Cpeb3 cytoplasmic polyadenylation element binding protein 3 [Mus musculus] - Gene

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Summary

Official Symbol: Cpeb3provided by MGI
Official Full Name: cytoplasmic polyadenylation element binding protein 3provided by MGI
Primary source: MGI:2443075
See related: Ensembl:ENSMUSG00000039652; Vega:OTTMUSG00000033003
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0940; 4831444O18Rik; KIAA0940

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Genomic context

Location :: 19 C2; 19

Sequence :: Chromosome: 19; NC_000085.6 (37021291..37207293, complement)

See Cpeb3 in Epigenomics, MapViewer

Chromosome 19 - NC_000085.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest a model whereby Neuralized1-dependent ubiquitination facilitates hippocampal plasticity and hippocampal-dependent memory storage by modulating the activity of CPEB3 and CPEB3-dependent protein synthesis and synapse formation.
Title: Neuralized1 activates CPEB3: a function for nonproteolytic ubiquitin in synaptic plasticity and memory storage.
CPEB3 has a novel function in the nucleus as to suppress Stat5b-dependent EGFR gene transcription
Title: A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.
show that CPEB3 expression is increased in a time-dependent manner during the course of postnatal development, and CPEB3 is localized mostly in the inner retina, including retinal ganglion cells.
Title: Characterization of the transcripts and protein isoforms for cytoplasmic polyadenylation element binding protein-3 (CPEB3) in the mouse retina.
CPEB3 is a sequence-specific translational regulatory protein.
Title: CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.
CPEB3 is expressed in the principal cell layers of the hippocampus
Title: Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:229024	BioGRID:201732	Neurl1a		BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:229024	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
RNA binding	IEA Inferred from Electronic Annotation more info
molecular_function	ND No biological Data available more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info

General protein information

Preferred Names: cytoplasmic polyadenylation element-binding protein 3

Names: cytoplasmic polyadenylation element-binding protein 3; CPE-BP3; mCPEB-3; CPE-binding protein 3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198300.2 → NP_938042.2 cytoplasmic polyadenylation element-binding protein 3

Status: PROVISIONAL

Source sequence(s)

AB093274, AC118931, AK147243, BB642665

Consensus CDS

CCDS29775.1

UniProtKB/Swiss-Prot

Q7TN99

Related

ENSMUSP00000118723, OTTMUSP00000044109, ENSMUST00000132580, OTTMUST00000082320

Conserved Domains (2) summary

cd00590
Location:460 – 547
Blast Score: 148

RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

cl02586
Location:568 – 628
Blast Score: 100

RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000085.6 Reference GRCm38 C57BL/6J

Range

37021291..37207293, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000041.1 Alternate Mm_Celera

Range

37797394..37982920, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC113124.9 (101404..216546)	None
genomic	AC118931.8 (165551..233366)	None
genomic	AC161238.7 (138866..141909)	None
genomic	CH466534.1	EDL41778.1	mixed
mRNA	AB093274.1	BAC41458.1
mRNA	AK029261.1	None	C57BL/6J
mRNA	AK033860.1	None	C57BL/6J
mRNA	AK044639.1	None	C57BL/6J
mRNA	AK147243.1	BAE27791.1	C57BL/6J
mRNA	AK161513.1	BAE36436.1	C57BL/6J
mRNA	AK163089.1	None	C57BL/6J
mRNA	AY313774.1	AAQ20843.1	BALB/c
mRNA	BB642665.1	None	C57BL/6J
mRNA	BC128377.1	AAI28378.1