Aurka aurora kinase A [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Aurkaprovided by MGI
Official Full Name: aurora kinase Aprovided by MGI
Primary source: MGI:894678
See related: Ensembl:ENSMUSG00000027496; Vega:OTTMUSG00000016161
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; AU019385; AW539821; Aurora-A

Genomic context

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Location :: 2 H3; 2 94.84 cM

Sequence :: Chromosome: 2; NC_000068.7 (172356196..172370506, complement)

See Aurka in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The deletion of Aurora kinase Ain the developing epidermis altered centrosome function of basal keratinocytes and markedly impaired their ability to divide and stratify.
Title: Aurora kinase-A deficiency during skin development impairs cell division and stratification.
Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes.
Title: Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo.
Aurora kinase A regulates pluripotency through phosphorylation-mediated inhibition of p53-directed ectodermal and mesodermal gene expression
Title: Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.
Epiblast ablation of Aurora A allows establishment of the anteroposterior axis but leads to failure to progress through gastrulation.
Title: Conditional Aurora A deficiency differentially affects early mouse embryo patterning.
Results suggest a posttranslational regulatory network in which the Pten and Fbxw7 pathways appear to converge on the regulation of Aurora-A level.
Title: Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
This study demonistrated that cross talk between Aurora-A and CDK5 during neuronal migration.
Title: Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization.
FBXL7 specifically interacts with Aurora A during mitosis but not in interphase, suggesting a regulatory role for FBXL7 in controlling Aurora A abundance during mitosis.
Title: Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest.
AurkA plays critical roles in mouse oocyte meiosis by regulating spindle and chromosome dynamics
Title: Aurora kinase-A regulates microtubule organizing center (MTOC) localization, chromosome dynamics, and histone-H3 phosphorylation in mouse oocytes.
Cdk1 activity is required for mitotic activation of aurora A during G2/M transition
Title: Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells.
Wild-type-Aurora-A enhances focus formation and aggregation of the RasV12 transformants in mouse NIH3T3 fibroblast derived cell lines over-expressing RasV12
Title: Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway.

Submit: New GeneRIF Correction See all (30)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:203548	BioGRID:198550	Ccnd3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203548	BioGRID:231141	Chfr	BioGRID	PubMed	Reconstituted Complex
BioGRID:203548	BioGRID:200196	H3f3a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203548	BioGRID:211070	Sirt2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203548	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Oocyte meiosis, organism-specific biosystem (from KEGG)
Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Oocyte meiosis, conserved biosystem (from KEGG)
Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

RH136493 (e-PCR)
- UniSTS:210476

AW539821 (e-PCR)
- UniSTS:178783

Aurka (e-PCR), detects polymorphism
- UniSTS:530824

Aurka (e-PCR), detects polymorphism
- UniSTS:530825

Aurka (e-PCR), detects polymorphism
- UniSTS:527267

U69106 (e-PCR)
- UniSTS:163305

Homology

Homologs of the Aurka gene: The Aurka gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
cell projection organization	IEA Inferred from Electronic Annotation more info
mitosis	IEA Inferred from Electronic Annotation more info
mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
centrosome	ISO Inferred from Sequence Orthology more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
microtubule	IEA Inferred from Electronic Annotation more info
nucleus	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
spindle	ISO Inferred from Sequence Orthology more info
spindle microtubule	ISO Inferred from Sequence Orthology more info
spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aurora kinase A

Names: aurora kinase A; ARK-1; aurora 2; aurora A; aurora family kinase 1; aurora-related kinase 1; serine/threonine kinase 6; aurora/IPL1-related kinase 1; ipl1- and aurora-related kinase 1; serine/threonine-protein kinase 6; serine/threonine-protein kinase Ayk1; serine/threonine-protein kinase aurora-A

NP_035627.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011497.3 → NP_035627.1 aurora kinase A

Status: PROVISIONAL

Source sequence(s)

AL833787, AL844162

Consensus CDS

CCDS17129.1

UniProtKB/Swiss-Prot

P97477

Related

ENSMUSP00000028997, ENSMUST00000028997

Conserved Domains (2) summary

cd05123
Location:152 – 395
Blast Score: 694

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:146 – 396
Blast Score: 795

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38.p1 C57BL/6J

Range

172356196..172370506, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

178315373..178329688, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01013065.1 (10513..24828)	None
genomic	AL833787.8 (2000..13534)	None
genomic	AL844162.9 (77413..80190)	None
genomic	CH466551.1	EDL06600.1	mixed
		EDL06601.1	mixed
mRNA	AF007817.1	AAB63205.1	BALB/c
mRNA	AK077513.1	BAC36838.1	C57BL/6J
mRNA	AK085861.1	BAC39557.1	C57BL/6J
mRNA	AK145968.1	BAE26793.1	C57BL/6J
mRNA	AK169363.1	BAE41112.1	C57BL/6J
mRNA	AK189850.1	None
mRNA	AY336976.1	AAQ16152.1	C57BL/6J
mRNA	BC005425.1	AAH05425.1	CZECHII
mRNA	BC014711.1	AAH14711.1	FVB/N
mRNA	U69106.1	AAC12682.1	BALB/c
mRNA	U80932.1	AAB62982.1