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    Eif4g1 eukaryotic translation initiation factor 4, gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 208643, updated on 11-May-2013
    Official Symbol
    Eif4g1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4, gamma 1provided by MGI
    Primary source
    MGI:2384784
    See related
    Ensembl:ENSMUSG00000045983; Vega:OTTMUSG00000024386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    eIF4GI; E030015G23Rik
    Location :
    16 B1; 16
    Sequence :
    Chromosome: 16; NC_000082.6 (20672749..20692883)
    See Eif4g1 in Epigenomics, MapViewer

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131, member A Neighboring gene chloride channel 2 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide H

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362.
    2. MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle. Hu SI, et al. Sci Signal, 2012 Feb 14. PMID 22337810.
    3. Expression of truncated eukaryotic initiation factor 3e (eIF3e) resulting from integration of mouse mammary tumor virus (MMTV) causes a shift from cap-dependent to cap-independent translation. Chiluiza D, et al. J Biol Chem, 2011 Sep 9. PMID 21737453.
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    5. NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome. Alard A, et al. Mol Cell Biol, 2010 Feb. PMID 20028737.

    See all (32) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data indicate that MNK2 plays a unique role, not shared by its closest paralog MNK1, in limiting protein translation through its negative effect on eIF4G Ser1108 phosphorylation and p70S6K activation.
      Title: MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.
    2. expression of 3e5 diminishes eIF4G interaction with eIF3 and causes abnormal gene expression at the translational level.
      Title: Expression of truncated eukaryotic initiation factor 3e (eIF3e) resulting from integration of mouse mammary tumor virus (MMTV) causes a shift from cap-dependent to cap-independent translation.
    3. findings assign NAD(P)H quinone-oxydoreductase 1 an original role in the regulation of mRNA translation via the control of eIF4GI stability by the proteasome.
      Title: NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome.
    4. downregulated expression in T cells following treatment with bis(tri-n-butylin)oxide (TBTO), an immunotoxic organotin compound
      Title: Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO).
    5. Poly(A) binding protein (PABP) is identified as an Msi1-binding protein, and Msi1 competes with eIF4G for PABP binding.
      Title: Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.
    6. These findings suggest that the ability of cells to rephosphorylate 4E-BP1, resynthesise eIF4GI and restore the rate of protein synthesis after inactivation of p53 is an important aspect of recovery following the relief of physiological stress.
      Title: Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53.
    7. Comparison of the p53-induced patterns of eIF4GI and 4E-BP1 dephosphorylation and cleavage with those caused by the mammalian target of rapamycin inhibitor rapamycin
      Title: Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53.
    8. eIF4G binding to Mnk is inhibted by Mnk1 phosphorylation by caspase-activated Pak2/gamma-PAK
      Title: Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
    9. interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G
      Title: Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
    10. analysis of cells of eIF4GIf molecules lacking either the PABP-binding site, the eIF3-binding site, the middle domain eIF4A-binding site, or the C-terminal segment that includes the second eIF4A-binding site
      Title: Functional analysis of individual binding activities of the scaffold protein eIF4G.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description
    NP_031943.2 Eif4e    BIND  PubMed eIF4E interacts with an unspecified isoform of eIF4GI. 
    BioGRID:228998 BioGRID:203183 Foxp3    BioGRID  PubMed Affinity Capture-MS 
    NP_067436.1 Mknk1    BIND  PubMed Mknk1 (Mnk1) interacts with Eif4g1. This interaction was modelled on a demonstrated interaction between mouse Mnk1 and Eif4g1 from an unspecified species or an unspecified isoform of human Eif4g1. 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC37551, MGC90776

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    eukaryotic translation initiation factor 4F complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    eukaryotic translation initiation factor 4 gamma 1
    Names
    eukaryotic translation initiation factor 4 gamma 1
    eIF-4G1
    eIF-4G 1
    eIF-4-gamma 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005331.1 → NP_001005331.1  eukaryotic translation initiation factor 4 gamma 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AK081982, BC066038, BC066103
      Consensus CDS
      CCDS28054.1
      UniProtKB/TrEMBL
      E9Q9E1
      UniProtKB/Swiss-Prot
      Q6NZJ6
      UniProtKB/TrEMBL
      Q8BUW8
      Related
      ENSMUSP00000073506, ENSMUST00000073840
      Conserved Domains (4) summary
      smart00544
      Location:1235 – 1347
      Blast Score: 324
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins.
      pfam02854
      Location:758 – 986
      Blast Score: 466
      MIF4G; MIF4G domain
      cd11559
      Location:1446 – 1563
      Blast Score: 348
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      cl17013
      Location:1541 – 1590
      Blast Score: 108
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    2. NM_145941.2 → NP_666053.2  eukaryotic translation initiation factor 4 gamma 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AK081982, BC066038, BC066103
      Consensus CDS
      CCDS28055.1
      UniProtKB/Swiss-Prot
      Q6NZJ6
      UniProtKB/TrEMBL
      Q8BUW8
      Related
      ENSMUSP00000047678, OTTMUSP00000029085, ENSMUST00000044783, OTTMUST00000059747
      Conserved Domains (4) summary
      smart00544
      Location:1242 – 1354
      Blast Score: 324
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins.
      pfam02854
      Location:765 – 993
      Blast Score: 467
      MIF4G; MIF4G domain
      cd11559
      Location:1453 – 1570
      Blast Score: 348
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      cl17013
      Location:1548 – 1597
      Blast Score: 108
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p1 C57BL/6J

      Range
      20672749..20692883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000038.1 Alternate Mm_Celera

      Range
      21237424..21258239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01126209.1 (2834..3572) None
    genomic AAHY01126210.1 None
    genomic AC087898.19 (12232..32366) None C57BL/6J
    genomic CH466521.1 EDK97586.1 mixed
    mRNA AJ746222.1 CAG34102.1
    mRNA AK053144.1 BAC35282.1 C57BL/6J
    mRNA AK081982.1 BAC38386.1 C57BL/6J
    mRNA AK133903.1 BAE21918.1 C57BL/6J
    mRNA AK134557.1 BAE22186.1 C57BL/6J
    mRNA AK139371.1 BAE23980.1 C57BL/6J
    mRNA AK142399.1 BAE25056.1 C57BL/6J
    mRNA AK150050.1 None C57BL/6J
    mRNA AK162698.1 None C57BL/6J
    mRNA AK193078.1 None
    mRNA BC021441.1 AAH21441.1 CZECHII
    mRNA BC027166.1 AAH27166.1 FVB/N
    mRNA BC031177.1 AAH31177.1 FVB/N
    mRNA BC058950.1 AAH58950.1 C57BL/6
    mRNA BC066038.1 AAH66038.1 C57BL/6
    mRNA BC066103.1 AAH66103.1 C57BL/6
    mRNA BC079675.1 AAH79675.1 C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZJ6.1 GenPept UniProtKB/Swiss-Prot:Q6NZJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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        Order cDNA clone
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      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
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        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
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      • HomoloGene
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      • Nucleotide
        Link to related Nucleotide entry
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        Related Probe entry
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        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
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        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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