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Hace1 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 209462, updated on 8-May-2016
Official Symbol
Hace1provided by MGI
Official Full Name
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1provided by MGI
Primary source
MGI:MGI:2446110
See related
Ensembl:ENSMUSG00000038822 Vega:OTTMUSG00000025958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BC025474; 1700042J16Rik; A730034A22Rik
Orthologs
Location:
10; 10 B2
Exon count:
27
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (45577571..45712345)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (45297635..45432151)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene lin-28 homolog B (C. elegans) Neighboring gene predicted gene, 35372 Neighboring gene diazepam binding inhibitor-like 5, pseudogene Neighboring gene RIKEN cDNA D030045P18 gene Neighboring gene glutathione peroxidase 4, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • KIAA1320

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rab GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Rac GTPase binding ISO
Inferred from Sequence Orthology
more info
 
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Golgi organization ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
membrane fusion ISO
Inferred from Sequence Orthology
more info
 
protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
E3 ubiquitin-protein ligase HACE1
Names
HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172473.3NP_766061.2  E3 ubiquitin-protein ligase HACE1

    See identical proteins and their annotated locations for NP_766061.2

    Status: VALIDATED

    Source sequence(s)
    AC135669, AC153847, AK042879
    Consensus CDS
    CCDS23829.1
    UniProtKB/Swiss-Prot
    Q3U0D9
    Related
    ENSMUSP00000039206, OTTMUSP00000031750, ENSMUST00000037044, OTTMUST00000064027
    Conserved Domains (6) summary
    smart00119
    Location:579902
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:554903
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:92217
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:6695
    Ank; Ankyrin repeat
    pfam12796
    Location:69161
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199249
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    45577571..45712345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512637.2XP_006512700.1  

    Conserved Domains (5) summary
    smart00119
    Location:591870
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:566871
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:92207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:6695
    Ank; Ankyrin repeat
    pfam12796
    Location:69161
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_006512635.2XP_006512698.1  

    Conserved Domains (5) summary
    smart00119
    Location:561884
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:536885
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:62177
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:72164
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4688
    Ank_4; Ankyrin repeats (many copies)
  3. XM_006512634.2XP_006512697.1  

    Conserved Domains (5) summary
    smart00119
    Location:591914
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:566915
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:92207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:6695
    Ank; Ankyrin repeat
    pfam12796
    Location:69161
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_006512638.2XP_006512701.1  

    Conserved Domains (4) summary
    smart00119
    Location:399722
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:374723
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:66183
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:69161
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_006512636.2XP_006512699.1  

    Conserved Domains (5) summary
    smart00119
    Location:557880
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:532881
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:58173
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:3261
    Ank; Ankyrin repeat
    pfam12796
    Location:35127
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_011243149.1XP_011241451.1  

    Conserved Domains (4) summary
    smart00119
    Location:429752
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:404753
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:299
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:6103
    Ank_2; Ankyrin repeats (3 copies)
  7. XM_011243150.1XP_011241452.1  

    Conserved Domains (2) summary
    smart00119
    Location:318641
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:293642
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RNA

  1. XR_380058.2 RNA Sequence

  2. XR_380059.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    46446600..46579346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)