Srebf1 sterol regulatory element binding transcription factor 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Srebf1provided by MGI
Official Full Name: sterol regulatory element binding transcription factor 1provided by MGI
Primary source: MGI:107606
Locus tag: RP23-456O18.1
See related: Ensembl:ENSMUSG00000020538; Vega:OTTMUSG00000005809
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADD1; ADD-1; SREBP1; bHLHd1; SREBP-1; SREBP1c; SREBP-1a; SREBP-1c; D630008H06

Genomic context

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Location :: 11 B2; 11

Sequence :: Chromosome: 11; NC_000077.6 (60199089..60220604, complement)

See Srebf1 in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alpinia officinarum ethanol extract dose-dependently suppressed lipid accumulation during differentiation of 3T3-L1 preadipocytes by downregulating C/EBPalpha, SREBP-1 and PPAR-gamma genes.
Title: Alpinia officinarum inhibits adipocyte differentiation and high-fat diet-induced obesity in mice through regulation of adipogenesis and lipogenesis.
The regulation of SREBP-1c gene expression by SIRT1 may require the deacetylation of LXR transcription factors.
Title: Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle.
SREBP-1a specifically activates the Api6 gene through a binding site in its proximal promoter, thus establishing the Api6 gene as a newly identified SREBP-1a target gene
Title: Protection from bacterial-toxin-induced apoptosis in macrophages requires the lipogenic transcription factor sterol regulatory element binding protein 1a.
The mRNA and protein expression of SREBP-1 was significantly increased, indicating that the Fbxw7-SREBP-1 axis may play a key pathological role in the development of NAFLD.
Title: Evaluation of Fbxw7 expression and its correlation with expression of SREBP-1 in a mouse model of NAFLD.
Fed LiRiKO mice displayed loss of Akt Ser473 phosphorylation and reduced glucokinase and SREBP1c activity in the liver.
Title: Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
FoxO1 inhibits SREBP-1c transcription via combined actions on multiple transcription factors and that this effect is exerted at least in part through reduced transcriptional activity of Sp1 and SREBP-1c
Title: FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c.
Data reveal that aberrant activation of LXR reproduced the phenomenon of beta cell dysfunction in the development of type 2 diabetes. Upregulation of SREBP1c production and the lipotoxicity mediated by it played a central role in this process.
Title: Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines.
phosphorylation of SREBP-1a by ERK, JNK and p38 MAPK-families resembles a biological principle and plays a significant role in vivo
Title: Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity.
Kr-pok increases transcriptional activation of the FASN gene by interacting with SREBP-1c.
Title: Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter.
Treatment with an EGCG-free water-soluble fraction of geeen tea reduced expression Srebf1 and/or Srebf2 in the liver, which contributed to the down-regulation of the lipogenic enzymes by effect of epigallocatechin gallate.
Title: Effects of a catechin-free fraction derived from green tea on gene expression of enzymes related to lipid metabolism in the mouse liver.

Submit: New GeneRIF Correction See all (122)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation
Targeted (Reporter) (1) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_035610.1	NP_573512.1	Ppargc1b	BIND	PubMed	SREBP1c interacts with PGC-1-beta.
BioGRID:203495	BioGRID:199551	Ewsr1	BioGRID	PubMed	Two-hybrid
BioGRID:203495	BioGRID:199068	Pcbd1	BioGRID	PubMed	Two-hybrid
BioGRID:203495	BioGRID:228460	Ppargc1b	BioGRID	PubMed	Two-hybrid
BioGRID:203495	BioGRID:202853	Rela	BioGRID	PubMed	Two-hybrid
BioGRID:203495	BioGRID:228889	Zbtb7c	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Pathways from BioSystems

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Activation of Gene Expression by SREBP (SREBF), organism-specific biosystem (from REACTOME)
Activation of Gene Expression by SREBP (SREBF), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
Circadian Clock, organism-specific biosystem (from REACTOME)
Circadian Clock, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
Insulin signaling pathway, organism-specific biosystem (from KEGG)
Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
Insulin signaling pathway, conserved biosystem (from KEGG)
Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
PPARA Activates Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RORA Activates Circadian Expression, organism-specific biosystem (from REACTOME)
RORA Activates Circadian Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Cholesterol Biosynthesis by SREBP (SREBF), organism-specific biosystem (from REACTOME)
Regulation of Cholesterol Biosynthesis by SREBP (SREBF), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

Srebf1 (e-PCR), detects polymorphism
- UniSTS:507243

PMC134715P1 (e-PCR)
- UniSTS:270743

PMC164762P1 (e-PCR)
- UniSTS:271514

PMC166346P1 (e-PCR)
- UniSTS:271583

GDB:592807 (e-PCR)
- UniSTS:157923

RH132247 (e-PCR)
- UniSTS:215530

Homology

Homologs of the Srebf1 gene: The Srebf1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	ISO Inferred from Sequence Orthology more info
protein dimerization activity	IEA Inferred from Electronic Annotation more info
protein kinase binding	IPI Inferred from Physical Interaction more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
sterol response element binding	ISO Inferred from Sequence Orthology more info
sterol response element binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
cellular response to starvation	ISO Inferred from Sequence Orthology more info
cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
lipid biosynthetic process	IDA Inferred from Direct Assay more info
lipid metabolic process	IEA Inferred from Electronic Annotation more info
negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of cholesterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of fatty acid biosynthetic process	TAS Traceable Author Statement more info	PubMed
positive regulation of histone deacetylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of heart rate by chemical signal	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info	PubMed
response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
steroid metabolic process	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic part	IDA Inferred from Direct Assay more info
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
membrane	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
protein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sterol regulatory element-binding protein 1

Names: sterol regulatory element-binding protein 1; adipocyte determination- and differentiation-dependent factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011480.3 → NP_035610.1 sterol regulatory element-binding protein 1 precursor

Status: PROVISIONAL

Source sequence(s)

AL669954

Consensus CDS

CCDS24785.1

UniProtKB/Swiss-Prot

Q9WTN3

Related

ENSMUSP00000020846, OTTMUSP00000005985, ENSMUST00000020846, OTTMUST00000012870

Conserved Domains (1) summary

cd00083
Location:315 – 372
Blast Score: 172

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38.p1 C57BL/6J

Range

60199089..60220604, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

66655030..66676425

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01093725.1 (22595..28586)	None
genomic	AAHY01093726.1	None
genomic	AL669954.6 (37876..59392)	None
genomic	CH466678.1	EDL26614.1	mixed
		EDL26615.1	mixed
		EDL26616.1	mixed
mRNA	AB017337.1	BAA74795.1
mRNA	AF374266.1	AAK54762.1
mRNA	AK040663.1	None	C57BL/6J
mRNA	AK052628.1	BAC35068.1	C57BL/6J
mRNA	AK150052.1	BAE29268.1	C57BL/6J
mRNA	AK154424.1	BAE32576.1	NOD
mRNA	AK158269.1	BAE34440.1	C57BL/6J
mRNA	AK169607.1	BAE41256.1	NOD
mRNA	AK198337.1	None
mRNA	AK205046.1	None
mRNA	AK209898.1	None
mRNA	AK216773.1	None
mRNA	BC006051.1	AAH06051.1	CZECHII
mRNA	BC056922.1	AAH56922.1	C57BL/6