Aurka aurora kinase A [Mus musculus] - Gene

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Summary

Official Symbol: Aurkaprovided by MGI
Official Full Name: aurora kinase Aprovided by MGI
Primary source: MGI:894678
See related: Ensembl:ENSMUSG00000027496; Vega:OTTMUSG00000016161
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; AU019385; AW539821; Aurora-A

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Genomic context

Location :: 2 H3; 2 100.0 cM

Sequence :: Chromosome: 2; NC_000068.7 (172356196..172370506, complement)

See Aurka in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AurkA plays critical roles in mouse oocyte meiosis by regulating spindle and chromosome dynamics
Title: Aurora kinase-A regulates microtubule organizing center (MTOC) localization, chromosome dynamics, and histone-H3 phosphorylation in mouse oocytes.
Cdk1 activity is required for mitotic activation of aurora A during G2/M transition
Title: Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells.
Wild-type-Aurora-A enhances focus formation and aggregation of the RasV12 transformants in mouse NIH3T3 fibroblast derived cell lines over-expressing RasV12
Title: Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway.
These findings demonstrate a surprising role of aPKC-Aurora A-NDEL1 pathway in microtubule remodelling during neurite extension.
Title: An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.
Data show that the transgenic mouse model provides a useful system that allows the study of the physiologic effects of Aurora-A on liver regeneration and the genetic pathways of Aurora-A-mediated tumorigenesis in liver.
Title: Aurora-A overexpression in mouse liver causes p53-dependent premitotic arrest during liver regeneration.
Conditional Aurora-A ablation in cultured embryonic fibroblasts causes impaired mitotic entry and mitotic arrest with a profound defect in bipolar spindle formation.
Title: Aurora-A kinase is essential for bipolar spindle formation and early development.
analysis of the negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1
Title: Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1.
balanced Aurora A level is critical for maintaining genomic stability
Title: Aurora A is essential for early embryonic development and tumor suppression.
E2F3 modulates Aurora-A mRNA expression during the cell cycle.
Title: Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle progression.
AURKA is a critical MTOC-associated component involved in resumption of meiosis, MTOC multiplication, proper spindle formation and the metaphase I-metaphase II transition.
Title: Aurora kinase A controls meiosis I progression in mouse oocytes.

Submit: New GeneRIF Correction See all (23)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation
Gene trapped (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:203548	BioGRID:231141	Chfr	BioGRID	PubMed	Reconstituted Complex
BioGRID:203548	BioGRID:200196	H3f3a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203548	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
cell projection organization	IEA Inferred from Electronic Annotation more info
mitosis	IEA Inferred from Electronic Annotation more info
mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
centrosome	ISO Inferred from Sequence Orthology more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
microtubule	IEA Inferred from Electronic Annotation more info
nucleus	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
spindle	ISO Inferred from Sequence Orthology more info
spindle microtubule	ISO Inferred from Sequence Orthology more info
spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: aurora kinase A

Names: aurora kinase A; ARK-1; aurora 2; aurora A; aurora family kinase 1; aurora-related kinase 1; serine/threonine kinase 6; aurora/IPL1-related kinase 1; ipl1- and aurora-related kinase 1; serine/threonine-protein kinase 6; serine/threonine-protein kinase Ayk1; serine/threonine-protein kinase aurora-A

NP_035627.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011497.3 → NP_035627.1 aurora kinase A

Status: PROVISIONAL

Source sequence(s)

AL833787, AL844162

Consensus CDS

CCDS17129.1

UniProtKB/Swiss-Prot

P97477

Related

ENSMUSP00000028997, ENSMUST00000028997

Conserved Domains (2) summary

cd05123
Location:152 – 395
Blast Score: 694

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:146 – 396
Blast Score: 795

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38 C57BL/6J

Range

172356196..172370506, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

178315373..178329688, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL833787.8 (2000..13533)	None
genomic	AL844162.9 (77412..80189)	None
genomic	CH466551.1	EDL06600.1	mixed
		EDL06601.1	mixed
mRNA	AF007817.1	AAB63205.1	BALB/c
mRNA	AK077513.1	BAC36838.1	C57BL/6J
mRNA	AK085861.1	BAC39557.1	C57BL/6J
mRNA	AK145968.1	BAE26793.1	C57BL/6J
mRNA	AK169363.1	BAE41112.1	C57BL/6J
mRNA	AK189850.1	None
mRNA	AY336976.1	AAQ16152.1	C57BL/6J
mRNA	BC005425.1	AAH05425.1	CZECHII
mRNA	BC014711.1	AAH14711.1	FVB/N
mRNA	U69106.1	AAC12682.1	BALB/c
mRNA	U80932.1	AAB62982.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P97477.1	GenPept	UniProtKB/Swiss-Prot:P97477
Q3TEY6	GenPept	UniProtKB/TrEMBL:Q3TEY6
Q7TNK2	GenPept	UniProtKB/TrEMBL:Q7TNK2
Q8BP87	GenPept	UniProtKB/TrEMBL:Q8BP87