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Pkn2 protein kinase N2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 207122, updated on 8-May-2016
Official Symbol
Pkn2provided by RGD
Official Full Name
protein kinase N2provided by RGD
Primary source
RGD:620146
See related
Ensembl:ENSRNOG00000011317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Pak-2; Prkcl2
Summary
phospholipid-regulated protein kinase, phosphorylates ribosomal protein S6; may play a role in hepatic regulation [RGD, Feb 2006]
Orthologs
Location:
2q44
Exon count:
22
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (248735699..248840735, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (267265825..267370861, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene kynurenine aminotransferase 3 Neighboring gene general transcription factor IIB Neighboring gene uncharacterized LOC102546591 Neighboring gene uncharacterized LOC102546938

  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • RHO GTPases activate PKNs, organism-specific biosystem (from REACTOME)
    RHO GTPases activate PKNs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
poly(A) RNA binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
apical junction assembly IEA
Inferred from Electronic Annotation
more info
 
apical junction assembly ISO
Inferred from Sequence Orthology
more info
 
apical junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 
epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell motility IEA
Inferred from Electronic Annotation
more info
 
regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical junction complex IEA
Inferred from Electronic Annotation
more info
 
apical junction complex ISO
Inferred from Sequence Orthology
more info
 
apical junction complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
cleavage furrow ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
intracellular IBA
Inferred from Biological aspect of Ancestor
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
midbody ISO
Inferred from Sequence Orthology
more info
 
midbody ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine/threonine-protein kinase N2
Names
PKN gamma
cardiolipin-activated protein kinase Pak2
p140 kinase
protease-activated kinase 2
protein kinase C-like 2
protein-kinase C-related kinase 2
NP_001099225.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105755.2NP_001099225.2  serine/threonine-protein kinase N2

    Status: VALIDATED

    Source sequence(s)
    AABR07013668, AABR07013669, AABR07013670
    UniProtKB/TrEMBL
    F1LPA4
    Related
    ENSRNOP00000034133, ENSRNOT00000031748
    Conserved Domains (6) summary
    cd08687
    Location:389472
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:42107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11631
    Location:128201
    HR1_PKN2_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd11635
    Location:209282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    smart00220
    Location:661915
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:656981
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    248735699..248840735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761494.1XP_008759716.1  

    Conserved Domains (6) summary
    cd11622
    Location:42107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11631
    Location:128201
    HR1_PKN2_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd11635
    Location:209282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    smart00220
    Location:613867
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:608933
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:389471
    C2; C2 domain

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    223803766..223906746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)