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Aurka aurora kinase A [ Mus musculus (house mouse) ]

Gene ID: 20878, updated on 15-May-2016
Official Symbol
Aurkaprovided by MGI
Official Full Name
aurora kinase Aprovided by MGI
Primary source
MGI:MGI:894678
See related
Ensembl:ENSMUSG00000027496 Vega:OTTMUSG00000016161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; AU019385; AW539821; Aurora-A
Orthologs
Location:
2 H3; 2 94.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (172356190..172370706, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (172181696..172196006, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene 14273 Neighboring gene family with sequence similarity 210, member B Neighboring gene cleavage stimulation factor, 3' pre-RNA, subunit 1 Neighboring gene Cas scaffolding protein family member 4 Neighboring gene replication termination factor 2 domain containing 1 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone serine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome organization IGI
Inferred from Genetic Interaction
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic centrosome separation IGI
Inferred from Genetic Interaction
more info
PubMed 
mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of spindle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection extension IGI
Inferred from Genetic Interaction
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
spindle assembly involved in female meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon hillock IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome ISO
Inferred from Sequence Orthology
more info
 
chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
condensed nuclear chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
germinal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center IGI
Inferred from Genetic Interaction
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle ISO
Inferred from Sequence Orthology
more info
 
spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 
spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
aurora kinase A
Names
aurora 2
aurora A
aurora family kinase 1
aurora-related kinase 1
aurora/IPL1-related kinase 1
ipl1- and aurora-related kinase 1
serine/threonine kinase 6
serine/threonine-protein kinase 6
serine/threonine-protein kinase Ayk1
serine/threonine-protein kinase aurora-A
NP_001278114.1
NP_035627.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291185.1NP_001278114.1  aurora kinase A isoform b

    See identical proteins and their annotated locations for NP_001278114.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK145968, AL833787, AL844162
    Consensus CDS
    CCDS71204.1
    UniProtKB/Swiss-Prot
    P97477
    UniProtKB/TrEMBL
    Q3TEY6
    Related
    ENSMUSP00000104768, OTTMUSP00000017293, ENSMUST00000109140, OTTMUST00000038659
    Conserved Domains (2) summary
    smart00220
    Location:124374
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:118374
    PKc_like; Protein Kinases, catalytic domain
  2. NM_011497.4NP_035627.1  aurora kinase A isoform a

    See identical proteins and their annotated locations for NP_035627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK145968, AL833787, AL844162, CD560646
    Consensus CDS
    CCDS17129.1
    UniProtKB/Swiss-Prot
    P97477
    UniProtKB/TrEMBL
    Q3TEY6
    Related
    ENSMUSP00000028997, ENSMUST00000028997
    Conserved Domains (2) summary
    smart00220
    Location:146396
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14116
    Location:140396
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    172356190..172370706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499075.2XP_006499138.1  

    See identical proteins and their annotated locations for XP_006499138.1

    UniProtKB/Swiss-Prot
    P97477
    UniProtKB/TrEMBL
    Q3TEY6
    Conserved Domains (2) summary
    smart00220
    Location:124374
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:118374
    PKc_like; Protein Kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    178315367..178329752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)