer. 
    NP_000116.2 NP_963850.1 FHL2    BIND  PubMed ER-alpha interacts with FHL2. 
    NP_000116.2 NC_000021.7 LINC00479    BIND  PubMed ER interacts with C21orf129. 
    NP_000116.2 NC_000021.7 LOC441967    BIND  PubMed ER interacts with LOC441967. 
    NP_000116.2 NC_000021.7 NCAM2    BIND  PubMed ER interacts with NCAM2. 
    NP_000116.2 NC_000021.7 NRIP1    BIND  PubMed ER interacts with NRIP-1 enhancer. 
    NP_000116.2 NP_057250.1 PIAS1    BIND  PubMed ER-alpha interacts with PIAS1. 
    NP_000116.2 NC_000022.8 SFI1    BIND  PubMed ER interacts with SFI1. 
    NP_000116.2 NC_000021.7 SLC37A1    BIND  PubMed ER interacts with SLC37A1. 
    NP_000116.2 NC_000022.8 SNAP29    BIND  PubMed ER interacts with SNAP29. 
    NP_000116.2 NC_000021.7 SOD1    BIND  PubMed ER interacts with SOD-1 enhancer. 
    NP_000116.2 NC_000021.7 TFF1    BIND  PubMed ER interacts with TFF-1 promoter. 
    NP_000116.2 NC_000021.7 TFF1    BIND  PubMed ER interacts with TFF-1 enhancer. 
    NP_000116.2 NC_000022.8 THOC5    BIND  PubMed ER interacts with C22orf19. 
    NP_000116.2 UBE2I    BIND  PubMed ER-alpha interacts with an unspecified isoform of Ubc9. 
    NP_000116.2 NC_000022.8 XBP1    BIND  PubMed ER interacts with XBP-1 enhancer. 
    NP_000116.2 NC_000021.7     BIND  PubMed ER interacts with chromosome 21. 
    NP_000116.2 NC_000022.8     BIND  PubMed ER interacts with chromosome 22. 
    P03372 P35869 AHR    HPRD  PubMed  
    P03372 Q12802 AKAP13    HPRD  PubMed  
    P03372 P31749 AKT1    HPRD  PubMed  
    P03372 P31751 AKT2    HPRD  PubMed  
    P03372 P10275 AR    HPRD  PubMed  
    P03372 O94989 ARHGEF15    HPRD  PubMed  
    P03372 P27540 ARNT    HPRD  PubMed  
    P03372 Q99933 BAG1    HPRD  PubMed  
    P03372 P56945 BCAR1    HPRD  PubMed  
    P03372 O75934 BCAS2    HPRD  PubMed  
    P03372 P23560 BDNF    HPRD  PubMed  
    P03372 P38398 BRCA1    HPRD  PubMed  
    P03372 Calmodulin 1 CALM1    HPRD  PubMed  
    P03372 Calmodulin 3 CALM3    HPRD  PubMed  
    P03372 P62158 CALM3    HPRD  PubMed  
    P03372 Q03135 CAV1    HPRD  PubMed  
    P03372 P24385 CCND1    HPRD  PubMed  
    P03372 P51946 CCNH    HPRD  PubMed  
    P03372 O60563 CCNT1    HPRD  PubMed  
    P03372 P30305 CDC25B    HPRD  PubMed  
    P03372 P50613 CDK7    HPRD  PubMed  
    P03372 P17676 CEBPB    HPRD  PubMed  
    P03372 Q3L8U1 CHD9    HPRD  PubMed  
    P03372 O15111 CHUK    HPRD  PubMed  
    P03372 Q99966 CITED1    HPRD  PubMed  
    P03372 Q8WX92 COBRA1    HPRD  PubMed  
    P03372 Q92905 COPS5    HPRD  PubMed  
    P03372 Q92793 CREBBP    HPRD  PubMed  
    P03372 P67870 CSNK2B    HPRD  PubMed  
    P03372 P35222 CTNNB1    HPRD  PubMed  
    P03372 CUE domain containing 2 CUEDC2    HPRD  PubMed  
    P03372 Q13620 CUL4B    HPRD  PubMed  
    P03372 P17844 DDX5    HPRD  PubMed  
    P03372 Q8TDD1 DDX54    HPRD  PubMed  
    P03372 Estrogen receptor binding protein DNTTIP2    HPRD  PubMed  
    P03372 P33316 DUT    HPRD  PubMed  
    P03372 P00533 EGFR    HPRD  PubMed  
    P03372 Q13347 EIF3I    HPRD  PubMed  
    P03372 Q09472 EP300    HPRD  PubMed  
    P03372 P04626 ERBB2    HPRD  PubMed  
    P03372 P03372 ESR1    HPRD  PubMed  
    P03372 Q92731 ESR2    HPRD  PubMed  
    P03372 P11474 ESRRA    HPRD  PubMed  
    P03372 Q14192 FHL2    HPRD  PubMed  
    P03372 Q13045 FLII    HPRD  PubMed  
    P03372 Q12778 FOXO1    HPRD  PubMed  
    P03372 O43524 FOXO3    HPRD  PubMed  
    P03372 P98177 FOXO4    HPRD  PubMed  
    P03372 O75293 GADD45B    HPRD  PubMed  
    P03372 O95257 GADD45G    HPRD  PubMed  
    P03372 P63096 GNAI1    HPRD  PubMed  
    P03372 P62993 GRB2    HPRD  PubMed  
    P03372 Q00403 GTF2B    HPRD  PubMed  
    P03372 P32780 GTF2H1    HPRD  PubMed  
    P03372 Cardiac lineage protein 1 HEXIM1    HPRD  PubMed  
    P03372 P41235 HNF4A    HPRD  PubMed  
    P03372 P07900 HSP90AA1    HPRD  PubMed  
    P03372 P08238 HSP90AB1    HPRD  PubMed  
    P03372 P34932 HSPA4    HPRD  PubMed  
    P03372 P08069 IGF1R    HPRD  PubMed  
    P03372 P61371 ISL1    HPRD  PubMed  
    P03372 Q13352 ITGB3BP    HPRD  PubMed  
    P03372 P05412 JUN    HPRD  PubMed  
    P03372 P17275 JUNB    HPRD  PubMed  
    P03372 P17535 JUND    HPRD  PubMed  
    P03372 Q92993 KAT5    HPRD  PubMed  
    P03372 P29375 KDM5A    HPRD  PubMed  
    P03372 Q12756 KIF1A    HPRD  PubMed  
    P03372 P06239 LCK    HPRD  PubMed  
    P03372 Q9Y6C7 LINC00312    HPRD  PubMed  
    P03372 P28482 MAPK1    HPRD  PubMed  
    P03372 Q16539 MAPK14    HPRD  PubMed  
    P03372 P27361 MAPK3    HPRD  PubMed  
    P03372 Q00987 MDM2    HPRD  PubMed  
    P03372 Q15648 MED1    HPRD  PubMed  
    P03372 O75448 MED24    HPRD  PubMed  
    P03372 Q9HBH9 MKNK2    HPRD  PubMed  
    P03372 O14686 MLL2    HPRD  PubMed  
    P03372 Q96T76 MMS19    HPRD  PubMed  
    P03372 P51948 MNAT1    HPRD  PubMed  
    P03372 P29372 MPG    HPRD  PubMed  
    P03372 Q13330 MTA1    HPRD  PubMed  
    P03372 Q9Y6C9 MTCH2    HPRD  PubMed  
    P03372 Q14764 MVP    HPRD  PubMed  
    P03372 Q15788 NCOA1    HPRD  PubMed  
    P03372 Q15596 NCOA2    HPRD  PubMed  
    P03372 Q9Y6Q9 NCOA3    HPRD  PubMed  
    P03372 Q14686 NCOA6    HPRD  PubMed  
    P03372 Q8NI08 NCOA7    HPRD  PubMed  
    P03372 O75376 NCOR1    HPRD  PubMed  
    P03372 Q9Y618 NCOR2    HPRD  PubMed  
    P03372 P19838 NFKB1    HPRD  PubMed  
    P03372 P01160 NPPA    HPRD  PubMed  
    P03372 P51843 NR0B1    HPRD  PubMed  
    P03372 Q15466 NR0B2    HPRD  PubMed  
    P03372 Q96RI1 NR1H4    HPRD  PubMed  
    P03372 P13056 NR2C1    HPRD  PubMed  
    P03372 P49116 NR2C2    HPRD  PubMed  
    P03372 P10589 NR2F1    HPRD  PubMed  
    P03372 P10588 NR2F6    HPRD  PubMed  
    P03372 P48552 NRIP1    HPRD  PubMed  
    P03372 Q96L73 NSD1    HPRD  PubMed  
    P03372 Q13153 PAK1    HPRD  PubMed  
    P03372 Q9NQU5 PAK6    HPRD  PubMed  
    P03372 Q8IZL8 PELP1    HPRD  PubMed  
    P03372 P06401 PGR    HPRD  PubMed  
    P03372 Q99623 PHB2    HPRD  PubMed  
    P03372 O75925 PIAS1    HPRD  PubMed  
    P03372 Q9Y6X2 PIAS3    HPRD  PubMed  
    P03372 P27986 PIK3R1    HPRD  PubMed  
    P03372 Q92569 PIK3R3    HPRD  PubMed  
    P03372 Q9NPJ4 PNRC2    HPRD  PubMed  
    P03372 Q9H9Y6 POLR1B    HPRD  PubMed  
    P03372 O15514 POLR2D    HPRD  PubMed  
    P03372 P14859 POU2F1    HPRD  PubMed  
    P03372 Q01851 POU4F1    HPRD  PubMed  
    P03372 Q12837 POU4F2    HPRD  PubMed  
    P03372 Q9UBK2 PPARGC1A    HPRD  PubMed  
    P03372 Q86YN6 PPARGC1B    HPRD  PubMed  
    P03372 Q13029 PRDM2    HPRD  PubMed  
    P03372 P17612 PRKACA    HPRD  PubMed  
    P03372 Q99873 PRMT1    HPRD  PubMed  
    P03372 P55345 PRMT2    HPRD  PubMed  
    P03372 P62195 PSMC5    HPRD  PubMed  
    P03372 Q15185 PTGES3    HPRD  PubMed  
    P03372 P18031 PTPN1    HPRD  PubMed  
    P03372 P29350 PTPN6    HPRD  PubMed  
    P03372 P10276 RARA    HPRD  PubMed  
    P03372 O43251 RBFOX2    HPRD  PubMed  
    P03372 Q86U06 RBM23    HPRD  PubMed  
    P03372 Q14498 RBM39    HPRD  PubMed  
    P03372 Q04206 RELA    HPRD  PubMed  
    P03372 Q9GZR2 REXO4    HPRD  PubMed  
    P03372 Regulatory factor X 4 RFX4    HPRD  PubMed  
    P03372 P49796 RGS3    HPRD  PubMed  
    P03372 Q9UBS8 RNF14    HPRD  PubMed  
    P03372 P78317 RNF4    HPRD  PubMed  
    P03372 Q15418 RPS6KA1    HPRD  PubMed  
    P03372 P51812 RPS6KA3    HPRD  PubMed  
    P03372 P19793 RXRA    HPRD  PubMed  
    P03372 Q15424 SAFB    HPRD  PubMed  
    P03372 Q14151 SAFB2    HPRD  PubMed  
    P03372 P29353 SHC1    HPRD  PubMed  
    P03372 HUEL SLC30A9    HPRD  PubMed  
    P03372 Q15796 SMAD2    HPRD  PubMed  
    P03372 P84022 SMAD3    HPRD  PubMed  
    P03372 Q13485 SMAD4    HPRD  PubMed  
    P03372 P51531 SMARCA2    HPRD  PubMed  
    P03372 P51532 SMARCA4    HPRD  PubMed  
    P03372 Q6STE5 SMARCD3    HPRD  PubMed  
    P03372 Q969G3 SMARCE1    HPRD  PubMed  
    P03372 Q07889 SOS1    HPRD  PubMed  
    P03372 P08047 SP1    HPRD  PubMed  
    P03372 Q02447 SP3    HPRD  PubMed  
    P03372 P12931 SRC    HPRD  PubMed  
    P03372 P36956 SREBF1    HPRD  PubMed  
    P03372 P42229 STAT5A    HPRD  PubMed  
    P03372 O43815 STRN    HPRD  PubMed  
    P03372 Q9UNE7 STUB1    HPRD  PubMed  
    P03372 Q12962 TAF10    HPRD  PubMed  
    P03372 Q03518 TAP1    HPRD  PubMed  
    P03372 P20226 TBP    HPRD  PubMed  
    P03372 Q9UGU0 TCF20    HPRD  PubMed  
    P03372 Q13569 TDG    HPRD  PubMed  
    P03372 P10827 THRA    HPRD  PubMed  
    P03372 P37243 THRB    HPRD  PubMed  
    P03372 Q92956 TNFRSF14    HPRD  PubMed  
    P03372 P04637 TP53    HPRD  PubMed  
    P03372 O15164 TRIM24    HPRD  PubMed  
    P03372 Q13263 TRIM28    HPRD  PubMed  
    P03372 Q8IWR1 TRIM59    HPRD  PubMed  
    P03372 Q15650 TRIP4    HPRD  PubMed  
    P03372 Q9Y4A5 TRRAP    HPRD  PubMed  
    P03372 P49815 TSC2    HPRD  PubMed  
    P03372 P68363 TUBA1B    HPRD  PubMed  
    P03372 P07437 TUBB    HPRD  PubMed  
    P03372 P63279 UBE2I    HPRD  PubMed  
    P03372 P22415 USF1    HPRD  PubMed  
    P03372 Q5MNZ9 WIPI1    HPRD  PubMed  
    P03372 P17861 XBP1    HPRD  PubMed  
    P03372 Q04917 YWHAH    HPRD  PubMed  
    P03372 Q05516 ZBTB16    HPRD  PubMed  
    P03372 Q13105 ZBTB17    HPRD  PubMed  
    P03372 Q8TD17 ZNF398    HPRD  PubMed  
    BioGRID:108403 BioGRID:106575 ACTB    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:106585 ACTC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:106596 ACTN4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:115404 ACTR2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:115403 ACTR3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:106699 AHR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:121558 AHRR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:116383 AKAP13    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:106710 AKT1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108403 BioGRID:106711 AKT2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108403 BioGRID:106889 ARHGDIA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:114528 ASH2L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:118827 ATAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:107049 BAG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:114934 BCAR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:108403 BioGRID:107305 CAV1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:107333 CCNC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:107342 CCNH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:107429 CDC25B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:107457 CDK7    BioGRID  PubMed Biochemical Activity 
    BioGRID:108403 BioGRID:107458 CDK8    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:107460 CDKN1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:107479 CEBPA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:107480 CEBPB    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:108403 BioGRID:107532 CHD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:110572 CITED1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:117421 COBRA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:122475 CUEDC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:113587 DAP3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:115776 DDX17    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:108020 DDX3X    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:122503 DDX54    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:119052 DNTTIP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:108187 DUT    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:108376 ERBB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western; Two-hybrid 
    BioGRID:108403 BioGRID:108404 ESR2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:108565 FHL2    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:108578 FKBP4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:108579 FKBP5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:108603 FLII    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:108636 FOS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:108597 FOXO1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:110449 FOXO4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:108014 GADD45A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:116117 GADD45G    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:116995 GRIP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:109189 GSN    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:109214 GTF2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:109220 GTF2H1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108403 BioGRID:201638 Gadd45b    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:108403 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:114368 HDAC3    BioGRID  PubMed Co-localization 
    BioGRID:108403 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:115331 HDAC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:119613 HDAC7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:115083 HDAC9    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:109701 IGF1R    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:109833 ING1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:109874 IRS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:114209 IRS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:109877 ISL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:113703 KAT6A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:116667 KDM1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:116669 KDM4B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:108403 BioGRID:111862 KDM5A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:107029 KIF1A    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:107153 KLF5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:124093 LCOR    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:114384 LDB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:114113 LMO4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:120905 LRIF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111580 MAPK1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108403 BioGRID:114445 MBD2    BioGRID  PubMed Co-localization 
    BioGRID:108403 BioGRID:110358 MDM2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:123974 MED10    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:115293 MED12    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:115294 MED13    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:114699 MED14    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:115342 MED16    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:114830 MED17    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:114862 MED20    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:114807 MED21    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:114829 MED23    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:115196 MED24    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:123607 MED25    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:115319 MED6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:114833 MED7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:110384 MEN1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108403 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:113758 MLL2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:110474 MNAT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:110490 MPG    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:110573 MSH2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:109211 MSH6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:114562 MTA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:114652 MTA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:121568 MTA3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:117287 MTCH2    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:110669 MUC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:115286 MVP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:110721 MYL6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:110725 MYO1C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:110737 MYOD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:114200 NCOA1    BioGRID  PubMed Affinity Capture-Western; FRET; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:115761 NCOA2    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; FRET; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:113726 NCOA4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:116691 NCOA6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:126419 NCOA7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:32229 NGG1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:110938 NPPA    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:114012 NR0B2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:113033 NR2C1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:113034 NR2C2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:112883 NR2F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:108375 NR2F6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:113843 NRIP1    BioGRID  PubMed Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:250721 Nr0b2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:201839 Nr1i2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:201855 Nsd1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:120751 OTUB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108403 BioGRID:121251 PAK6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:114572 PDLIM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:117973 PELP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:111246 PGC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111264 PHB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:116459 PHB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:114124 PIAS1    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:114523 PIAS2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:111314 PIK3R2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:120768 PNRC2    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:111426 POLR2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:111447 POU2F1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111448 POU2F2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111453 POU4F1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:111454 POU4F2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:116097 PPARGC1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:126361 PPARGC1B    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:111477 PPID    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:113575 PRDM2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108403 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:109512 PRMT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:109511 PRMT2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:111678 PSMC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111700 PTEN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:115952 PTGES3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111724 PTMA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111863 RBBP4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:111864 RBBP5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:111865 RBBP6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:111866 RBBP7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:117087 RBFOX2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:114952 RBM39    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:121375 REXO4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:119319 RLIM    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:111974 RNF4    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:112061 RPL18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:112049 RPL7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:112050 RPL7A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:112094 RPLP0    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:112105 RPS4X    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:112109 RPS6KA1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108403 BioGRID:112111 RPS6KA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:112116 RPS8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:112117 RPS9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108403 BioGRID:112201 SAFB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:115022 SAFB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:123332 SETD7    BioGRID  PubMed Biochemical Activity; Protein-peptide 
    BioGRID:108403 BioGRID:113368 SF1    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:117195 SGK3    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:108403 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:112388 SKI    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:112389 SKIL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:112479 SMARCA2    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:112485 SMARCC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:112486 SMARCD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:112489 SMARCE1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:122268 SMYD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:112538 SOS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:108403 BioGRID:112551 SP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:112553 SP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:115329 SRA1    BioGRID  PubMed Phenotypic Enhancement; Protein-RNA 
    BioGRID:108403 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:112653 STAT5A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:112707 SVIL    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:115737 TADA3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:114484 TAF1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:114483 TAF1B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:112855 TDG    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:113008 TOP2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:113010 TP53    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:117032 TRAM1    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:114333 TRIM24    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:113500 TRIM25    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108403 BioGRID:114735 TRIP4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108403 BioGRID:113603 TUBA1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:123347 TUBB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:221609 Tada3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:108403 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:116272 WDR5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108403 BioGRID:113331 XBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108403 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108403 BioGRID:116168 YWHAQ    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:113498 ZBTB16    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108403 BioGRID:121600 ZNF398    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    estrogen receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    estrogen response element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nitric-oxide synthase regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    steroid hormone receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    type 1 metabotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Sertoli cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    antral ovarian follicle growth IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estrogen stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell development IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell proliferation involved in mammary gland duct elongation IEA
    Inferred from Electronic Annotation
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    intracellular estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular estrogen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland branching involved in pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
     
    negative regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuroprotection IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
     
    positive regulation of nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
     
    positive regulation of retinoic acid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of survival gene product expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    prostate epithelial cord elongation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of branching involved in prostate gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    steroid hormone mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    steroid hormone mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    PubMed 
    uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    vagina development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    T-tubule IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mitochondrial part IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus NAS
    Non-traceable Author Statement
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    terminal button IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    estrogen receptor
    Names
    estrogen receptor
    ER-alpha
    estradiol receptor
    estrogen nuclear receptor alpha
    estrogen receptor alpha delta 4 +49 isoform
    nuclear receptor subfamily 3 group A member 1
    estrogen receptor alpha 3*,4,5,6,7*/822 isoform
    estrogen receptor alpha delta 4*,5,6,7*/654 isoform
    estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform
    estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform
    estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008493.1 RefSeqGene

      Range
      5001..417779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000125.3NP_000116.2  estrogen receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses the most proximal promoter. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL078582, AL356311, BC128573, BE084831
      Consensus CDS
      CCDS5234.1
      UniProtKB/TrEMBL
      G4XH65
      UniProtKB/Swiss-Prot
      P03372
      Related
      ENSP00000206249, OTTHUMP00000017718, ENST00000206249, OTTHUMT00000043308
      Conserved Domains (4) summary
      cd06949
      Location:310547
      Blast Score: 1030
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180248
      Blast Score: 435
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Blast Score: 339
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:552595
      Blast Score: 172
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    2. NM_001122740.1NP_001116212.1  estrogen receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a different promoter, compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL078582, BC128573, BE084831, U68067
      Consensus CDS
      CCDS5234.1
      UniProtKB/TrEMBL
      G4XH65
      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      Q9UBT1
      Related
      ENSP00000387500, ENST00000443427
      Conserved Domains (4) summary
      cd06949
      Location:310547
      Blast Score: 1030
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180248
      Blast Score: 435
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Blast Score: 339
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:552595
      Blast Score: 172
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    3. NM_001122741.1NP_001116213.1  estrogen receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a different promoter, compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL078582, BC128573, BE084831, DB285906
      Consensus CDS
      CCDS5234.1
      UniProtKB/TrEMBL
      G4XH65
      UniProtKB/Swiss-Prot
      P03372
      Related
      ENSP00000342630, OTTHUMP00000017719, ENST00000338799, OTTHUMT00000043309
      Conserved Domains (4) summary
      cd06949
      Location:310547
      Blast Score: 1030
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180248
      Blast Score: 435
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Blast Score: 339
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:552595
      Blast Score: 172
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    4. NM_001122742.1NP_001116214.1  estrogen receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses a different promoter, compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL078582, BC128573, BE084831, DA329077
      Consensus CDS
      CCDS5234.1
      UniProtKB/TrEMBL
      G4XH65
      UniProtKB/Swiss-Prot
      P03372
      Related
      ENSP00000405330, ENST00000440973
      Conserved Domains (4) summary
      cd06949
      Location:310547
      Blast Score: 1030
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180248
      Blast Score: 435
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Blast Score: 339
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:552595
      Blast Score: 172
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      152011631..152424409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      149573851..149986188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF326912.1 AAG42501.1
    genomic AL035695.17 None
    genomic AL049821.6 CAI22123.1
      CAQ09842.1
      CAQ09843.1
    genomic AL049821.6 CAI22123.1
      CAQ09842.1
      CAQ09843.1
    genomic AL078582.13 CAI42285.1
    genomic AL356311.6 CAI21011.2
      CAI21012.1
    genomic AL590993.14 CAI14237.1
      CAQ10453.1
    genomic AL590993.14 CAI14237.1
      CAQ10453.1
    genomic AY425004.1 AAQ91815.1
    genomic CH471051.2 EAW47740.1
      EAW47741.1
    genomic CS405710.1 CAL40514.1
    genomic X62462.1 CAA44322.1
    mRNA AB307713.1 BAH02304.1
    mRNA AB588629.1 BAJ41265.1
    mRNA AB588630.1 BAJ41266.1
    mRNA AF120105.1 AAD23565.1
    mRNA AF258449.1 AAG41358.1
    mRNA AF258450.1 AAG41359.1
    mRNA AF258451.1 AAG41360.1
    mRNA AK293019.1 BAF85708.1
    mRNA AK304600.1 BAG65386.1
    mRNA AK304833.1 BAG65577.1
    mRNA AK309580.1 None
    mRNA AK311064.1 None
    mRNA AK313644.1 None
    mRNA AY750962.1 AAW69860.1
    mRNA BC128573.1 AAI28574.1
    mRNA BC128574.1 AAI28575.1
    mRNA BE084831.1 None
    mRNA BX640939.1 CAE45969.1
    mRNA DA329077.1 None
    mRNA DB285906.1 None
    mRNA EU921455.1 ACH41916.1
    mRNA EU982838.1 ACH73261.1
    mRNA EU982839.1 ACH73262.1
    mRNA EU982840.1 ACH73263.1
    mRNA FJ011556.1 ACI06210.1
    mRNA FJ011557.1 ACI06211.1
    mRNA FJ011558.1 ACI06212.1
    mRNA FJ011559.1 ACI06213.1
    mRNA FJ011560.1 ACI06214.1
    mRNA FJ147552.1 ACI01724.1
    mRNA FJ147553.1 ACI01725.1
    mRNA FJ147554.1 ACI01726.1
    mRNA FJ147555.1 ACI01727.1
    mRNA FJ147556.1 ACI01728.1
    mRNA FJ147557.1 ACI01729.1
    mRNA FJ147558.1 ACI01730.1
    mRNA FJ169500.1 ACI04255.1
    mRNA FJ169501.1 ACI04256.1
    mRNA FJ169502.1 ACI04257.1
    mRNA FJ169503.1 ACI04258.1
    mRNA FJ169504.1 ACI04259.1
    mRNA FJ668387.1 ACN41854.1
    mRNA FJ712305.1 ACN66633.1
    mRNA FJ712306.1 ACN66634.1
    mRNA FJ712307.1 ACN66635.1
    mRNA FJ716811.1 ACN89822.1
    mRNA FJ716812.1 ACN89823.1
    mRNA FJ716813.1 ACN89824.1
    mRNA FJ716814.1 ACN89825.1
    mRNA FJ716815.1 ACN89826.1
    mRNA GQ366704.1 ACU29456.1
    mRNA GQ411250.1 ACV41785.1
    mRNA GQ411251.1 ACV41786.1
    mRNA GQ411253.1 ACV41788.1
    mRNA GQ411258.1 ACV41793.1
    mRNA GQ438790.1 ACV88148.1
    mRNA GQ438791.1 ACV88149.1
    mRNA JF810888.1 AEP43755.1
    mRNA M12674.1 AAA52399.1
    mRNA M69297.1 AAA58462.1
    mRNA U47678.1 AAB00115.1
    mRNA U68067.1 AAC51874.1
    mRNA U68068.1 AAC51875.1
    mRNA X03635.1 CAA27284.1
      CAD97416.1
    mRNA X73067.1 CAA51528.1
    mRNA X74439.1 None
    mRNA Z75126.1 CAA99436.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4R1 GenPept UniProtKB/TrEMBL:A0A4R1
    P03372.2 GenPept UniProtKB/Swiss-Prot:P03372
    Q14267 GenPept UniProtKB/TrEMBL:Q14267
    Q14268 GenPept UniProtKB/TrEMBL:Q14268
    Q16405 GenPept UniProtKB/TrEMBL:Q16405
    Q5C8S5 GenPept UniProtKB/TrEMBL:Q5C8S5
    Q9H1Z6 GenPept UniProtKB/TrEMBL:Q9H1Z6
    Q9H2M1 GenPept UniProtKB/TrEMBL:Q9H2M1
    Q9H2M2 GenPept UniProtKB/TrEMBL:Q9H2M2
    Q9UBT1 GenPept UniProtKB/TrEMBL:Q9UBT1
    Q9UE35 GenPept UniProtKB/TrEMBL:Q9UE35
    Q9Y2W8 GenPept UniProtKB/TrEMBL:Q9Y2W8

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