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    ERH enhancer of rudimentary homolog (Drosophila) [ Homo sapiens ]

    Gene ID: 2079, updated on 11-May-2012
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    Summary

    Official Symbol
    ERHprovided by HGNC
    Official Full Name
    enhancer of rudimentary homolog (Drosophila)provided by HGNC
    Primary source
    HGNC:3447
    See related
    Ensembl:ENSG00000100632; HPRD:09026; MIM:601191; Vega:OTTHUMG00000171323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DROER; FLJ27340
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    Genomic context

    Location :
    14q24.1; 7q34
    Sequence :
    Chromosome: 14; NC_000014.8 (69846840..69865021, complement)
    See ERH in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 Neighboring gene solute carrier family 39 (zinc transporter), member 9 Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. Giannone RJ, et al. PLoS One, 2010 Aug 25. PMID 20811636.

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Enhancer of rudimentary homolog (ERH) overexpression may be implicated in the initiation and/or progression of certain human malignancies.
      Title: Enhancer of the rudimentary gene homologue (ERH) expression pattern in sporadic human breast cancer and normal breast tissue.
    2. interaction with ERH could block the binding of p21(Cip1/Waf1) by Ciz1 in the cell. When ERH and Ciz1 are coexpressed in HeLa cells, Ciz1 recruits ERH to DNA replication foci
      Title: Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog.
    3. ERH may be an important transcription regulator that also functions in the control of cell-cycle progression.
      Title: A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks.
    4. molecular structure, dimerization and protein-protein interactions
      Title: Structure of the conserved transcriptional repressor enhancer of rudimentary homolog.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004441.1 NP_004706.2 CTDP1    BIND  PubMed FCP1 interacts with ERH. 
    P84090 Q7L5N1 COPS6    HPRD  PubMed  
    P84090 P68400 CSNK2A1    HPRD  PubMed  
    P84090 P19784 CSNK2A2    HPRD  PubMed  
    P84090 Q9Y5B0 CTDP1    HPRD  PubMed  
    P84090 P11142 HSPA8    HPRD  PubMed  
    P84090 Q96ID5 IGSF21    HPRD  PubMed  
    P84090 Q9Y3C7 MED31    HPRD  PubMed  
    P84090 Hypothetical protein DKFZp564O0523 RBM48    HPRD  PubMed  
    P84090 Q15047 SETDB1    HPRD  PubMed  
    P84090 Q99962 SH3GL2    HPRD  PubMed  
    P84090 Q04724 TLE1    HPRD  PubMed  
    P84090 P04637 TP53    HPRD  PubMed  
    P84090 Q13432 UNC119    HPRD  PubMed  
    BioGRID:108390 BioGRID:119378 ACP6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:120995 BIN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:113387 CNBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:116176 COPS6    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:114597 CTDP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108390 BioGRID:115578 EIF1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:199505 Erh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:109544 HSPA8    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:124396 IGSF21    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:109824 ILK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:119211 MED31    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:123855 RBM48    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:114676 RPS6KA5    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:112353 SH3GL2    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:112943 TLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:113010 TP53    BioGRID  PubMed Two-hybrid 
    BioGRID:108390 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108390 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleobase-containing compound metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    pyrimidine nucleoside metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    enhancer of rudimentary homolog
    Names
    enhancer of rudimentary homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004450.2 → NP_004441.1  enhancer of rudimentary homolog

      Status: VALIDATED

      Source sequence(s)
      AK130850, U66871
      Consensus CDS
      CCDS9794.1
      UniProtKB/Swiss-Prot
      P84090
      Related
      ENSP00000451080, OTTHUMP00000245828, ENST00000557016, OTTHUMT00000412990
      Conserved Domains (1) summary
      pfam01133
      Location:1 – 103
      Blast Score: 500
      ER; Enhancer of rudimentary

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      69846840..69865021, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      50015612..50033561, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL157996.8 (120363..138539) None
    genomic CH471061.1 EAW80989.1
      EAW80990.1
    mRNA AK130850.1 None
    mRNA AK312186.1 BAG35119.1
    mRNA BC014301.2 AAH14301.1
    mRNA BC071709.1 AAH71709.1
    mRNA BT006877.1 AAP35523.1
    mRNA CR450298.1 CAG29294.1
    mRNA CR542178.1 CAG46975.1
    mRNA D85758.1 BAA12865.1
    mRNA U66871.1 AAC51172.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84090.1 GenPept UniProtKB/Swiss-Prot:P84090
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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    Tools
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      Supplemental Content

      Table of contents

      Links

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