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    FBL fibrillarin [ Homo sapiens ]

    Gene ID: 2091, updated on 11-May-2012

    Summary

    Official Symbol
    FBLprovided by HGNC
    Official Full Name
    fibrillarinprovided by HGNC
    Primary source
    HGNC:3599
    See related
    Ensembl:ENSG00000105202; HPRD:00617; MIM:134795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIB; FLRN; RNU3IP1
    Summary
    This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    19q13.1
    Sequence :
    Chromosome: 19; NC_000019.9 (40325093..40337054, complement)

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene leucine twenty homeobox Neighboring gene dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B Neighboring gene Fc fragment of IgG binding protein Neighboring gene proline rich 13 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001427.2 SNORD3A    BIND  PubMed Fibrillarin interacts with U3 snoRNA 
    P22087 Q92841 DDX17    HPRD  PubMed  
    P22087 P17844 DDX5    HPRD  PubMed  
    P22087 Q99558 MAP3K14    HPRD  PubMed  
    P22087 Q9Y237 PIN4    HPRD  PubMed  
    P22087 Q99873 PRMT1    HPRD  PubMed  
    P22087 P28072 PSMB6    HPRD  PubMed  
    P22087 Q16637 SMN2    HPRD  PubMed  
    P22087 Survival of motor neuron 2, centromeric SMN2    HPRD  PubMed  
    P22087 P63162 SNRPN    HPRD  PubMed  
    P22087 Q9HA65 TBC1D17    HPRD  PubMed  
    BioGRID:108399 BioGRID:106902 ARRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:107054 BAK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:107169 C1QBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:107396 CD40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:107487 CENPA    BioGRID  PubMed Co-purification 
    BioGRID:108399 BioGRID:116387 DDX20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108399 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108399 BioGRID:120075 DDX56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:114059 GEMIN2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108399 BioGRID:119102 GEMIN4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108399 BioGRID:109272 H3F3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:107711 KLF6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108399 BioGRID:115710 MCRS1    BioGRID  PubMed Co-fractionation 
    BioGRID:108399 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:110902 NOP2    BioGRID  PubMed Co-fractionation 
    BioGRID:108399 BioGRID:115783 NOP56    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108399 BioGRID:203509 Nhp2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:116790 PASK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:120343 PIH1D1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108399 BioGRID:111320 PIN4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108399 BioGRID:109512 PRMT1    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:108399 BioGRID:115491 PRMT3    BioGRID  PubMed Biochemical Activity 
    BioGRID:108399 BioGRID:115688 PRMT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:120469 PRMT6    BioGRID  PubMed Biochemical Activity 
    BioGRID:108399 BioGRID:114309 RIOK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:114187 RTCA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:114166 RUVBL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108399 BioGRID:116067 RUVBL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108399 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:108399 BioGRID:112743 TAF9    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108399 BioGRID:122849 TBC1D17    BioGRID  PubMed Two-hybrid 
    BioGRID:108399 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:113129 TUBA3C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:123347 TUBB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108399 BioGRID:204613 Ybx1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108399 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    • Homologs of the FBL gene: The FBL gene is conserved in chimpanzee, , dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    snoRNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    box C/D snoRNP complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    granular component IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rRNA 2'-O-methyltransferase fibrillarin
    Names
    rRNA 2'-O-methyltransferase fibrillarin
    34-kD nucleolar scleroderma antigen
    34 kDa nucleolar scleroderma antigen
    RNA, U3 small nucleolar interacting protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001436.3NP_001427.2  rRNA 2'-O-methyltransferase fibrillarin

      Status: REVIEWED

      Source sequence(s)
      AI085380, BC019260, BG831506
      Consensus CDS
      CCDS12545.1
      UniProtKB/Swiss-Prot
      P22087
      Related
      ENSP00000221801, ENST00000221801
      Conserved Domains (2) summary
      COG1889
      Location:86314
      Blast Score: 820
      NOP1; Fibrillarin-like rRNA methylase [Translation, ribosomal structure and biogenesis]
      cl16911
      Location:82320
      Blast Score: 1195
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      40325093..40337054, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      36772106..36784069, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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