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Aurkb aurora kinase B [ Mus musculus (house mouse) ]

Gene ID: 20877, updated on 8-May-2016
Official Symbol
Aurkbprovided by MGI
Official Full Name
aurora kinase Bprovided by MGI
Primary source
MGI:MGI:107168
See related
Ensembl:ENSMUSG00000020897 Vega:OTTMUSG00000005961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aik2; Aim1; Ark2; AurB; IPL1; Stk5; AIM-1; AIRK2; STK-1; Stk12; AL022959
Summary
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 2 and 7. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. [provided by RefSeq, Sep 2015]
Orthologs
Location:
11 B3; 11 42.32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (69045625..69051664)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68859145..68865164)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glycine 6 (anticodon TCC) Neighboring gene nuclear encoded tRNA trytophan 7 (anticodon CCA) Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene nuclear encoded tRNA isoleucine 4 (anticodon AAT)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone serine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
cleavage furrow formation ISO
Inferred from Sequence Orthology
more info
 
histone H3-S28 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle midzone assembly ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
spindle checkpoint IEA
Inferred from Electronic Annotation
more info
 
spindle organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromocenter IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome passenger complex IDA
Inferred from Direct Assay
more info
PubMed 
chromosome passenger complex ISO
Inferred from Sequence Orthology
more info
 
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
condensed chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
condensed nuclear chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
 
condensed nuclear chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
kinetochore ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
midbody ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spindle ISO
Inferred from Sequence Orthology
more info
 
spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 
spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
aurora kinase B
Names
ARK-2
aurora 1
aurora B
aurora- and IPL1-like midbody-associated protein 1
aurora-related kinase 2
aurora/IPL1-related kinase 2
serine/threonine kinase 12
serine/threonine kinase 5
serine/threonine-protein kinase 12
serine/threonine-protein kinase 5
serine/threonine-protein kinase aurora-B
NP_035626.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011496.2NP_035626.1  aurora kinase B

    See identical proteins and their annotated locations for NP_035626.1

    Status: REVIEWED

    Source sequence(s)
    AK075951, BY005259, CO040997
    Consensus CDS
    CCDS24877.1
    UniProtKB/Swiss-Prot
    O70126
    Related
    ENSMUSP00000021277, OTTMUSP00000006162, ENSMUST00000021277, OTTMUST00000013306
    Conserved Domains (2) summary
    smart00220
    Location:82332
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:77344
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    69045625..69051664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532725.2XP_006532788.1  

    Conserved Domains (2) summary
    smart00220
    Location:13207
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:13219
    PKc_like; Protein Kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    75989163..75995182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)