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Frmd4a FERM domain containing 4A [ Mus musculus (house mouse) ]

Gene ID: 209630, updated on 8-May-2016
Official Symbol
Frmd4aprovided by MGI
Official Full Name
FERM domain containing 4Aprovided by MGI
Primary source
MGI:MGI:1919850
See related
Ensembl:ENSMUSG00000026657 Vega:OTTMUSG00000010755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Frmd4; Gm13190; AI594879; mKIAA1294; 5330420J21; 2700017I06Rik; C230040M21Rik; OTTMUSG00000010806
Orthologs
Location:
2; 2 A1
Exon count:
31
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (4017695..4614043)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (4073909..4535089)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 107, member B Neighboring gene predicted gene, 36031 Neighboring gene polypyrimidine tract-binding protein 1 pseudogene Neighboring gene RIKEN cDNA 1700080N15 gene Neighboring gene uncharacterized LOC102639987 Neighboring gene predicted gene, 39752 Neighboring gene predicted gene, 39751 Neighboring gene predicted gene 13179 Neighboring gene pre-mRNA processing factor 18 Neighboring gene predicted gene, 36334 Neighboring gene ribosomal protein L22 pseudogene

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding, bridging IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
establishment of epithelial cell polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
FERM domain-containing protein 4A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177843.1NP_001171314.1  FERM domain-containing protein 4A isoform 2

    See identical proteins and their annotated locations for NP_001171314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK082365, BC082808, BP768112
    Consensus CDS
    CCDS50488.1
    UniProtKB/Swiss-Prot
    Q8BIE6
    Related
    ENSMUSP00000075172, OTTMUSP00000011515, ENSMUST00000075767, OTTMUST00000025125
    Conserved Domains (5) summary
    pfam11819
    Location:340477
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:6206
    B41; Band 4.1 homologues
    pfam09379
    Location:988
    FERM_N; FERM N-terminal domain
    cd13191
    Location:202312
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:99198
    FERM_B-lobe; FERM domain B-lobe
  2. NM_001177844.1NP_001171315.1  FERM domain-containing protein 4A isoform 3

    See identical proteins and their annotated locations for NP_001171315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK171532, BC082808, BP768112, CJ101444
    Consensus CDS
    CCDS57151.1
    UniProtKB/TrEMBL
    Q3TB04
    Related
    ENSMUSP00000134803, OTTMUSP00000062023, ENSMUST00000176828, OTTMUST00000111004
    Conserved Domains (2) summary
    pfam11819
    Location:46183
    DUF3338; Domain of unknown function (DUF3338)
    cl17171
    Location:118
    PH-like; Pleckstrin homology-like domain
  3. NM_172475.3NP_766063.3  FERM domain-containing protein 4A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC058672, BC082808, BP768112, BY138785
    Consensus CDS
    CCDS15656.2
    UniProtKB/Swiss-Prot
    Q8BIE6
    Related
    ENSMUSP00000089079, OTTMUSP00000011590, ENSMUST00000091497, OTTMUST00000025131
    Conserved Domains (5) summary
    pfam11819
    Location:351488
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:17217
    B41; Band 4.1 homologues
    pfam09379
    Location:2099
    FERM_N; FERM N-terminal domain
    cd13191
    Location:213323
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:110209
    FERM_B-lobe; FERM domain B-lobe

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    4017695..4614043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497439.2XP_006497502.1  

    Related
    ENSMUSP00000134788, OTTMUSP00000062019, ENSMUST00000177457, OTTMUST00000110999
    Conserved Domains (5) summary
    pfam11819
    Location:355492
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:21221
    B41; Band 4.1 homologues
    pfam09379
    Location:24103
    FERM_N; FERM N-terminal domain
    cd13191
    Location:217327
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:114213
    FERM_B-lobe; FERM domain B-lobe
  2. XM_006497437.2XP_006497500.1  

    Conserved Domains (5) summary
    pfam11819
    Location:362499
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:28228
    B41; Band 4.1 homologues
    pfam09379
    Location:31110
    FERM_N; FERM N-terminal domain
    cd13191
    Location:224334
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:121220
    FERM_B-lobe; FERM domain B-lobe
  3. XM_006497443.2XP_006497506.1  

    Conserved Domains (5) summary
    pfam11819
    Location:370507
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:36236
    B41; Band 4.1 homologues
    pfam09379
    Location:39118
    FERM_N; FERM N-terminal domain
    cd13191
    Location:232342
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:129228
    FERM_B-lobe; FERM domain B-lobe
  4. XM_006497438.2XP_006497501.1  

    Conserved Domains (5) summary
    pfam11819
    Location:370507
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:36236
    B41; Band 4.1 homologues
    pfam09379
    Location:39118
    FERM_N; FERM N-terminal domain
    cd13191
    Location:232342
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:129228
    FERM_B-lobe; FERM domain B-lobe
  5. XM_006497436.2XP_006497499.1  

    Conserved Domains (5) summary
    pfam11819
    Location:370507
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:36236
    B41; Band 4.1 homologues
    pfam09379
    Location:39118
    FERM_N; FERM N-terminal domain
    cd13191
    Location:232342
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:129228
    FERM_B-lobe; FERM domain B-lobe
  6. XM_006497441.1XP_006497504.1  

    See identical proteins and their annotated locations for XP_006497504.1

    UniProtKB/Swiss-Prot
    Q8BIE6
    Conserved Domains (5) summary
    pfam11819
    Location:340477
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:6206
    B41; Band 4.1 homologues
    pfam09379
    Location:988
    FERM_N; FERM N-terminal domain
    cd13191
    Location:202312
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:99198
    FERM_B-lobe; FERM domain B-lobe
  7. XM_006497442.1XP_006497505.1  

    See identical proteins and their annotated locations for XP_006497505.1

    UniProtKB/Swiss-Prot
    Q8BIE6
    Conserved Domains (5) summary
    pfam11819
    Location:340477
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:6206
    B41; Band 4.1 homologues
    pfam09379
    Location:988
    FERM_N; FERM N-terminal domain
    cd13191
    Location:202312
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:99198
    FERM_B-lobe; FERM domain B-lobe
  8. XM_006497440.1XP_006497503.1  

    See identical proteins and their annotated locations for XP_006497503.1

    UniProtKB/Swiss-Prot
    Q8BIE6
    Conserved Domains (5) summary
    pfam11819
    Location:340477
    DUF3338; Domain of unknown function (DUF3338)
    smart00295
    Location:6206
    B41; Band 4.1 homologues
    pfam09379
    Location:988
    FERM_N; FERM N-terminal domain
    cd13191
    Location:202312
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd14473
    Location:99198
    FERM_B-lobe; FERM domain B-lobe

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    4101182..4566365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)