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ERH enhancer of rudimentary homolog (Drosophila) [ Homo sapiens (human) ]

Gene ID: 2079, updated on 26-May-2016
Official Symbol
ERHprovided by HGNC
Official Full Name
enhancer of rudimentary homolog (Drosophila)provided by HGNC
Primary source
HGNC:HGNC:3447
See related
Ensembl:ENSG00000100632 HPRD:09026; MIM:601191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DROER
Orthologs
Location:
14q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (69380123..69398304, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (69846840..69865021, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370550 Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 16 Neighboring gene uncharacterized LOC105370549 Neighboring gene solute carrier family 39 member 9 Neighboring gene uncharacterized LOC105370551

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of enhancer of rudimentary homolog (Drosophila, ERH) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, enhancer of rudimentary homolog (ERH), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ERH is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ27340

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
pyrimidine nucleoside metabolic process TAS
Traceable Author Statement
more info
PubMed 
pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane IEA
Inferred from Electronic Annotation
more info
 
methylosome IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
enhancer of rudimentary homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004450.2NP_004441.1  enhancer of rudimentary homolog

    See identical proteins and their annotated locations for NP_004441.1

    Status: VALIDATED

    Source sequence(s)
    AK130850, U66871
    Consensus CDS
    CCDS9794.1
    UniProtKB/Swiss-Prot
    P84090
    UniProtKB/TrEMBL
    A0A024R6D4
    Related
    ENSP00000451080, OTTHUMP00000245828, ENST00000557016, OTTHUMT00000412990
    Conserved Domains (1) summary
    pfam01133
    Location:1103
    ER; Enhancer of rudimentary

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    69380123..69398304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    69784977..69803158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)