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Spock1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 [ Mus musculus (house mouse) ]

Gene ID: 20745, updated on 8-May-2016
Official Symbol
Spock1provided by MGI
Official Full Name
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1provided by MGI
Primary source
MGI:MGI:105371
See related
Ensembl:ENSMUSG00000056222 Vega:OTTMUSG00000049775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spock; Ticn1; testican
Orthologs
Location:
13; 13 B2
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (57421195..57908332, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (57522556..58009693, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105245516 Neighboring gene predicted gene, 33197 Neighboring gene predicted gene, 33294 Neighboring gene predicted gene, 33240 Neighboring gene predicted gene, 40963 Neighboring gene kelch-like 3 Neighboring gene microRNA 874 Neighboring gene predicted gene, 33389

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
metalloendopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
node of Ranvier IDA
Inferred from Direct Assay
more info
PubMed 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
sarcoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
testican-1
Names
testican 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166463.1NP_001159935.1  testican-1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001159935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame small exon in the 5' coding region, as compared to variant 1. The resulting isoform (3) is 3 aa shorter than isoform 1.
    Source sequence(s)
    AC154748, AK051191, BY232939
    Consensus CDS
    CCDS49279.1
    UniProtKB/TrEMBL
    Q8BKQ3
    Related
    ENSMUSP00000140755, OTTMUSP00000068548, ENSMUST00000186271, OTTMUST00000126787
    Conserved Domains (3) summary
    cd00104
    Location:139178
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00191
    Location:312373
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:197315
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
  2. NM_001166464.1NP_001159936.1  testican-1 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 3' sequence, as compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK036189, AK039058
    Consensus CDS
    CCDS79194.1
    UniProtKB/TrEMBL
    A0A087WPP6, Q8BM07, Q8BM19
    Related
    ENSMUSP00000139863, OTTMUSP00000068541, ENSMUST00000189373, OTTMUST00000126778
    Conserved Domains (2) summary
    cd00104
    Location:142181
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00252
    Location:200318
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
  3. NM_001166465.1NP_001159937.1  testican-1 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001159937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame small exon in the 5' coding region, and has an alternate 3' sequence, as compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK036189, AK039058, BY232939
    Consensus CDS
    CCDS79193.1
    UniProtKB/TrEMBL
    Q8BM07, Q8BM19
    Related
    ENSMUSP00000141130, OTTMUSP00000068540, ENSMUST00000187852, OTTMUST00000126777
    Conserved Domains (2) summary
    cd00104
    Location:139178
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00252
    Location:197315
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
  4. NM_001166466.1NP_001159938.1  testican-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001159938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site, as compared to variant 1. The reading frame is not changed and the resulting isoform (2) lacks an internal aa, as compared to isoform 1.
    Source sequence(s)
    AC154748, BB628964, BC158020
    UniProtKB/TrEMBL
    B2RXY1
    Conserved Domains (3) summary
    cd00104
    Location:142181
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00191
    Location:314375
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:200317
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
  5. NM_009262.3NP_033288.2  testican-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033288.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154748, BC075625, BY241184
    Consensus CDS
    CCDS79195.1
    UniProtKB/TrEMBL
    Q6DIC9
    Related
    ENSMUSP00000140409, OTTMUSP00000068542, ENSMUST00000185502, OTTMUST00000126779
    Conserved Domains (3) summary
    cd00104
    Location:142181
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00191
    Location:315376
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:200318
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    57421195..57908332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    58485985..58970735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)