Taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Taf3provided by MGI
Official Full Name: TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factorprovided by MGI
Primary source: MGI:2388097
Locus tag: RP23-393G10.2
See related: Ensembl:ENSMUSG00000025782; Vega:OTTMUSG00000011183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 140kDa; TAF140; AW539625; TAFII140; TAFII-140; mTAFII140; 4933439M23Rik

Genomic context

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Location :: 2 A1; 2

Sequence :: Chromosome: 2; NC_000068.7 (9914552..10048609, complement)

See Taf3 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study shows that this TAF3 activity is critical for early lineage segregation during stem cell differentiation.
Title: Control of embryonic stem cell lineage commitment by core promoter factor, TAF3.
In vitro and cell-based assays identify a domain of TAF3 that mediates coactivator functions targeted by MyoD.
Title: MyoD targets TAF3/TRF3 to activate myogenin transcription.
Results report the solution structure of the TAF3-PHD finger and its complex with an H3K4me3 peptide.
Title: Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:229072	BioGRID:200340	Hmga1		BioGRID	PubMed	Affinity Capture-Western; Far Western; Protein-peptide; Reconstituted Complex
BioGRID:229072	BioGRID:200341	Hmga2		BioGRID	PubMed	Far Western; Reconstituted Complex

Pathways from BioSystems

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Basal transcription factors, organism-specific biosystem (from KEGG)
Basal transcription factors, organism-specific biosystem
Basal transcription factors
Basal transcription factors, conserved biosystem (from KEGG)
Basal transcription factors, conserved biosystem
Basal transcription factors
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...

General gene information

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Markers

Taf3 (e-PCR), detects polymorphism
- UniSTS:547377

NoName (e-PCR)
- UniSTS:234325

D2Mit233 (e-PCR), detects polymorphism
- UniSTS:129110

AW539625 (e-PCR)
- UniSTS:178567

Homology

Homologs of the Taf3 gene: The Taf3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and C.elegans.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
metal ion binding	IEA Inferred from Electronic Annotation more info
p53 binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
maintenance of protein location in nucleus	ISO Inferred from Sequence Orthology more info
negative regulation of sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
regulation of transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
transcription factor TFIID complex	ISA Inferred from Sequence Alignment more info	PubMed
transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 3

Names: transcription initiation factor TFIID subunit 3; TAF(II)140; TBP-associated factor 3; 140 kDa TATA box-binding protein-associated factor; RNA polymerase II transcription factor, TFIID subunit; transcription initiation factor TFIID 140 kDa subunit; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027748.3 → NP_082024.2 transcription initiation factor TFIID subunit 3

Status: VALIDATED

Source sequence(s)

AK136045, AW049595, BB621106, BC137618, CX763644

Consensus CDS

CCDS15675.1

UniProtKB/TrEMBL

A2ASY1

UniProtKB/Swiss-Prot

Q5HZG4

Related

ENSMUSP00000026888, OTTMUSP00000012021, ENSMUST00000026888, OTTMUST00000026272

Conserved Domains (2) summary

smart00576
Location:5 – 79
Blast Score: 292

BTP; Bromodomain transcription factors and PHD domain containing proteins

smart00249
Location:869 – 912
Blast Score: 150

PHD; PHD zinc finger

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38.p1 C57BL/6J

Range

9914552..10048609, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

9851959..9987814, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01013861.1	None
genomic	AAHY01013862.1	None
genomic	AAHY01013863.1	None
genomic	AAHY01013864.1	None
genomic	AAHY01013865.1	None
genomic	AAHY01013866.1	None
genomic	AAHY01013867.1	None
genomic	AAHY01013868.1	None
genomic	AAHY01013869.1	None
genomic	AAHY01013870.1	None
genomic	AAHY01013871.1	None
genomic	AL928704.10 (37649..171706)	None	ZRU
genomic	CH466542.1	EDL08000.1	mixed
mRNA	AJ292189.1	CAC34476.1
mRNA	AK017128.1	None	C57BL/6J
mRNA	AK030878.1	None	C57BL/6J
mRNA	AK033848.1	None	C57BL/6J
mRNA	AK051249.1	BAC34574.1	C57BL/6J
mRNA	AK084574.1	BAC39218.1	C57BL/6J
mRNA	AK136045.1	BAE22792.1	C57BL/6J
mRNA	AK154372.1	BAE32543.1	NOD
mRNA	AW049595.1	None	C57BL/6J
mRNA	BB621106.1	None	C57BL/6J
mRNA	BC039989.1	AAH39989.1	CZECHII
mRNA	BC053691.1	None	FVB/N
mRNA	BC089030.1	AAH89030.1	C57BL/6
mRNA	BC094546.1	AAH94546.1	C57BL/6
mRNA	BC137617.1	AAI37618.1
mRNA	BC137618.1	AAI37619.1
mRNA	CX763644.1	None