Supt5h suppressor of Ty 5 homolog (S. cerevisiae) [Mus musculus] - Gene

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Summary

Official Symbol: Supt5hprovided by MGI
Official Full Name: suppressor of Ty 5 homolog (S. cerevisiae)provided by MGI
Primary source: MGI:1202400
See related: Ensembl:ENSMUSG00000003435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spt5; AL033283; AL033321; AU019549

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Genomic context

Location :: 7 A3; 7 10.0 cM

Sequence :: Chromosome: 7; NC_000073.6 (28314894..28338719, complement)

See Supt5h in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study reports that Spt5, a factor normally associated with stalled or paused Pol II, is required for class switch recombination.
Title: Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:203575	BioGRID:119716	C9orf78	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:107995	DBN1	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:109230	GTF3C1	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:109766	IK	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:121617	KIAA1377	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:119211	MED31	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:115139	PHYHIP	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:121232	PNO1	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:111474	PPIA	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:206582	Ppp2r2d	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:112052	RPL8	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:118881	SAP30BP	BioGRID	PubMed	Two-hybrid
BioGRID:203575	BioGRID:203573	Supt4h1	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
enzyme binding	ISO Inferred from Sequence Orthology more info
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
negative regulation of transcription elongation, DNA-dependent	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription elongation from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription elongation, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
regulation of transcription elongation, DNA-dependent	IEA Inferred from Electronic Annotation more info
regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transcription elongation from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
transcription elongation, DNA-dependent	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: transcription elongation factor SPT5

Names: transcription elongation factor SPT5; DSIF large subunit; DRB sensitivity-inducing factor large subunit

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013676.1 → NP_038704.1 transcription elongation factor SPT5

Status: PROVISIONAL

Source sequence(s)

BC007132

Consensus CDS

CCDS39857.1

UniProtKB/Swiss-Prot

O55201

Related

ENSMUSP00000003527, ENSMUST00000003527

Conserved Domains (7) summary

COG5164
Location:332 – 869
Blast Score: 556

SPT5; Transcription elongation factor [Transcription]

PRK08559
Location:173 – 314
Blast Score: 155

nusG; transcription antitermination protein NusG; Validated

pfam11029
Location:910 – 954
Blast Score: 89

DAZAP2; DAZ associated protein 2 (DAZAP2)

cd09888
Location:176 – 263
Blast Score: 388

NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)

cl00354
Location:469 – 496
Blast Score: 97

KOW; KOW motif

pfam11942
Location:95 – 170
Blast Score: 131

Spt5_N; Spt5 transcription elongation factor, acidic N-terminal

cl15277
Location:766 – 879
Blast Score: 199

Nucleoporin_FG; Nucleoporin FG repeat region

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38 C57BL/6J

Range

28314894..28338719, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

22876535..22900354, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC002327.1 (102231..126066)	None
genomic	AC148986.5 (208198..232023)	None
genomic	CH466593.2	EDL24145.1	mixed
mRNA	AK047062.1	None	C57BL/6J
mRNA	AK145117.1	BAE26244.1
mRNA	AK145465.1	None	C57BL/6J
mRNA	AK146055.1	BAE26864.1	C57BL/6J
mRNA	AK146453.1	BAE27184.1	C57BL/6J
mRNA	AK146583.1	BAE27278.1	C57BL/6J
mRNA	AK146650.1	BAE27330.1	C57BL/6J
mRNA	AK159786.1	None	C57BL/6J
mRNA	AK178008.1	None
mRNA	AK179916.1	None
mRNA	AK182624.1	None
mRNA	AK184267.1	None
mRNA	AK184514.1	None
mRNA	AK186836.1	None
mRNA	AK187681.1	None
mRNA	AK192346.1	None
mRNA	AK194137.1	None
mRNA	AK194240.1	None
mRNA	AK196241.1	None
mRNA	AK197516.1	None
mRNA	AK205376.1	None
mRNA	AK213469.1	None
mRNA	AK214897.1	None
mRNA	BC007132.1	AAH07132.1
mRNA	BC057449.1	AAH57449.1	FVB/N
mRNA	BC058598.1	AAH58598.1
mRNA	BC059849.1	AAH59849.1	C57BL/6
mRNA	U88539.1	AAC40052.1