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Wnt8a wingless-type MMTV integration site family, member 8A [ Mus musculus (house mouse) ]

Gene ID: 20890, updated on 28-May-2016
Official Symbol
Wnt8aprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 8Aprovided by MGI
Primary source
MGI:MGI:107924
See related
Ensembl:ENSMUSG00000012282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt8d; Stra11; Wnt-8A; Wnt-8D
Orthologs
Location:
18; 18 B3
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (34542058..34548960)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (34701982..34707715)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene polycystic kidney disease 2-like 2 Neighboring gene SET translocation pseudogene Neighboring gene family with sequence similarity 13, member B Neighboring gene RIKEN cDNA 4933408B17 gene Neighboring gene NME/NM23 family member 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystem (from REACTOME)
    Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • WNT ligand biogenesis and trafficking, organism-specific biosystem (from REACTOME)
    WNT ligand biogenesis and trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Wnt signaling, organism-specific biosystem (from KEGG)
    Wnt signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling, conserved biosystem (from KEGG)
    Wnt signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of organ orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
palate development ISO
Inferred from Sequence Orthology
more info
 
polarity specification of anterior/posterior axis IMP
Inferred from Mutant Phenotype
more info
PubMed 
polarity specification of proximal/distal axis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regionalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein Wnt-8a
Names
protein Wnt-8d
stimulated by retinoic acid gene 11 protein
wingless-related MMTV integration site 8A
wingless-related MMTV integration site 8D
wnt-8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009290.2NP_033316.1  protein Wnt-8a precursor

    See identical proteins and their annotated locations for NP_033316.1

    Status: VALIDATED

    Source sequence(s)
    AC074335, BC120517, Z68889
    Consensus CDS
    CCDS29129.1
    UniProtKB/Swiss-Prot
    Q64527
    UniProtKB/TrEMBL
    Q0VBT1
    Related
    ENSMUSP00000012426, ENSMUST00000012426
    Conserved Domains (1) summary
    pfam00110
    Location:39336
    wnt; wnt family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    34542058..34548960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525738.2XP_006525801.1  

    See identical proteins and their annotated locations for XP_006525801.1

    UniProtKB/Swiss-Prot
    Q64527
    Conserved Domains (1) summary
    pfam00110
    Location:39336
    wnt; wnt family
  2. XM_011246866.1XP_011245168.1  

    Conserved Domains (1) summary
    pfam00110
    Location:22280
    wnt; wnt family

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    34995948..35001675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)