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Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 [ Mus musculus (house mouse) ]

Gene ID: 20928, updated on 8-May-2016
Official Symbol
Abcc9provided by MGI
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 9provided by MGI
Primary source
MGI:MGI:1352630
See related
Ensembl:ENSMUSG00000030249 Vega:OTTMUSG00000057137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sur2; SUR2A; SUR2B; AI414027; AI449286
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Orthologs
Location:
6 G2; 6 74.35 cM
Exon count:
44
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (142587862..142702760, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142536382..142650794, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38920 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 8 Neighboring gene RIKEN cDNA 5330439B14 gene Neighboring gene cytidine monophospho-N-acetylneuraminic acid synthetase Neighboring gene predicted gene, 31040 Neighboring gene sulfotransferase family 6B, member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IEA
Inferred from Electronic Annotation
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
sulfonylurea receptor activity ISO
Inferred from Sequence Orthology
more info
 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
defense response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
potassium ion import ISO
Inferred from Sequence Orthology
more info
 
potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ATP-sensitive potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
T-tubule ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ATP-binding cassette sub-family C member 9
Names
ATP-binding cassette transporter sub-family C member 9
sulfonylurea receptor 2
sulfonylurea-binding protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044720.1NP_001038185.1  ATP-binding cassette sub-family C member 9 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (d, also known as SUR2 delta17/39) has the same N- and C-termini but is shorter compared to isoform b. This RefSeq is based on data in PMID: 10224138.
    Source sequence(s)
    AC121611, BB612657, D86037
    UniProtKB/Swiss-Prot
    P70170
    UniProtKB/TrEMBL
    E9PUE8
    Related
    ENSMUSP00000107401, ENSMUST00000111771
    Conserved Domains (4) summary
    TIGR00957
    Location:231525
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:12941533
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669873
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9781250
    ABC_membrane; ABC transporter transmembrane region
  2. NM_001310143.1NP_001297072.1  ATP-binding cassette sub-family C member 9 isoform e

    See identical proteins and their annotated locations for NP_001297072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two exons in the 3' coding region, compared to variant 2. It encodes isoform e (also known as SUR2 delta17/40), which lacks an internal in-frame segment and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC121611
    Conserved Domains (4) summary
    TIGR00957
    Location:231530
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:12941533
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669873
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9781250
    ABC_membrane; ABC transporter transmembrane region
  3. NM_011511.2NP_035641.1  ATP-binding cassette sub-family C member 9 isoform a

    See identical proteins and their annotated locations for NP_035641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding region compared to variant 2. The resulting isoform (a, also known as SUR2B or SUR2-40) has a distinct C-terminus compared to isoform b.
    Source sequence(s)
    AC121611, BB612657, D86038
    Consensus CDS
    CCDS39696.1
    UniProtKB/Swiss-Prot
    P70170
    Related
    ENSMUSP00000098390, OTTMUSP00000073641, ENSMUST00000100827, OTTMUST00000140695
    Conserved Domains (4) summary
    TIGR00957
    Location:231543
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:13071546
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669886
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9911263
    ABC_membrane; ABC transporter transmembrane region
  4. NM_021041.2NP_066378.1  ATP-binding cassette sub-family C member 9 isoform b

    See identical proteins and their annotated locations for NP_066378.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes isoform b (also known as SUR2A or SUR2-39).
    Source sequence(s)
    AC121611, BB612657, D86037
    Consensus CDS
    CCDS39699.1
    UniProtKB/Swiss-Prot
    P70170
    Related
    ENSMUSP00000084805, OTTMUSP00000073642, ENSMUST00000087527, OTTMUST00000140696
    Conserved Domains (4) summary
    TIGR00957
    Location:231538
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:13071546
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669886
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9911263
    ABC_membrane; ABC transporter transmembrane region
  5. NM_021042.2NP_066379.2  ATP-binding cassette sub-family C member 9 isoform c

    See identical proteins and their annotated locations for NP_066379.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (c, also known as SUR2 delta14/39) has the same N- and C-termini but is shorter compared to isoform b.
    Source sequence(s)
    AC121611, BB612657, D86037
    Consensus CDS
    CCDS39697.1
    UniProtKB/Swiss-Prot
    P70170
    Related
    ENSMUSP00000072914, ENSMUST00000073173
    Conserved Domains (4) summary
    TIGR00957
    Location:231503
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:12721511
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:635851
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9561228
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    142587862..142702760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506949.2XP_006507012.1  

    See identical proteins and their annotated locations for XP_006507012.1

    UniProtKB/Swiss-Prot
    P70170
    Conserved Domains (4) summary
    TIGR00957
    Location:231543
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:13071546
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669886
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9911263
    ABC_membrane; ABC transporter transmembrane region
  2. XM_006506950.2XP_006507013.1  

    See identical proteins and their annotated locations for XP_006507013.1

    UniProtKB/Swiss-Prot
    P70170
    Conserved Domains (4) summary
    TIGR00957
    Location:231543
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:13071546
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669886
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9911263
    ABC_membrane; ABC transporter transmembrane region
  3. XM_006506948.2XP_006507011.1  

    See identical proteins and their annotated locations for XP_006507011.1

    UniProtKB/Swiss-Prot
    P70170
    Conserved Domains (4) summary
    TIGR00957
    Location:231543
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:13071546
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669886
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9911263
    ABC_membrane; ABC transporter transmembrane region
  4. XM_006506952.2XP_006507015.1  

    Conserved Domains (4) summary
    cd03288
    Location:12981537
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:660877
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9821254
    ABC_membrane; ABC transporter transmembrane region
    TIGR01271
    Location:2121524
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
  5. XM_006506953.2XP_006507016.1  

    See identical proteins and their annotated locations for XP_006507016.1

    Conserved Domains (4) summary
    TIGR00957
    Location:231530
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:12941533
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669873
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9781250
    ABC_membrane; ABC transporter transmembrane region
  6. XM_006506951.2XP_006507014.1  

    See identical proteins and their annotated locations for XP_006507014.1

    UniProtKB/Swiss-Prot
    P70170
    Conserved Domains (4) summary
    TIGR00957
    Location:231543
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:13071546
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669886
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9911263
    ABC_membrane; ABC transporter transmembrane region

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    145649701..145764495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021043.1: Suppressed sequence

    Description
    NM_021043.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.